Incidental Mutation 'IGL02684:Zfp977'
| ID |
303473 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp977
|
| Ensembl Gene |
ENSMUSG00000092335 |
| Gene Name |
zinc finger protein 977 |
| Synonyms |
Gm7221 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.248)
|
| Stock # |
IGL02684
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
42229207-42241971 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 42232439 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glutamic Acid
at position 7
(D7E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000134517
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000173283]
[ENSMUST00000179470]
|
| AlphaFold |
L7N2E7 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000173283
AA Change: D7E
PolyPhen 2
Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000134517
Gene: ENSMUSG00000092335
AA Change: D7E
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
66 |
3.82e-20 |
SMART |
|
ZnF_C2H2
|
131 |
153 |
1.92e-2 |
SMART |
|
ZnF_C2H2
|
159 |
181 |
6.32e-3 |
SMART |
|
ZnF_C2H2
|
187 |
209 |
5.99e-4 |
SMART |
|
ZnF_C2H2
|
215 |
237 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
243 |
265 |
7.15e-2 |
SMART |
|
ZnF_C2H2
|
271 |
293 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
299 |
321 |
5.5e-3 |
SMART |
|
ZnF_C2H2
|
327 |
349 |
2.75e-3 |
SMART |
|
ZnF_C2H2
|
355 |
377 |
3.11e-2 |
SMART |
|
ZnF_C2H2
|
383 |
405 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
411 |
433 |
1.82e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000179470
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000205970
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 32 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930596D02Rik |
A |
T |
14: 35,532,020 (GRCm39) |
L185* |
probably null |
Het |
| Aadacl4fm5 |
A |
G |
4: 144,504,755 (GRCm39) |
|
probably benign |
Het |
| Actrt3 |
A |
T |
3: 30,653,840 (GRCm39) |
D53E |
probably benign |
Het |
| Ankrd34b |
T |
C |
13: 92,575,016 (GRCm39) |
S83P |
probably damaging |
Het |
| Asap1 |
A |
G |
15: 63,966,018 (GRCm39) |
V1029A |
probably benign |
Het |
| Blk |
T |
C |
14: 63,617,143 (GRCm39) |
E288G |
probably benign |
Het |
| Cep192 |
T |
G |
18: 67,967,634 (GRCm39) |
V706G |
probably damaging |
Het |
| Chd2 |
T |
C |
7: 73,125,097 (GRCm39) |
K908E |
probably damaging |
Het |
| Dnm1l |
A |
T |
16: 16,139,521 (GRCm39) |
I391N |
possibly damaging |
Het |
| Fmn1 |
A |
G |
2: 113,355,622 (GRCm39) |
R688G |
unknown |
Het |
| Gdap2 |
A |
G |
3: 100,078,336 (GRCm39) |
D100G |
probably benign |
Het |
| Gm43638 |
T |
C |
5: 87,610,769 (GRCm39) |
I522V |
possibly damaging |
Het |
| Gsap |
A |
T |
5: 21,447,801 (GRCm39) |
|
probably null |
Het |
| Hoxd12 |
A |
G |
2: 74,505,905 (GRCm39) |
S159G |
probably benign |
Het |
| Ints7 |
A |
G |
1: 191,345,749 (GRCm39) |
|
probably null |
Het |
| Iqsec3 |
G |
A |
6: 121,389,900 (GRCm39) |
Q524* |
probably null |
Het |
| Klra10 |
T |
A |
6: 130,258,845 (GRCm39) |
H14L |
possibly damaging |
Het |
| Lratd1 |
T |
C |
12: 14,200,646 (GRCm39) |
D27G |
probably damaging |
Het |
| Mettl15 |
T |
C |
2: 108,961,925 (GRCm39) |
E228G |
probably damaging |
Het |
| Or51v8 |
T |
C |
7: 103,319,591 (GRCm39) |
M216V |
probably benign |
Het |
| Or9s18 |
G |
A |
13: 65,300,210 (GRCm39) |
M57I |
probably damaging |
Het |
| Pabpc1l |
A |
G |
2: 163,873,197 (GRCm39) |
N156D |
probably benign |
Het |
| Pkhd1l1 |
G |
T |
15: 44,379,605 (GRCm39) |
|
probably null |
Het |
| Pm20d1 |
T |
A |
1: 131,732,697 (GRCm39) |
N345K |
probably benign |
Het |
| Rasgrp1 |
A |
G |
2: 117,113,057 (GRCm39) |
V785A |
probably benign |
Het |
| Sos2 |
A |
G |
12: 69,643,440 (GRCm39) |
L980S |
probably damaging |
Het |
| Stam2 |
A |
T |
2: 52,609,947 (GRCm39) |
H56Q |
probably damaging |
Het |
| Trpm6 |
T |
A |
19: 18,779,571 (GRCm39) |
|
probably benign |
Het |
| Trpm7 |
A |
T |
2: 126,688,079 (GRCm39) |
D249E |
probably damaging |
Het |
| Vmn1r203 |
A |
T |
13: 22,708,539 (GRCm39) |
T107S |
possibly damaging |
Het |
| Vmn2r55 |
A |
G |
7: 12,404,887 (GRCm39) |
L172P |
probably damaging |
Het |
| Vrtn |
A |
G |
12: 84,696,923 (GRCm39) |
R558G |
probably benign |
Het |
|
| Other mutations in Zfp977 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01350:Zfp977
|
APN |
7 |
42,230,090 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01541:Zfp977
|
APN |
7 |
42,230,156 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02034:Zfp977
|
APN |
7 |
42,230,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02678:Zfp977
|
APN |
7 |
42,232,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03178:Zfp977
|
APN |
7 |
42,232,072 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0707:Zfp977
|
UTSW |
7 |
42,229,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1640:Zfp977
|
UTSW |
7 |
42,229,530 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1668:Zfp977
|
UTSW |
7 |
42,230,070 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1993:Zfp977
|
UTSW |
7 |
42,229,409 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3151:Zfp977
|
UTSW |
7 |
42,229,870 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4587:Zfp977
|
UTSW |
7 |
42,229,614 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4678:Zfp977
|
UTSW |
7 |
42,229,437 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6073:Zfp977
|
UTSW |
7 |
42,230,165 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7054:Zfp977
|
UTSW |
7 |
42,229,786 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7436:Zfp977
|
UTSW |
7 |
42,229,884 (GRCm39) |
missense |
probably benign |
|
|
R7500:Zfp977
|
UTSW |
7 |
42,229,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8294:Zfp977
|
UTSW |
7 |
42,229,689 (GRCm39) |
missense |
probably benign |
|
|
R8418:Zfp977
|
UTSW |
7 |
42,229,410 (GRCm39) |
missense |
probably benign |
|
|
R8439:Zfp977
|
UTSW |
7 |
42,230,102 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8995:Zfp977
|
UTSW |
7 |
42,232,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9005:Zfp977
|
UTSW |
7 |
42,230,082 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9369:Zfp977
|
UTSW |
7 |
42,229,518 (GRCm39) |
missense |
probably damaging |
0.99 |
|
X0023:Zfp977
|
UTSW |
7 |
42,229,543 (GRCm39) |
nonsense |
probably null |
|
|
| Posted On |
2015-04-16 |
Incidental Mutation