Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02681:Cyp3a59'

303376

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cyp3a59

Ensembl Gene

ENSMUSG00000061292

Gene Name

cytochrome P450, family 3, subfamily a, polypeptide 59

Synonyms

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL02681

Quality Score

Status

Chromosome

Chromosomal Location

146016067-146050097 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 146027556 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000142591 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000035571] [ENSMUST00000199212]

AlphaFold

D3Z2W7

Predicted Effect

probably benign
Transcript: ENSMUST00000035571

SMART Domains

Protein: ENSMUSP00000049494
Gene: ENSMUSG00000061292

Domain	Start	End	E-Value	Type
Pfam:p450	38	493	5.3e-128	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000199212

SMART Domains

Protein: ENSMUSP00000142591
Gene: ENSMUSG00000061292

Domain	Start	End	E-Value	Type
signal peptide	1	29	N/A	INTRINSIC
Pfam:p450	38	148	3.3e-20	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 26 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Bcar3	C	T	3: 122,306,417 (GRCm39)		probably null	Het
Dnah2	G	A	11: 69,343,759 (GRCm39)	T2844M	probably benign	Het
Ehbp1l1	T	C	19: 5,770,853 (GRCm39)	I241M	probably damaging	Het
Fancl	G	A	11: 26,418,722 (GRCm39)		probably null	Het
Filip1l	A	G	16: 57,392,142 (GRCm39)	Q910R	probably benign	Het
Fn1	A	T	1: 71,658,641 (GRCm39)	V1139E	probably damaging	Het
Gm4787	A	G	12: 81,425,543 (GRCm39)	V205A	possibly damaging	Het
Gpr158	T	A	2: 21,820,441 (GRCm39)	L646Q	probably damaging	Het
Ifna1	A	G	4: 88,768,523 (GRCm39)	D67G	probably benign	Het
Il11ra1	T	A	4: 41,768,552 (GRCm39)	M412K	possibly damaging	Het
Klra10	T	A	6: 130,256,382 (GRCm39)	M91L	probably damaging	Het
Krba1	T	A	6: 48,381,052 (GRCm39)	D129E	probably damaging	Het
Mat1a	T	C	14: 40,844,453 (GRCm39)		probably benign	Het
Med24	T	A	11: 98,600,565 (GRCm39)	K627*	probably null	Het
Mpl	A	T	4: 118,306,068 (GRCm39)		probably benign	Het
Mynn	T	A	3: 30,670,791 (GRCm39)	D554E	probably benign	Het
Niban2	A	G	2: 32,801,402 (GRCm39)	Y122C	probably benign	Het
Or1e23	T	C	11: 73,407,356 (GRCm39)	Y223C	probably benign	Het
Prkcd	T	C	14: 30,323,190 (GRCm39)		probably null	Het
Prrc2c	T	C	1: 162,533,181 (GRCm39)		probably benign	Het
Scp2d1	T	C	2: 144,665,804 (GRCm39)	F48L	probably benign	Het
Slc12a2	A	G	18: 58,012,471 (GRCm39)	H198R	probably benign	Het
Sulf2	A	G	2: 165,958,905 (GRCm39)	V101A	probably benign	Het
Synj2	T	A	17: 6,040,611 (GRCm39)	V144E	probably damaging	Het
Tas2r113	T	G	6: 132,870,330 (GRCm39)	F119L	probably damaging	Het
Tspan17	A	G	13: 54,937,442 (GRCm39)	E12G	probably damaging	Het

Other mutations in Cyp3a59

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01120:Cyp3a59	APN	5	146,039,671 (GRCm39)	missense	probably damaging	0.99
IGL01129:Cyp3a59	APN	5	146,035,089 (GRCm39)	missense	probably benign	0.06
IGL01628:Cyp3a59	APN	5	146,036,629 (GRCm39)	missense	possibly damaging	0.94
IGL01982:Cyp3a59	APN	5	146,041,545 (GRCm39)	missense	probably benign	0.00
IGL02094:Cyp3a59	APN	5	146,041,631 (GRCm39)	missense	probably benign	0.05
IGL02140:Cyp3a59	APN	5	146,039,690 (GRCm39)	missense	probably damaging	1.00
IGL02350:Cyp3a59	APN	5	146,016,152 (GRCm39)	missense	probably damaging	1.00
IGL02357:Cyp3a59	APN	5	146,016,152 (GRCm39)	missense	probably damaging	1.00
IGL02445:Cyp3a59	APN	5	146,033,463 (GRCm39)	missense	probably benign	0.00
IGL02870:Cyp3a59	APN	5	146,034,994 (GRCm39)	missense	probably benign
IGL03023:Cyp3a59	APN	5	146,022,660 (GRCm39)	missense	probably benign	0.02
PIT4802001:Cyp3a59	UTSW	5	146,039,611 (GRCm39)	missense	probably benign	0.00
R0220:Cyp3a59	UTSW	5	146,035,080 (GRCm39)	missense	probably benign	0.02
R0532:Cyp3a59	UTSW	5	146,033,463 (GRCm39)	nonsense	probably null
R1084:Cyp3a59	UTSW	5	146,033,484 (GRCm39)	missense	probably benign
R1263:Cyp3a59	UTSW	5	146,041,521 (GRCm39)	missense	probably damaging	1.00
R1573:Cyp3a59	UTSW	5	146,039,684 (GRCm39)	missense	probably damaging	1.00
R1747:Cyp3a59	UTSW	5	146,041,568 (GRCm39)	missense	probably benign
R1759:Cyp3a59	UTSW	5	146,035,060 (GRCm39)	missense	probably benign	0.10
R1812:Cyp3a59	UTSW	5	146,039,621 (GRCm39)	missense	probably damaging	1.00
R1937:Cyp3a59	UTSW	5	146,031,187 (GRCm39)	missense	possibly damaging	0.80
R2026:Cyp3a59	UTSW	5	146,033,098 (GRCm39)	missense	probably damaging	1.00
R2060:Cyp3a59	UTSW	5	146,041,524 (GRCm39)	missense	probably damaging	1.00
R2355:Cyp3a59	UTSW	5	146,036,622 (GRCm39)	missense	probably benign	0.09
R3721:Cyp3a59	UTSW	5	146,033,407 (GRCm39)	missense	probably damaging	0.96
R4013:Cyp3a59	UTSW	5	146,016,193 (GRCm39)	missense	probably benign	0.01
R4421:Cyp3a59	UTSW	5	146,041,713 (GRCm39)	splice site	probably null
R4432:Cyp3a59	UTSW	5	146,041,596 (GRCm39)	missense	probably benign	0.04
R4633:Cyp3a59	UTSW	5	146,031,248 (GRCm39)	missense	probably damaging	1.00
R4843:Cyp3a59	UTSW	5	146,033,071 (GRCm39)	missense	possibly damaging	0.61
R4886:Cyp3a59	UTSW	5	146,024,197 (GRCm39)	missense	probably damaging	1.00
R5236:Cyp3a59	UTSW	5	146,039,635 (GRCm39)	missense	probably benign	0.20
R5386:Cyp3a59	UTSW	5	146,022,578 (GRCm39)	missense	probably benign	0.01
R5627:Cyp3a59	UTSW	5	146,049,664 (GRCm39)	missense	probably benign	0.00
R5792:Cyp3a59	UTSW	5	146,036,661 (GRCm39)	missense	possibly damaging	0.92
R5935:Cyp3a59	UTSW	5	146,027,455 (GRCm39)	nonsense	probably null
R6531:Cyp3a59	UTSW	5	146,035,027 (GRCm39)	missense	probably benign	0.00
R6790:Cyp3a59	UTSW	5	146,033,143 (GRCm39)	missense	probably benign
R7108:Cyp3a59	UTSW	5	146,033,143 (GRCm39)	missense	probably benign
R7222:Cyp3a59	UTSW	5	146,033,385 (GRCm39)	critical splice acceptor site	probably null
R7447:Cyp3a59	UTSW	5	146,024,215 (GRCm39)	missense	probably benign	0.25
R7457:Cyp3a59	UTSW	5	146,041,560 (GRCm39)	missense	probably damaging	1.00
R7723:Cyp3a59	UTSW	5	146,016,154 (GRCm39)	missense	probably benign	0.06
R8171:Cyp3a59	UTSW	5	146,022,584 (GRCm39)	missense	probably damaging	1.00
R8417:Cyp3a59	UTSW	5	146,027,495 (GRCm39)	missense	possibly damaging	0.49
R8474:Cyp3a59	UTSW	5	146,041,487 (GRCm39)	missense	probably benign	0.01
R8716:Cyp3a59	UTSW	5	146,033,411 (GRCm39)	missense	probably damaging	0.99
R8728:Cyp3a59	UTSW	5	146,035,122 (GRCm39)	critical splice donor site	probably null
R8839:Cyp3a59	UTSW	5	146,045,896 (GRCm39)	missense	probably benign
R8969:Cyp3a59	UTSW	5	146,049,630 (GRCm39)	missense	probably benign	0.15
R9478:Cyp3a59	UTSW	5	146,034,997 (GRCm39)	missense	probably damaging	0.98
R9697:Cyp3a59	UTSW	5	146,031,190 (GRCm39)	missense	probably damaging	0.99
R9705:Cyp3a59	UTSW	5	146,033,120 (GRCm39)	missense	probably benign	0.00
Z1088:Cyp3a59	UTSW	5	146,035,032 (GRCm39)	missense	probably benign	0.33

Posted On

2015-04-16