Incidental Mutation 'IGL02684:Klra10'
ID303465
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Klra10
Ensembl Gene ENSMUSG00000072718
Gene Namekiller cell lectin-like receptor subfamily A, member 10
SynonymsLy49i2, Ly49J
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.072) question?
Stock #IGL02684
Quality Score
Status
Chromosome6
Chromosomal Location130269194-130281928 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 130281882 bp
ZygosityHeterozygous
Amino Acid Change Histidine to Leucine at position 14 (H14L)
Ref Sequence ENSEMBL: ENSMUSP00000107651 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000112020]
Predicted Effect possibly damaging
Transcript: ENSMUST00000112020
AA Change: H14L

PolyPhen 2 Score 0.850 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000107651
Gene: ENSMUSG00000072718
AA Change: H14L

DomainStartEndE-ValueType
low complexity region 56 66 N/A INTRINSIC
Blast:CLECT 73 117 2e-9 BLAST
CLECT 143 258 6.43e-14 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930596D02Rik A T 14: 35,810,063 L185* probably null Het
Actrt3 A T 3: 30,599,691 D53E probably benign Het
Ankrd34b T C 13: 92,438,508 S83P probably damaging Het
Asap1 A G 15: 64,094,169 V1029A probably benign Het
Blk T C 14: 63,379,694 E288G probably benign Het
Cep192 T G 18: 67,834,563 V706G probably damaging Het
Chd2 T C 7: 73,475,349 K908E probably damaging Het
Dnm1l A T 16: 16,321,657 I391N possibly damaging Het
Fam84a T C 12: 14,150,645 D27G probably damaging Het
Fmn1 A G 2: 113,525,277 R688G unknown Het
Gdap2 A G 3: 100,171,020 D100G probably benign Het
Gm43638 T C 5: 87,462,910 I522V possibly damaging Het
Gm438 A G 4: 144,778,185 probably benign Het
Gsap A T 5: 21,242,803 probably null Het
Hoxd12 A G 2: 74,675,561 S159G probably benign Het
Ints7 A G 1: 191,613,637 probably null Het
Iqsec3 G A 6: 121,412,941 Q524* probably null Het
Mettl15 T C 2: 109,131,580 E228G probably damaging Het
Olfr466 G A 13: 65,152,396 M57I probably damaging Het
Olfr624 T C 7: 103,670,384 M216V probably benign Het
Pabpc1l A G 2: 164,031,277 N156D probably benign Het
Pkhd1l1 G T 15: 44,516,209 probably null Het
Pm20d1 T A 1: 131,804,959 N345K probably benign Het
Rasgrp1 A G 2: 117,282,576 V785A probably benign Het
Sos2 A G 12: 69,596,666 L980S probably damaging Het
Stam2 A T 2: 52,719,935 H56Q probably damaging Het
Trpm6 T A 19: 18,802,207 probably benign Het
Trpm7 A T 2: 126,846,159 D249E probably damaging Het
Vmn1r203 A T 13: 22,524,369 T107S possibly damaging Het
Vmn2r55 A G 7: 12,670,960 L172P probably damaging Het
Vrtn A G 12: 84,650,149 R558G probably benign Het
Zfp977 A T 7: 42,583,015 D7E probably damaging Het
Other mutations in Klra10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01505:Klra10 APN 6 130272717 missense probably damaging 1.00
IGL02060:Klra10 APN 6 130272725 missense probably damaging 0.99
IGL02249:Klra10 APN 6 130279404 missense probably benign 0.07
IGL02681:Klra10 APN 6 130279419 missense probably damaging 0.98
FR4342:Klra10 UTSW 6 130272747 missense probably benign 0.01
R0324:Klra10 UTSW 6 130272650 splice site probably null
R1072:Klra10 UTSW 6 130281848 missense probably benign 0.11
R1466:Klra10 UTSW 6 130279315 missense probably damaging 1.00
R1466:Klra10 UTSW 6 130279431 missense probably damaging 0.98
R1466:Klra10 UTSW 6 130279315 missense probably damaging 1.00
R1466:Klra10 UTSW 6 130279431 missense probably damaging 0.98
R2125:Klra10 UTSW 6 130279278 missense probably damaging 0.98
R2266:Klra10 UTSW 6 130269301 missense probably benign 0.13
R2427:Klra10 UTSW 6 130279335 missense probably benign 0.00
R4260:Klra10 UTSW 6 130272681 missense probably damaging 1.00
R4495:Klra10 UTSW 6 130279348 missense probably benign 0.00
R5897:Klra10 UTSW 6 130281829 nonsense probably null
R6123:Klra10 UTSW 6 130279376 missense probably benign 0.04
R6221:Klra10 UTSW 6 130269272 missense probably benign
R6478:Klra10 UTSW 6 130272544 intron probably null
R6520:Klra10 UTSW 6 130275792 missense probably benign 0.03
R6551:Klra10 UTSW 6 130275755 missense probably benign 0.36
Posted On2015-04-16