Incidental Mutation 'IGL02677:Vipr1'
ID 303210
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vipr1
Ensembl Gene ENSMUSG00000032528
Gene Name vasoactive intestinal peptide receptor 1
Synonyms VIP-R1, VPAC1, VIP receptor subtype 1
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL02677
Quality Score
Status
Chromosome 9
Chromosomal Location 121471782-121502020 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 121489349 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000035115 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035115]
AlphaFold P97751
Predicted Effect probably benign
Transcript: ENSMUST00000035115
SMART Domains Protein: ENSMUSP00000035115
Gene: ENSMUSG00000032528

DomainStartEndE-ValueType
signal peptide 1 30 N/A INTRINSIC
HormR 59 131 7.38e-26 SMART
Pfam:7tm_2 140 386 1.4e-95 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129394
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139189
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213272
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit prenatal lethality associated with severe neonatal growth failure, enlarged cecum, intestinal hemorrhage, and enterocyte hyperproliferation in addition to disorganized islets and impaired glucose homeostasisin surviving mice. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931406B18Rik G T 7: 43,150,519 (GRCm39) Y84* probably null Het
Adam5 A G 8: 25,302,395 (GRCm39) probably benign Het
Aipl1 T C 11: 71,920,222 (GRCm39) E282G possibly damaging Het
Akp3 A G 1: 87,052,994 (GRCm39) D61G probably damaging Het
Anpep A G 7: 79,488,478 (GRCm39) S451P probably damaging Het
Csnka2ip A G 16: 64,298,675 (GRCm39) L119P probably damaging Het
Ddx19a T C 8: 111,716,241 (GRCm39) E53G probably benign Het
Ddx50 C T 10: 62,452,072 (GRCm39) R116Q unknown Het
Ddx60 A T 8: 62,441,166 (GRCm39) E1078D probably damaging Het
Dpy19l1 T C 9: 24,396,368 (GRCm39) D116G probably damaging Het
Dsg4 A G 18: 20,597,933 (GRCm39) T668A possibly damaging Het
Dspp A G 5: 104,323,843 (GRCm39) T329A possibly damaging Het
Eftud2 T C 11: 102,737,440 (GRCm39) T554A probably damaging Het
Enpp1 T C 10: 24,555,083 (GRCm39) probably benign Het
Ext2 A T 2: 93,537,590 (GRCm39) F599I probably damaging Het
Fahd1 A T 17: 25,068,504 (GRCm39) I191N probably damaging Het
Fcrl2 A T 3: 87,166,694 (GRCm39) S100T probably benign Het
Fras1 T A 5: 96,692,883 (GRCm39) C181S probably damaging Het
Garre1 T A 7: 33,941,834 (GRCm39) probably benign Het
Gcnt4 A G 13: 97,083,741 (GRCm39) I346V probably benign Het
Gfra1 G A 19: 58,441,787 (GRCm39) T48I probably damaging Het
Kcnma1 A G 14: 23,513,224 (GRCm39) Y392H probably damaging Het
Klc2 T C 19: 5,161,696 (GRCm39) Y298C probably damaging Het
Lamb3 G A 1: 193,021,830 (GRCm39) V1011I probably benign Het
Ldb1 T C 19: 46,024,594 (GRCm39) probably benign Het
Mcph1 A G 8: 18,675,609 (GRCm39) K11E probably damaging Het
Myc A G 15: 61,861,513 (GRCm39) H374R probably damaging Het
Myom1 A G 17: 71,391,344 (GRCm39) Y853C probably damaging Het
Or4k38 A T 2: 111,166,147 (GRCm39) I92N probably damaging Het
Pakap C T 4: 57,856,263 (GRCm39) P572S probably benign Het
Pclo A G 5: 14,726,943 (GRCm39) probably benign Het
Pde3a G A 6: 141,350,898 (GRCm39) probably benign Het
Per1 T C 11: 68,997,486 (GRCm39) V887A probably benign Het
Prokr1 G A 6: 87,565,350 (GRCm39) probably benign Het
Rb1cc1 A G 1: 6,319,643 (GRCm39) I1021V probably benign Het
Ryr1 T C 7: 28,810,033 (GRCm39) E344G probably benign Het
Sec24c A T 14: 20,739,710 (GRCm39) D529V probably damaging Het
Slc1a6 T C 10: 78,624,898 (GRCm39) V101A probably damaging Het
Srrm1 G A 4: 135,052,415 (GRCm39) P658L unknown Het
Tap2 G A 17: 34,431,021 (GRCm39) V374M probably benign Het
Tex15 T A 8: 34,061,108 (GRCm39) D179E probably benign Het
Tmem8b T C 4: 43,686,092 (GRCm39) L241P probably damaging Het
Tmprss11g T C 5: 86,640,149 (GRCm39) D160G probably benign Het
Trim30a C T 7: 104,085,120 (GRCm39) C30Y probably damaging Het
Ttn A G 2: 76,601,840 (GRCm39) probably benign Het
Ush2a A G 1: 188,466,882 (GRCm39) R2849G probably damaging Het
Usp5 A G 6: 124,796,389 (GRCm39) V570A probably damaging Het
Zc2hc1c A C 12: 85,336,850 (GRCm39) D169A probably benign Het
Other mutations in Vipr1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01456:Vipr1 APN 9 121,494,244 (GRCm39) missense probably damaging 0.99
IGL01779:Vipr1 APN 9 121,493,696 (GRCm39) missense probably damaging 1.00
IGL01809:Vipr1 APN 9 121,490,506 (GRCm39) missense possibly damaging 0.70
IGL02250:Vipr1 APN 9 121,494,255 (GRCm39) missense probably benign 0.10
bernalillo UTSW 9 121,493,684 (GRCm39) missense probably damaging 1.00
R0036:Vipr1 UTSW 9 121,490,049 (GRCm39) missense probably benign
R0514:Vipr1 UTSW 9 121,487,115 (GRCm39) missense probably damaging 1.00
R0629:Vipr1 UTSW 9 121,489,237 (GRCm39) nonsense probably null
R1470:Vipr1 UTSW 9 121,494,586 (GRCm39) missense possibly damaging 0.66
R1470:Vipr1 UTSW 9 121,494,586 (GRCm39) missense possibly damaging 0.66
R1766:Vipr1 UTSW 9 121,490,485 (GRCm39) missense possibly damaging 0.87
R1884:Vipr1 UTSW 9 121,494,930 (GRCm39) missense possibly damaging 0.56
R1945:Vipr1 UTSW 9 121,497,541 (GRCm39) missense probably damaging 1.00
R1945:Vipr1 UTSW 9 121,497,540 (GRCm39) missense probably damaging 1.00
R2366:Vipr1 UTSW 9 121,494,250 (GRCm39) missense probably benign 0.19
R4275:Vipr1 UTSW 9 121,493,684 (GRCm39) missense probably damaging 1.00
R4600:Vipr1 UTSW 9 121,494,202 (GRCm39) splice site probably null
R5012:Vipr1 UTSW 9 121,487,111 (GRCm39) critical splice acceptor site probably null
R6190:Vipr1 UTSW 9 121,493,719 (GRCm39) missense probably damaging 1.00
R6376:Vipr1 UTSW 9 121,493,640 (GRCm39) missense probably damaging 1.00
R6473:Vipr1 UTSW 9 121,497,621 (GRCm39) missense probably damaging 1.00
R6476:Vipr1 UTSW 9 121,498,489 (GRCm39) missense probably benign 0.28
R6641:Vipr1 UTSW 9 121,498,631 (GRCm39) makesense probably null
R6752:Vipr1 UTSW 9 121,482,959 (GRCm39) missense probably damaging 0.99
R7189:Vipr1 UTSW 9 121,493,620 (GRCm39) missense probably damaging 0.97
R7371:Vipr1 UTSW 9 121,497,621 (GRCm39) missense probably damaging 1.00
R7419:Vipr1 UTSW 9 121,490,539 (GRCm39) missense probably damaging 0.97
R7647:Vipr1 UTSW 9 121,482,905 (GRCm39) missense possibly damaging 0.79
R8123:Vipr1 UTSW 9 121,498,518 (GRCm39) missense probably damaging 1.00
R8225:Vipr1 UTSW 9 121,471,915 (GRCm39) start codon destroyed possibly damaging 0.59
R8675:Vipr1 UTSW 9 121,493,732 (GRCm39) missense probably damaging 1.00
R9256:Vipr1 UTSW 9 121,490,118 (GRCm39) missense probably benign 0.09
R9343:Vipr1 UTSW 9 121,471,993 (GRCm39) critical splice donor site probably null
R9344:Vipr1 UTSW 9 121,471,993 (GRCm39) critical splice donor site probably null
R9422:Vipr1 UTSW 9 121,471,993 (GRCm39) critical splice donor site probably null
R9424:Vipr1 UTSW 9 121,471,993 (GRCm39) critical splice donor site probably null
R9463:Vipr1 UTSW 9 121,471,993 (GRCm39) critical splice donor site probably null
R9464:Vipr1 UTSW 9 121,471,993 (GRCm39) critical splice donor site probably null
R9517:Vipr1 UTSW 9 121,471,993 (GRCm39) critical splice donor site probably null
R9576:Vipr1 UTSW 9 121,471,993 (GRCm39) critical splice donor site probably null
R9577:Vipr1 UTSW 9 121,471,993 (GRCm39) critical splice donor site probably null
Posted On 2015-04-16