Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02686:Vmn2r20'

303546

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r20

Ensembl Gene

ENSMUSG00000094145

Gene Name

vomeronasal 2, receptor 20

Synonyms

EG667180

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.563) question?

Stock #

IGL02686

Quality Score

Status

Chromosome

Chromosomal Location

123362221-123395020 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 123362585 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Threonine at position 733 (M733T)

Ref Sequence

ENSEMBL: ENSMUSP00000129145 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172199]

AlphaFold

L7N2B1

Predicted Effect

probably benign
Transcript: ENSMUST00000172199
AA Change: M733T

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000129145
Gene: ENSMUSG00000094145
AA Change: M733T

Domain	Start	End	E-Value	Type
signal peptide	1	17	N/A	INTRINSIC
Pfam:ANF_receptor	81	473	5e-33	PFAM
Pfam:NCD3G	517	570	9.6e-24	PFAM
Pfam:7tm_3	601	838	1.4e-54	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam4	C	T	12: 81,468,448 (GRCm39)	G58S	possibly damaging	Het
Adcyap1r1	G	A	6: 55,458,110 (GRCm39)	A304T	probably benign	Het
Adipoq	A	G	16: 22,975,865 (GRCm39)	T110A	possibly damaging	Het
Ago2	T	C	15: 72,985,591 (GRCm39)	Y668C	possibly damaging	Het
Ampd2	A	T	3: 107,983,811 (GRCm39)	D575E	possibly damaging	Het
Anxa5	C	T	3: 36,503,504 (GRCm39)	E317K	probably benign	Het
Atf2	A	T	2: 73,675,844 (GRCm39)	M169K	possibly damaging	Het
Bicc1	C	A	10: 70,779,190 (GRCm39)		probably benign	Het
Bicra	A	G	7: 15,721,840 (GRCm39)	M559T	probably benign	Het
Bltp3a	T	C	17: 28,113,563 (GRCm39)	I1245T	probably benign	Het
Bltp3b	A	T	10: 89,641,055 (GRCm39)	Q742L	probably benign	Het
Cacna1e	G	A	1: 154,369,155 (GRCm39)	A294V	probably damaging	Het
Cacna1h	G	A	17: 25,604,723 (GRCm39)	P1197S	possibly damaging	Het
Cmya5	G	A	13: 93,227,505 (GRCm39)	Q2528*	probably null	Het
Csgalnact1	C	A	8: 68,854,144 (GRCm39)	G219V	probably damaging	Het
Cts8	T	C	13: 61,398,784 (GRCm39)	T241A	probably benign	Het
Cubn	T	C	2: 13,330,037 (GRCm39)	I2615V	possibly damaging	Het
Cxcl12	A	G	6: 117,150,546 (GRCm39)		probably benign	Het
Fig4	T	C	10: 41,140,000 (GRCm39)	D307G	probably damaging	Het
Flt1	T	C	5: 147,525,412 (GRCm39)	I909V	probably damaging	Het
Foxk1	T	A	5: 142,439,340 (GRCm39)	S427T	probably damaging	Het
Gosr1	G	A	11: 76,641,688 (GRCm39)	T130M	probably benign	Het
Grik1	G	T	16: 87,806,649 (GRCm39)		probably null	Het
Hipk1	C	T	3: 103,685,333 (GRCm39)	S94N	possibly damaging	Het
Ints7	T	C	1: 191,318,704 (GRCm39)	L147P	probably damaging	Het
Nsd3	A	G	8: 26,156,086 (GRCm39)	D551G	probably damaging	Het
Or11g25	G	A	14: 50,723,426 (GRCm39)	M170I	probably benign	Het
Or5p81	A	T	7: 108,267,093 (GRCm39)	I157F	probably benign	Het
Prrc2c	T	C	1: 162,535,516 (GRCm39)		probably benign	Het
Ren1	A	T	1: 133,286,207 (GRCm39)	N250I	possibly damaging	Het
Ripply2	A	C	9: 86,898,009 (GRCm39)		probably benign	Het
Ryr1	G	T	7: 28,768,975 (GRCm39)		probably benign	Het
Smad3	T	A	9: 63,575,064 (GRCm39)	K51M	probably damaging	Het
Snapc1	C	A	12: 74,011,370 (GRCm39)		probably benign	Het
Srfbp1	T	G	18: 52,608,726 (GRCm39)	V42G	probably damaging	Het
Srrm1	G	A	4: 135,052,415 (GRCm39)	P658L	unknown	Het
Tab1	T	C	15: 80,033,031 (GRCm39)	V105A	probably benign	Het
Tat	T	C	8: 110,723,481 (GRCm39)	V323A	probably damaging	Het
Tdo2	T	C	3: 81,875,462 (GRCm39)	N164S	probably benign	Het
Tefm	T	A	11: 80,027,722 (GRCm39)	L345F	probably damaging	Het
Tmem145	C	A	7: 25,014,150 (GRCm39)	N407K	probably damaging	Het
Vmn2r116	A	G	17: 23,607,767 (GRCm39)	N445S	probably damaging	Het
Vmn2r93	G	A	17: 18,533,526 (GRCm39)	V477M	possibly damaging	Het
Zdhhc4	A	G	5: 143,306,146 (GRCm39)	F194S	probably damaging	Het
Zfp738	A	T	13: 67,821,771 (GRCm39)	S25T	probably damaging	Het

Other mutations in Vmn2r20

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01915:Vmn2r20	APN	6	123,370,924 (GRCm39)	missense	possibly damaging	0.89
IGL02653:Vmn2r20	APN	6	123,362,324 (GRCm39)	missense	probably damaging	1.00
R0309:Vmn2r20	UTSW	6	123,363,063 (GRCm39)	missense	probably benign	0.18
R3724:Vmn2r20	UTSW	6	123,362,706 (GRCm39)	missense	probably benign	0.00
R6502:Vmn2r20	UTSW	6	123,373,342 (GRCm39)	missense	possibly damaging	0.51
R7039:Vmn2r20	UTSW	6	123,363,082 (GRCm39)	missense	probably damaging	0.98
R7218:Vmn2r20	UTSW	6	123,363,074 (GRCm39)	missense	probably damaging	1.00
R7372:Vmn2r20	UTSW	6	123,362,468 (GRCm39)	missense	probably damaging	1.00
R7509:Vmn2r20	UTSW	6	123,362,382 (GRCm39)	missense	probably benign	0.00
R7832:Vmn2r20	UTSW	6	123,362,882 (GRCm39)	missense	probably damaging	1.00
R8011:Vmn2r20	UTSW	6	123,373,369 (GRCm39)	missense	possibly damaging	0.71
R8118:Vmn2r20	UTSW	6	123,373,429 (GRCm39)	missense	probably damaging	1.00
R8839:Vmn2r20	UTSW	6	123,373,515 (GRCm39)	missense	possibly damaging	0.95
R9275:Vmn2r20	UTSW	6	123,362,394 (GRCm39)	missense	probably damaging	1.00
R9743:Vmn2r20	UTSW	6	123,373,369 (GRCm39)	missense	probably damaging	0.99

Posted On

2015-04-16