Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02682:Mtg1'

303419

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mtg1

Ensembl Gene

ENSMUSG00000039018

Gene Name

mitochondrial ribosome-associated GTPase 1

Synonyms

LOC212508, Gtpbp7

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL02682

Quality Score

Status

Chromosome

Chromosomal Location

139717477-139730699 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 139724642 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000036977] [ENSMUST00000124253]

AlphaFold

Q8R2R6

Predicted Effect

probably benign
Transcript: ENSMUST00000036977

SMART Domains

Protein: ENSMUSP00000036491
Gene: ENSMUSG00000039018

Domain	Start	End	E-Value	Type
SCOP:d1egaa1	31	129	5e-6	SMART
Pfam:FeoB_N	143	219	3.9e-6	PFAM
Pfam:MMR_HSR1	144	283	2.4e-13	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000124253

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000140579

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000141070

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000150667

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000155723

Predicted Effect

probably benign
Transcript: ENSMUST00000211171

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acvr1	A	G	2: 58,367,823 (GRCm39)	S113P	probably benign	Het
Arhgdib	A	T	6: 136,901,166 (GRCm39)	W188R	probably damaging	Het
Bcr	T	A	10: 75,001,878 (GRCm39)	N927K	possibly damaging	Het
Cd209c	A	G	8: 3,990,324 (GRCm39)	Y165H	probably damaging	Het
Cnnm2	A	G	19: 46,750,515 (GRCm39)	K102E	probably benign	Het
Col12a1	T	C	9: 79,606,623 (GRCm39)	E600G	probably damaging	Het
Ddx4	A	T	13: 112,758,720 (GRCm39)	H280Q	probably benign	Het
Eya4	T	C	10: 22,992,498 (GRCm39)	Y462C	probably damaging	Het
Fibcd1	T	A	2: 31,728,576 (GRCm39)	I94F	probably damaging	Het
Gm4846	C	A	1: 166,322,195 (GRCm39)	G124V	probably damaging	Het
Gm5624	A	G	14: 44,797,469 (GRCm39)	I108T	possibly damaging	Het
Gpr179	A	T	11: 97,242,691 (GRCm39)	M51K	probably benign	Het
Hck	A	G	2: 152,976,054 (GRCm39)	I198V	probably damaging	Het
Kcnd2	T	A	6: 21,216,924 (GRCm39)	C209*	probably null	Het
Klhl1	T	A	14: 96,438,778 (GRCm39)	I507F	possibly damaging	Het
Knl1	A	T	2: 118,908,450 (GRCm39)	K1693N	possibly damaging	Het
Mcam	T	C	9: 44,051,714 (GRCm39)	V490A	possibly damaging	Het
Mrgprx1	A	T	7: 47,671,740 (GRCm39)	D2E	probably damaging	Het
Myof	C	A	19: 37,909,929 (GRCm39)	R1512L	probably benign	Het
Nrp2	C	T	1: 62,810,996 (GRCm39)	T679I	probably benign	Het
Nwd2	C	A	5: 63,962,020 (GRCm39)	L535I	probably benign	Het
Nwd2	T	A	5: 63,962,021 (GRCm39)	L535H	probably damaging	Het
Or4f14b	T	A	2: 111,775,285 (GRCm39)	N172I	probably damaging	Het
Or52j3	A	T	7: 102,836,221 (GRCm39)	I138F	probably damaging	Het
Or5b94	T	C	19: 12,652,033 (GRCm39)	S155P	probably damaging	Het
Phkb	A	G	8: 86,602,275 (GRCm39)	*41W	probably null	Het
Prl5a1	T	A	13: 28,329,403 (GRCm39)	N27K	probably benign	Het
Rims1	T	C	1: 22,358,708 (GRCm39)	T1292A	probably damaging	Het
Rnf38	G	A	4: 44,133,745 (GRCm39)	A376V	probably damaging	Het
Slc34a2	T	C	5: 53,216,580 (GRCm39)	V117A	possibly damaging	Het
Slfn8	A	T	11: 82,894,517 (GRCm39)	F707L	probably damaging	Het
Snx16	G	A	3: 10,503,235 (GRCm39)	P4L	probably damaging	Het
Snx6	T	C	12: 54,801,130 (GRCm39)	D289G	probably damaging	Het
St8sia3	G	T	18: 64,402,750 (GRCm39)	V130F	probably damaging	Het
U2surp	A	G	9: 95,363,704 (GRCm39)		probably null	Het
Ubqln3	A	G	7: 103,791,272 (GRCm39)	F273L	probably benign	Het
Vmn2r101	A	T	17: 19,832,507 (GRCm39)	R834S	possibly damaging	Het
Vmn2r18	G	T	5: 151,508,102 (GRCm39)	H341N	probably damaging	Het
Vrk3	A	G	7: 44,403,244 (GRCm39)	I2V	probably benign	Het
Zglp1	A	G	9: 20,977,534 (GRCm39)	S94P	probably benign	Het

Other mutations in Mtg1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01739:Mtg1	APN	7	139,730,149 (GRCm39)	missense	probably benign	0.00
IGL02105:Mtg1	APN	7	139,730,119 (GRCm39)	missense	probably damaging	1.00
IGL02458:Mtg1	APN	7	139,730,085 (GRCm39)	missense	probably benign	0.01
R0666:Mtg1	UTSW	7	139,724,257 (GRCm39)	missense	probably benign
R0893:Mtg1	UTSW	7	139,729,665 (GRCm39)	missense	probably damaging	1.00
R3707:Mtg1	UTSW	7	139,729,717 (GRCm39)	missense	probably damaging	0.99
R4993:Mtg1	UTSW	7	139,720,196 (GRCm39)	missense	probably null	1.00
R5810:Mtg1	UTSW	7	139,725,898 (GRCm39)	splice site	probably null
R5886:Mtg1	UTSW	7	139,729,778 (GRCm39)	splice site	probably null
R5960:Mtg1	UTSW	7	139,726,906 (GRCm39)	unclassified	probably benign
R7069:Mtg1	UTSW	7	139,723,657 (GRCm39)	missense	probably benign	0.00
R7110:Mtg1	UTSW	7	139,726,779 (GRCm39)	missense	probably benign	0.02
R7492:Mtg1	UTSW	7	139,724,610 (GRCm39)	missense	probably damaging	1.00
R7790:Mtg1	UTSW	7	139,729,662 (GRCm39)	missense	probably damaging	1.00
R7917:Mtg1	UTSW	7	139,727,178 (GRCm39)	missense	probably damaging	1.00
R8155:Mtg1	UTSW	7	139,724,622 (GRCm39)	missense	probably benign	0.07
R8444:Mtg1	UTSW	7	139,718,283 (GRCm39)	missense	probably damaging	1.00
R8713:Mtg1	UTSW	7	139,720,136 (GRCm39)	missense	probably benign	0.12
R8713:Mtg1	UTSW	7	139,717,688 (GRCm39)	critical splice donor site	probably null
R9424:Mtg1	UTSW	7	139,727,212 (GRCm39)	nonsense	probably null

Posted On

2015-04-16