Incidental Mutation 'IGL02684:Mettl15'
ID 303471
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mettl15
Ensembl Gene ENSMUSG00000057234
Gene Name methyltransferase like 15
Synonyms 0610027B03Rik, Mett5d1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.126) question?
Stock # IGL02684
Quality Score
Status
Chromosome 2
Chromosomal Location 108922642-109111093 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 108961925 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 228 (E228G)
Ref Sequence ENSEMBL: ENSMUSP00000116829 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081631] [ENSMUST00000147770]
AlphaFold Q9DCL4
Predicted Effect possibly damaging
Transcript: ENSMUST00000081631
AA Change: E228G

PolyPhen 2 Score 0.896 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000080337
Gene: ENSMUSG00000057234
AA Change: E228G

DomainStartEndE-ValueType
Pfam:Methyltransf_5 69 406 1.5e-90 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147376
Predicted Effect probably damaging
Transcript: ENSMUST00000147770
AA Change: E228G

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000116829
Gene: ENSMUSG00000057234
AA Change: E228G

DomainStartEndE-ValueType
Pfam:Methyltransf_5 69 230 1.6e-47 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930596D02Rik A T 14: 35,532,020 (GRCm39) L185* probably null Het
Aadacl4fm5 A G 4: 144,504,755 (GRCm39) probably benign Het
Actrt3 A T 3: 30,653,840 (GRCm39) D53E probably benign Het
Ankrd34b T C 13: 92,575,016 (GRCm39) S83P probably damaging Het
Asap1 A G 15: 63,966,018 (GRCm39) V1029A probably benign Het
Blk T C 14: 63,617,143 (GRCm39) E288G probably benign Het
Cep192 T G 18: 67,967,634 (GRCm39) V706G probably damaging Het
Chd2 T C 7: 73,125,097 (GRCm39) K908E probably damaging Het
Dnm1l A T 16: 16,139,521 (GRCm39) I391N possibly damaging Het
Fmn1 A G 2: 113,355,622 (GRCm39) R688G unknown Het
Gdap2 A G 3: 100,078,336 (GRCm39) D100G probably benign Het
Gm43638 T C 5: 87,610,769 (GRCm39) I522V possibly damaging Het
Gsap A T 5: 21,447,801 (GRCm39) probably null Het
Hoxd12 A G 2: 74,505,905 (GRCm39) S159G probably benign Het
Ints7 A G 1: 191,345,749 (GRCm39) probably null Het
Iqsec3 G A 6: 121,389,900 (GRCm39) Q524* probably null Het
Klra10 T A 6: 130,258,845 (GRCm39) H14L possibly damaging Het
Lratd1 T C 12: 14,200,646 (GRCm39) D27G probably damaging Het
Or51v8 T C 7: 103,319,591 (GRCm39) M216V probably benign Het
Or9s18 G A 13: 65,300,210 (GRCm39) M57I probably damaging Het
Pabpc1l A G 2: 163,873,197 (GRCm39) N156D probably benign Het
Pkhd1l1 G T 15: 44,379,605 (GRCm39) probably null Het
Pm20d1 T A 1: 131,732,697 (GRCm39) N345K probably benign Het
Rasgrp1 A G 2: 117,113,057 (GRCm39) V785A probably benign Het
Sos2 A G 12: 69,643,440 (GRCm39) L980S probably damaging Het
Stam2 A T 2: 52,609,947 (GRCm39) H56Q probably damaging Het
Trpm6 T A 19: 18,779,571 (GRCm39) probably benign Het
Trpm7 A T 2: 126,688,079 (GRCm39) D249E probably damaging Het
Vmn1r203 A T 13: 22,708,539 (GRCm39) T107S possibly damaging Het
Vmn2r55 A G 7: 12,404,887 (GRCm39) L172P probably damaging Het
Vrtn A G 12: 84,696,923 (GRCm39) R558G probably benign Het
Zfp977 A T 7: 42,232,439 (GRCm39) D7E probably damaging Het
Other mutations in Mettl15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00155:Mettl15 APN 2 108,923,521 (GRCm39) nonsense probably null
IGL00657:Mettl15 APN 2 108,923,552 (GRCm39) missense probably damaging 1.00
IGL03367:Mettl15 APN 2 108,961,916 (GRCm39) missense probably benign 0.10
R1433:Mettl15 UTSW 2 108,923,266 (GRCm39) missense probably benign 0.00
R1538:Mettl15 UTSW 2 108,962,010 (GRCm39) critical splice acceptor site probably null
R3890:Mettl15 UTSW 2 109,021,924 (GRCm39) missense probably benign 0.03
R5464:Mettl15 UTSW 2 109,021,967 (GRCm39) missense probably benign 0.00
R6609:Mettl15 UTSW 2 108,967,687 (GRCm39) missense probably null 1.00
R7619:Mettl15 UTSW 2 108,923,220 (GRCm39) nonsense probably null
R7737:Mettl15 UTSW 2 108,967,723 (GRCm39) missense probably damaging 0.99
R8914:Mettl15 UTSW 2 108,967,625 (GRCm39) intron probably benign
R9121:Mettl15 UTSW 2 109,104,948 (GRCm39) missense
R9159:Mettl15 UTSW 2 108,923,444 (GRCm39) missense probably damaging 1.00
R9192:Mettl15 UTSW 2 109,104,810 (GRCm39) nonsense probably null
R9364:Mettl15 UTSW 2 108,961,960 (GRCm39) missense probably benign 0.06
R9566:Mettl15 UTSW 2 108,923,592 (GRCm39) missense possibly damaging 0.61
Posted On 2015-04-16