Incidental Mutation 'IGL02686:Or11g25'
ID 303559
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or11g25
Ensembl Gene ENSMUSG00000095765
Gene Name olfactory receptor family 11 subfamily G member 25
Synonyms MOR106-15, MOR106-10, Olfr741, GA_x6K02T2PMLR-6197851-6198786
Accession Numbers
Essential gene? Probably non essential (E-score: 0.093) question?
Stock # IGL02686
Quality Score
Status
Chromosome 14
Chromosomal Location 50710514-50723852 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 50723426 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 170 (M170I)
Ref Sequence ENSEMBL: ENSMUSP00000151020 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071932] [ENSMUST00000205518] [ENSMUST00000213903]
AlphaFold L7N1Y5
Predicted Effect probably benign
Transcript: ENSMUST00000071932
AA Change: M170I

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000071824
Gene: ENSMUSG00000095765
AA Change: M170I

DomainStartEndE-ValueType
Pfam:7tm_4 35 311 1.2e-55 PFAM
Pfam:7tm_1 45 294 2.4e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000205518
AA Change: M170I

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
Predicted Effect probably benign
Transcript: ENSMUST00000213903
AA Change: M170I

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam4 C T 12: 81,468,448 (GRCm39) G58S possibly damaging Het
Adcyap1r1 G A 6: 55,458,110 (GRCm39) A304T probably benign Het
Adipoq A G 16: 22,975,865 (GRCm39) T110A possibly damaging Het
Ago2 T C 15: 72,985,591 (GRCm39) Y668C possibly damaging Het
Ampd2 A T 3: 107,983,811 (GRCm39) D575E possibly damaging Het
Anxa5 C T 3: 36,503,504 (GRCm39) E317K probably benign Het
Atf2 A T 2: 73,675,844 (GRCm39) M169K possibly damaging Het
Bicc1 C A 10: 70,779,190 (GRCm39) probably benign Het
Bicra A G 7: 15,721,840 (GRCm39) M559T probably benign Het
Bltp3a T C 17: 28,113,563 (GRCm39) I1245T probably benign Het
Bltp3b A T 10: 89,641,055 (GRCm39) Q742L probably benign Het
Cacna1e G A 1: 154,369,155 (GRCm39) A294V probably damaging Het
Cacna1h G A 17: 25,604,723 (GRCm39) P1197S possibly damaging Het
Cmya5 G A 13: 93,227,505 (GRCm39) Q2528* probably null Het
Csgalnact1 C A 8: 68,854,144 (GRCm39) G219V probably damaging Het
Cts8 T C 13: 61,398,784 (GRCm39) T241A probably benign Het
Cubn T C 2: 13,330,037 (GRCm39) I2615V possibly damaging Het
Cxcl12 A G 6: 117,150,546 (GRCm39) probably benign Het
Fig4 T C 10: 41,140,000 (GRCm39) D307G probably damaging Het
Flt1 T C 5: 147,525,412 (GRCm39) I909V probably damaging Het
Foxk1 T A 5: 142,439,340 (GRCm39) S427T probably damaging Het
Gosr1 G A 11: 76,641,688 (GRCm39) T130M probably benign Het
Grik1 G T 16: 87,806,649 (GRCm39) probably null Het
Hipk1 C T 3: 103,685,333 (GRCm39) S94N possibly damaging Het
Ints7 T C 1: 191,318,704 (GRCm39) L147P probably damaging Het
Nsd3 A G 8: 26,156,086 (GRCm39) D551G probably damaging Het
Or5p81 A T 7: 108,267,093 (GRCm39) I157F probably benign Het
Prrc2c T C 1: 162,535,516 (GRCm39) probably benign Het
Ren1 A T 1: 133,286,207 (GRCm39) N250I possibly damaging Het
Ripply2 A C 9: 86,898,009 (GRCm39) probably benign Het
Ryr1 G T 7: 28,768,975 (GRCm39) probably benign Het
Smad3 T A 9: 63,575,064 (GRCm39) K51M probably damaging Het
Snapc1 C A 12: 74,011,370 (GRCm39) probably benign Het
Srfbp1 T G 18: 52,608,726 (GRCm39) V42G probably damaging Het
Srrm1 G A 4: 135,052,415 (GRCm39) P658L unknown Het
Tab1 T C 15: 80,033,031 (GRCm39) V105A probably benign Het
Tat T C 8: 110,723,481 (GRCm39) V323A probably damaging Het
Tdo2 T C 3: 81,875,462 (GRCm39) N164S probably benign Het
Tefm T A 11: 80,027,722 (GRCm39) L345F probably damaging Het
Tmem145 C A 7: 25,014,150 (GRCm39) N407K probably damaging Het
Vmn2r116 A G 17: 23,607,767 (GRCm39) N445S probably damaging Het
Vmn2r20 A G 6: 123,362,585 (GRCm39) M733T probably benign Het
Vmn2r93 G A 17: 18,533,526 (GRCm39) V477M possibly damaging Het
Zdhhc4 A G 5: 143,306,146 (GRCm39) F194S probably damaging Het
Zfp738 A T 13: 67,821,771 (GRCm39) S25T probably damaging Het
Other mutations in Or11g25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01773:Or11g25 APN 14 50,723,230 (GRCm39) missense probably damaging 0.98
IGL01796:Or11g25 APN 14 50,722,998 (GRCm39) missense probably benign 0.28
IGL01916:Or11g25 APN 14 50,722,950 (GRCm39) missense probably benign 0.01
IGL02874:Or11g25 APN 14 50,723,686 (GRCm39) missense possibly damaging 0.57
IGL02898:Or11g25 APN 14 50,723,643 (GRCm39) missense probably damaging 1.00
PIT4515001:Or11g25 UTSW 14 50,723,536 (GRCm39) missense probably benign 0.03
R0085:Or11g25 UTSW 14 50,723,791 (GRCm39) missense probably benign 0.16
R1777:Or11g25 UTSW 14 50,723,757 (GRCm39) missense probably benign 0.08
R1850:Or11g25 UTSW 14 50,723,055 (GRCm39) missense probably benign
R2270:Or11g25 UTSW 14 50,723,494 (GRCm39) missense probably damaging 1.00
R2338:Or11g25 UTSW 14 50,723,097 (GRCm39) missense possibly damaging 0.47
R2971:Or11g25 UTSW 14 50,723,065 (GRCm39) missense probably damaging 0.99
R4594:Or11g25 UTSW 14 50,723,619 (GRCm39) missense probably benign 0.00
R5383:Or11g25 UTSW 14 50,723,509 (GRCm39) nonsense probably null
R5708:Or11g25 UTSW 14 50,723,452 (GRCm39) missense probably damaging 1.00
R6038:Or11g25 UTSW 14 50,723,677 (GRCm39) missense probably damaging 1.00
R6038:Or11g25 UTSW 14 50,723,677 (GRCm39) missense probably damaging 1.00
R7116:Or11g25 UTSW 14 50,723,025 (GRCm39) missense probably benign 0.00
R7702:Or11g25 UTSW 14 50,723,751 (GRCm39) missense possibly damaging 0.79
R8169:Or11g25 UTSW 14 50,723,692 (GRCm39) missense probably benign 0.13
R9040:Or11g25 UTSW 14 50,722,995 (GRCm39) missense probably benign 0.00
R9139:Or11g25 UTSW 14 50,723,707 (GRCm39) missense probably damaging 0.98
Posted On 2015-04-16