Incidental Mutation 'IGL02681:Klra10'
| ID |
303353 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Klra10
|
| Ensembl Gene |
ENSMUSG00000072718 |
| Gene Name |
killer cell lectin-like receptor subfamily A, member 10 |
| Synonyms |
Ly49i2, Ly49J |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.051)
|
| Stock # |
IGL02681
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
130246157-130258891 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 130256382 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Leucine
at position 91
(M91L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000107651
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000112020]
|
| AlphaFold |
Q9R1G6 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000112020
AA Change: M91L
PolyPhen 2
Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000107651
Gene: ENSMUSG00000072718
AA Change: M91L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
56 |
66 |
N/A |
INTRINSIC |
|
Blast:CLECT
|
73 |
117 |
2e-9 |
BLAST |
|
CLECT
|
143 |
258 |
6.43e-14 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 26 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Bcar3 |
C |
T |
3: 122,306,417 (GRCm39) |
|
probably null |
Het |
| Cyp3a59 |
T |
C |
5: 146,027,556 (GRCm39) |
|
probably benign |
Het |
| Dnah2 |
G |
A |
11: 69,343,759 (GRCm39) |
T2844M |
probably benign |
Het |
| Ehbp1l1 |
T |
C |
19: 5,770,853 (GRCm39) |
I241M |
probably damaging |
Het |
| Fancl |
G |
A |
11: 26,418,722 (GRCm39) |
|
probably null |
Het |
| Filip1l |
A |
G |
16: 57,392,142 (GRCm39) |
Q910R |
probably benign |
Het |
| Fn1 |
A |
T |
1: 71,658,641 (GRCm39) |
V1139E |
probably damaging |
Het |
| Gm4787 |
A |
G |
12: 81,425,543 (GRCm39) |
V205A |
possibly damaging |
Het |
| Gpr158 |
T |
A |
2: 21,820,441 (GRCm39) |
L646Q |
probably damaging |
Het |
| Ifna1 |
A |
G |
4: 88,768,523 (GRCm39) |
D67G |
probably benign |
Het |
| Il11ra1 |
T |
A |
4: 41,768,552 (GRCm39) |
M412K |
possibly damaging |
Het |
| Krba1 |
T |
A |
6: 48,381,052 (GRCm39) |
D129E |
probably damaging |
Het |
| Mat1a |
T |
C |
14: 40,844,453 (GRCm39) |
|
probably benign |
Het |
| Med24 |
T |
A |
11: 98,600,565 (GRCm39) |
K627* |
probably null |
Het |
| Mpl |
A |
T |
4: 118,306,068 (GRCm39) |
|
probably benign |
Het |
| Mynn |
T |
A |
3: 30,670,791 (GRCm39) |
D554E |
probably benign |
Het |
| Niban2 |
A |
G |
2: 32,801,402 (GRCm39) |
Y122C |
probably benign |
Het |
| Or1e23 |
T |
C |
11: 73,407,356 (GRCm39) |
Y223C |
probably benign |
Het |
| Prkcd |
T |
C |
14: 30,323,190 (GRCm39) |
|
probably null |
Het |
| Prrc2c |
T |
C |
1: 162,533,181 (GRCm39) |
|
probably benign |
Het |
| Scp2d1 |
T |
C |
2: 144,665,804 (GRCm39) |
F48L |
probably benign |
Het |
| Slc12a2 |
A |
G |
18: 58,012,471 (GRCm39) |
H198R |
probably benign |
Het |
| Sulf2 |
A |
G |
2: 165,958,905 (GRCm39) |
V101A |
probably benign |
Het |
| Synj2 |
T |
A |
17: 6,040,611 (GRCm39) |
V144E |
probably damaging |
Het |
| Tas2r113 |
T |
G |
6: 132,870,330 (GRCm39) |
F119L |
probably damaging |
Het |
| Tspan17 |
A |
G |
13: 54,937,442 (GRCm39) |
E12G |
probably damaging |
Het |
|
| Other mutations in Klra10 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01505:Klra10
|
APN |
6 |
130,249,680 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02060:Klra10
|
APN |
6 |
130,249,688 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02249:Klra10
|
APN |
6 |
130,256,367 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL02684:Klra10
|
APN |
6 |
130,258,845 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
FR4342:Klra10
|
UTSW |
6 |
130,249,710 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0324:Klra10
|
UTSW |
6 |
130,249,613 (GRCm39) |
splice site |
probably null |
|
|
R1072:Klra10
|
UTSW |
6 |
130,258,811 (GRCm39) |
missense |
probably benign |
0.11 |
|
R1466:Klra10
|
UTSW |
6 |
130,256,394 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1466:Klra10
|
UTSW |
6 |
130,256,394 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1466:Klra10
|
UTSW |
6 |
130,256,278 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1466:Klra10
|
UTSW |
6 |
130,256,278 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2125:Klra10
|
UTSW |
6 |
130,256,241 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2266:Klra10
|
UTSW |
6 |
130,246,264 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2427:Klra10
|
UTSW |
6 |
130,256,298 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4260:Klra10
|
UTSW |
6 |
130,249,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4495:Klra10
|
UTSW |
6 |
130,256,311 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5897:Klra10
|
UTSW |
6 |
130,258,792 (GRCm39) |
nonsense |
probably null |
|
|
R6123:Klra10
|
UTSW |
6 |
130,256,339 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6221:Klra10
|
UTSW |
6 |
130,246,235 (GRCm39) |
missense |
probably benign |
|
|
R6478:Klra10
|
UTSW |
6 |
130,249,507 (GRCm39) |
splice site |
probably null |
|
|
R6520:Klra10
|
UTSW |
6 |
130,252,755 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6551:Klra10
|
UTSW |
6 |
130,252,718 (GRCm39) |
missense |
probably benign |
0.36 |
|
R7445:Klra10
|
UTSW |
6 |
130,252,819 (GRCm39) |
missense |
probably benign |
0.38 |
|
R7453:Klra10
|
UTSW |
6 |
130,257,327 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7744:Klra10
|
UTSW |
6 |
130,249,724 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8079:Klra10
|
UTSW |
6 |
130,252,738 (GRCm39) |
missense |
probably benign |
|
|
R8320:Klra10
|
UTSW |
6 |
130,246,211 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8963:Klra10
|
UTSW |
6 |
130,249,617 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9419:Klra10
|
UTSW |
6 |
130,256,435 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9725:Klra10
|
UTSW |
6 |
130,252,849 (GRCm39) |
missense |
probably benign |
|
|
RF060:Klra10
|
UTSW |
6 |
130,252,784 (GRCm39) |
small deletion |
probably benign |
|
|
| Posted On |
2015-04-16 |
Incidental Mutation