Incidental Mutation 'R0369:Tmco5'
ID 30358
Institutional Source Beutler Lab
Gene Symbol Tmco5
Ensembl Gene ENSMUSG00000027355
Gene Name transmembrane and coiled-coil domains 5
Synonyms 1700095F04Rik
MMRRC Submission 038575-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0369 (G1)
Quality Score 186
Status Not validated
Chromosome 2
Chromosomal Location 116709172-116722975 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to G at 116711269 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000122739 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028834] [ENSMUST00000123598] [ENSMUST00000155470]
AlphaFold Q9D9D5
Predicted Effect probably null
Transcript: ENSMUST00000028834
SMART Domains Protein: ENSMUSP00000028834
Gene: ENSMUSG00000027355

DomainStartEndE-ValueType
Pfam:TMCO5 28 302 6.6e-114 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000123598
SMART Domains Protein: ENSMUSP00000115690
Gene: ENSMUSG00000027355

DomainStartEndE-ValueType
Pfam:TMCO5 27 250 3e-79 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151391
Predicted Effect probably null
Transcript: ENSMUST00000155470
SMART Domains Protein: ENSMUSP00000122739
Gene: ENSMUSG00000027355

DomainStartEndE-ValueType
Pfam:TMCO5 27 164 1.8e-47 PFAM
Pfam:TMCO5 161 226 1.5e-14 PFAM
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 97.9%
  • 10x: 94.8%
  • 20x: 87.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921528I07Rik G A 9: 114,129,077 (GRCm39) noncoding transcript Het
Aadacl2 T A 3: 59,932,143 (GRCm39) Y219* probably null Het
Adamts13 C A 2: 26,895,198 (GRCm39) D1096E probably benign Het
Adamts16 T G 13: 70,927,671 (GRCm39) K523Q possibly damaging Het
Adcy2 A G 13: 68,820,019 (GRCm39) F740S probably benign Het
Carmil1 T A 13: 24,266,003 (GRCm39) N253I probably damaging Het
Ccdc97 T C 7: 25,413,833 (GRCm39) T283A probably damaging Het
Cmpk2 G T 12: 26,527,150 (GRCm39) E380* probably null Het
Csmd3 A G 15: 47,833,543 (GRCm39) I911T probably damaging Het
Cyp2c39 T C 19: 39,502,079 (GRCm39) L156P probably damaging Het
D7Ertd443e T C 7: 133,899,866 (GRCm39) I499V possibly damaging Het
Dhx58 A C 11: 100,592,374 (GRCm39) probably null Het
Dip2a C T 10: 76,134,621 (GRCm39) G390S probably damaging Het
Dusp10 A G 1: 183,801,253 (GRCm39) D340G probably damaging Het
Epha1 A T 6: 42,342,407 (GRCm39) C314S probably damaging Het
Exph5 A T 9: 53,284,602 (GRCm39) H561L probably benign Het
Fbxw26 A G 9: 109,552,780 (GRCm39) probably null Het
Foxc1 A C 13: 31,991,495 (GRCm39) N102T probably damaging Het
Fsip2 T C 2: 82,814,908 (GRCm39) I3547T probably benign Het
Gm5464 G T 14: 67,106,774 (GRCm39) probably benign Het
Gnptab C T 10: 88,269,456 (GRCm39) R720C possibly damaging Het
Greb1l T C 18: 10,469,375 (GRCm39) V130A possibly damaging Het
Hmg20a A T 9: 56,394,934 (GRCm39) D216V probably damaging Het
Hnrnpul2 C A 19: 8,801,777 (GRCm39) D328E probably damaging Het
Hsh2d G A 8: 72,954,304 (GRCm39) D229N probably benign Het
Ift172 T C 5: 31,410,985 (GRCm39) Y1691C probably damaging Het
Kremen2 T C 17: 23,961,784 (GRCm39) D241G probably benign Het
Meis2 T C 2: 115,893,897 (GRCm39) D5G possibly damaging Het
Mrps5 G A 2: 127,433,749 (GRCm39) R46K probably benign Het
Myh14 C T 7: 44,310,374 (GRCm39) V170M probably damaging Het
Nexn T C 3: 151,953,894 (GRCm39) N123D probably benign Het
Or11g26 T A 14: 50,753,282 (GRCm39) M207K probably benign Het
Or4d11 A T 19: 12,013,765 (GRCm39) S114T probably benign Het
Or51l14 T A 7: 103,101,423 (GRCm39) I293N probably damaging Het
Pacs1 C T 19: 5,191,726 (GRCm39) V704M probably damaging Het
Papolg A G 11: 23,822,425 (GRCm39) probably null Het
Pdlim3 T C 8: 46,370,543 (GRCm39) V281A probably benign Het
Plpp4 T G 7: 128,925,190 (GRCm39) F142V probably damaging Het
Prb1a G A 6: 132,184,620 (GRCm39) Q338* probably null Het
Psg26 G T 7: 18,216,481 (GRCm39) Y119* probably null Het
Ptger4 A G 15: 5,272,491 (GRCm39) C68R probably benign Het
Ptpre T A 7: 135,272,444 (GRCm39) I399N probably damaging Het
Ripply2 A G 9: 86,898,372 (GRCm39) Y72C probably damaging Het
Rp1l1 T A 14: 64,266,837 (GRCm39) S808T possibly damaging Het
Scn5a G A 9: 119,362,838 (GRCm39) T594I probably damaging Het
Sf3b1 T C 1: 55,037,267 (GRCm39) D883G probably benign Het
Skint5 A T 4: 113,369,220 (GRCm39) probably null Het
Terf1 A G 1: 15,889,207 (GRCm39) H212R probably damaging Het
Tnfaip3 A T 10: 18,882,660 (GRCm39) Y252* probably null Het
Tnrc6a T A 7: 122,770,083 (GRCm39) N624K probably damaging Het
Top3a C A 11: 60,633,615 (GRCm39) R827L probably damaging Het
Unc79 G A 12: 103,055,031 (GRCm39) probably null Het
Usp20 T C 2: 30,901,116 (GRCm39) S422P probably benign Het
Utrn T C 10: 12,509,766 (GRCm39) E2402G probably benign Het
Wdr3 G A 3: 100,063,734 (GRCm39) Q181* probably null Het
Zfp536 T C 7: 37,267,373 (GRCm39) E681G probably damaging Het
Zfp91 C T 19: 12,747,438 (GRCm39) V562I possibly damaging Het
Zfp942 A T 17: 22,148,017 (GRCm39) I204N probably benign Het
Other mutations in Tmco5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01787:Tmco5 APN 2 116,717,781 (GRCm39) missense probably damaging 1.00
IGL03302:Tmco5 APN 2 116,722,760 (GRCm39) missense probably damaging 0.97
R0054:Tmco5 UTSW 2 116,717,768 (GRCm39) missense probably damaging 0.98
R0054:Tmco5 UTSW 2 116,717,768 (GRCm39) missense probably damaging 0.98
R0485:Tmco5 UTSW 2 116,720,588 (GRCm39) missense probably benign 0.15
R0973:Tmco5 UTSW 2 116,713,699 (GRCm39) missense probably benign 0.04
R0973:Tmco5 UTSW 2 116,713,699 (GRCm39) missense probably benign 0.04
R0974:Tmco5 UTSW 2 116,713,699 (GRCm39) missense probably benign 0.04
R1622:Tmco5 UTSW 2 116,710,796 (GRCm39) missense probably benign 0.28
R1838:Tmco5 UTSW 2 116,711,360 (GRCm39) missense probably damaging 1.00
R2060:Tmco5 UTSW 2 116,722,736 (GRCm39) missense probably damaging 1.00
R3761:Tmco5 UTSW 2 116,717,787 (GRCm39) splice site probably null
R4514:Tmco5 UTSW 2 116,710,795 (GRCm39) missense probably damaging 1.00
R4911:Tmco5 UTSW 2 116,722,689 (GRCm39) missense possibly damaging 0.92
R7373:Tmco5 UTSW 2 116,717,226 (GRCm39) missense probably benign 0.09
R7682:Tmco5 UTSW 2 116,716,752 (GRCm39) missense probably benign 0.35
R7752:Tmco5 UTSW 2 116,722,743 (GRCm39) missense probably damaging 0.99
R8342:Tmco5 UTSW 2 116,710,734 (GRCm39) missense probably damaging 1.00
R9289:Tmco5 UTSW 2 116,710,745 (GRCm39) missense probably benign 0.20
R9568:Tmco5 UTSW 2 116,710,730 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTTCATGATGGAAGTTCCCAGCCAG -3'
(R):5'- ACAATGAAGGCTACGGAGTCGC -3'

Sequencing Primer
(F):5'- AGGTCACCTTGAGTTAACCACTG -3'
(R):5'- CGGAGTCGCTTCCCTAGTTG -3'
Posted On 2013-04-24