Incidental Mutation 'IGL02680:Vmn2r16'
ID303319
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r16
Ensembl Gene ENSMUSG00000092080
Gene Namevomeronasal 2, receptor 16
SynonymsEG384220
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.166) question?
Stock #IGL02680
Quality Score
Status
Chromosome5
Chromosomal Location109330381-109364481 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 109340082 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Leucine at position 274 (M274L)
Ref Sequence ENSEMBL: ENSMUSP00000127838 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000165180]
Predicted Effect probably benign
Transcript: ENSMUST00000165180
AA Change: M274L

PolyPhen 2 Score 0.435 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000127838
Gene: ENSMUSG00000092080
AA Change: M274L

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 76 425 2.3e-28 PFAM
Pfam:NCD3G 509 563 8.2e-19 PFAM
Pfam:7tm_3 596 831 3.5e-56 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921524L21Rik T A 18: 6,635,949 probably benign Het
Aldh1a3 C A 7: 66,406,147 V299F probably damaging Het
Ankar A G 1: 72,670,116 Y747H probably damaging Het
Armc9 T C 1: 86,252,278 I107T probably damaging Het
Atmin A T 8: 116,957,497 D632V probably damaging Het
Atp5h C A 11: 115,416,014 probably null Het
Cadps2 T C 6: 23,838,896 E81G probably damaging Het
Cep162 A G 9: 87,246,744 V67A possibly damaging Het
Cfap100 C T 6: 90,412,235 V335I probably benign Het
Dmtf1 A T 5: 9,130,381 D181E probably benign Het
Efcab14 T A 4: 115,740,418 I70N probably damaging Het
Frzb T C 2: 80,424,626 T189A possibly damaging Het
Fstl3 G A 10: 79,778,672 W69* probably null Het
Gjb3 C T 4: 127,326,022 C239Y probably damaging Het
Ifna1 A G 4: 88,850,286 D67G probably benign Het
Inpp5d A G 1: 87,701,483 T397A possibly damaging Het
Myh11 G T 16: 14,209,520 H1283Q probably benign Het
Naip6 A G 13: 100,283,748 V1338A probably benign Het
Obscn A G 11: 59,000,020 S7229P unknown Het
Olfr364-ps1 A T 2: 37,146,415 I68F probably damaging Het
Pfkp G A 13: 6,600,672 probably benign Het
Pop1 T A 15: 34,502,473 I102K probably damaging Het
Ppp1r21 A G 17: 88,583,862 M732V probably benign Het
Rsc1a1 A G 4: 141,685,097 V168A probably benign Het
Scd2 G A 19: 44,301,246 V227I probably benign Het
Scn10a T A 9: 119,666,059 Y372F probably damaging Het
Slc35c2 G T 2: 165,282,135 T94K probably damaging Het
Slc41a2 A G 10: 83,283,864 Y345H probably benign Het
Slc5a11 T C 7: 123,265,631 S387P probably damaging Het
Smg7 T A 1: 152,845,394 N727I probably benign Het
Steap2 A T 5: 5,673,474 F469I probably benign Het
Tex2 T A 11: 106,568,232 probably benign Het
Tmem79 A G 3: 88,332,963 L226P probably damaging Het
Tnfrsf14 G T 4: 154,924,470 C165* probably null Het
Trim21 A G 7: 102,559,663 V283A probably benign Het
Other mutations in Vmn2r16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01116:Vmn2r16 APN 5 109340428 missense probably damaging 1.00
IGL01374:Vmn2r16 APN 5 109330417 missense probably benign 0.00
IGL01391:Vmn2r16 APN 5 109363761 missense possibly damaging 0.50
IGL01419:Vmn2r16 APN 5 109362401 splice site probably benign
IGL01634:Vmn2r16 APN 5 109340311 missense probably benign 0.00
IGL01845:Vmn2r16 APN 5 109363896 missense probably damaging 1.00
IGL01875:Vmn2r16 APN 5 109330411 missense probably benign 0.01
IGL01910:Vmn2r16 APN 5 109340085 missense probably damaging 1.00
IGL02217:Vmn2r16 APN 5 109339810 missense probably damaging 0.98
IGL02327:Vmn2r16 APN 5 109340121 missense probably benign 0.01
IGL02491:Vmn2r16 APN 5 109339837 nonsense probably null
IGL02531:Vmn2r16 APN 5 109340268 missense probably damaging 0.99
IGL02884:Vmn2r16 APN 5 109360891 missense possibly damaging 0.94
IGL03084:Vmn2r16 APN 5 109330426 missense probably damaging 0.99
IGL03096:Vmn2r16 APN 5 109339885 missense probably damaging 0.99
IGL03355:Vmn2r16 APN 5 109363714 missense possibly damaging 0.74
R0280:Vmn2r16 UTSW 5 109340139 missense possibly damaging 0.88
R0594:Vmn2r16 UTSW 5 109363896 missense probably damaging 1.00
R1016:Vmn2r16 UTSW 5 109339888 missense probably damaging 1.00
R1109:Vmn2r16 UTSW 5 109339786 missense probably damaging 0.98
R1248:Vmn2r16 UTSW 5 109360777 missense probably benign 0.10
R1626:Vmn2r16 UTSW 5 109363577 missense probably damaging 1.00
R1909:Vmn2r16 UTSW 5 109363987 missense probably benign 0.01
R1929:Vmn2r16 UTSW 5 109339258 missense possibly damaging 0.92
R1982:Vmn2r16 UTSW 5 109364024 missense probably benign 0.01
R3038:Vmn2r16 UTSW 5 109339333 missense probably damaging 1.00
R3437:Vmn2r16 UTSW 5 109330496 missense probably damaging 0.99
R3734:Vmn2r16 UTSW 5 109330414 missense probably benign 0.11
R3820:Vmn2r16 UTSW 5 109362277 missense probably benign 0.36
R3873:Vmn2r16 UTSW 5 109340311 missense probably benign 0.33
R4165:Vmn2r16 UTSW 5 109330561 missense possibly damaging 0.80
R4373:Vmn2r16 UTSW 5 109363801 missense probably damaging 1.00
R4575:Vmn2r16 UTSW 5 109363799 missense possibly damaging 0.81
R4576:Vmn2r16 UTSW 5 109363799 missense possibly damaging 0.81
R4578:Vmn2r16 UTSW 5 109363799 missense possibly damaging 0.81
R4637:Vmn2r16 UTSW 5 109330414 missense probably benign 0.00
R4696:Vmn2r16 UTSW 5 109339302 missense probably benign 0.01
R5026:Vmn2r16 UTSW 5 109360856 nonsense probably null
R5180:Vmn2r16 UTSW 5 109330525 missense probably benign 0.01
R5433:Vmn2r16 UTSW 5 109363842 missense probably damaging 1.00
R5955:Vmn2r16 UTSW 5 109363747 missense possibly damaging 0.78
R5958:Vmn2r16 UTSW 5 109362287 missense possibly damaging 0.81
R6353:Vmn2r16 UTSW 5 109340253 missense probably benign 0.33
R6389:Vmn2r16 UTSW 5 109330478 missense probably benign 0.19
R6819:Vmn2r16 UTSW 5 109340546 missense probably benign 0.04
X0027:Vmn2r16 UTSW 5 109339309 missense probably damaging 1.00
Z1088:Vmn2r16 UTSW 5 109340515 missense probably benign 0.03
Z1088:Vmn2r16 UTSW 5 109363913 frame shift probably null
Posted On2015-04-16