Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02689:Anapc11'

303674

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Anapc11

Ensembl Gene

ENSMUSG00000025135

Gene Name

anaphase promoting complex subunit 11

Synonyms

1110011I19Rik

Accession Numbers

Essential gene?

Probably essential (E-score: 0.871) question?

Stock #

IGL02689

Quality Score

Status

Chromosome

Chromosomal Location

120489247-120499024 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 120490168 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 28 (M28K)

Ref Sequence

ENSEMBL: ENSMUSP00000097714 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000026125] [ENSMUST00000026128] [ENSMUST00000093140]

AlphaFold

Q9CPX9

Predicted Effect

probably benign
Transcript: ENSMUST00000026125

SMART Domains

Protein: ENSMUSP00000026125
Gene: ENSMUSG00000025134

Domain	Start	End	E-Value	Type
low complexity region	16	53	N/A	INTRINSIC
low complexity region	56	75	N/A	INTRINSIC
low complexity region	94	105	N/A	INTRINSIC
RRM	106	178	7.64e-20	SMART
FoP_duplication	187	255	1.33e-12	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000026128
AA Change: M28K

PolyPhen 2 Score 0.059 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000026128
Gene: ENSMUSG00000025135
AA Change: M28K

Domain	Start	End	E-Value	Type
RING	23	76	4.48e-1	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000093140
AA Change: M28K

PolyPhen 2 Score 0.059 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000097714
Gene: ENSMUSG00000025135
AA Change: M28K

Domain	Start	End	E-Value	Type
RING	23	76	4.48e-1	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000129263

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000148114

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000155325

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000156685

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acer2	G	T	4: 86,835,692 (GRCm39)	A235S	probably benign	Het
Add2	A	G	6: 86,084,388 (GRCm39)	I479V	possibly damaging	Het
Anapc15-ps	T	C	10: 95,508,993 (GRCm39)	S87G	probably benign	Het
Atraid	T	C	5: 31,209,826 (GRCm39)	L46P	probably damaging	Het
Ccdc80	T	A	16: 44,916,772 (GRCm39)	Y509*	probably null	Het
Cdc45	C	T	16: 18,617,479 (GRCm39)	M200I	probably benign	Het
Cecr2	T	A	6: 120,739,128 (GRCm39)	L1257Q	probably damaging	Het
Csn1s2b	A	G	5: 87,957,780 (GRCm39)	I5V	probably benign	Het
Dhps	T	C	8: 85,800,379 (GRCm39)	Y221H	possibly damaging	Het
Dmxl1	T	C	18: 49,997,962 (GRCm39)	S717P	probably damaging	Het
Dppa5a	G	T	9: 78,275,113 (GRCm39)	S63Y	probably damaging	Het
Eif3l	A	T	15: 78,970,719 (GRCm39)	D331V	possibly damaging	Het
Folh1	G	T	7: 86,412,253 (GRCm39)		probably null	Het
Gbp9	G	T	5: 105,253,662 (GRCm39)	Q18K	probably benign	Het
Grm5	A	G	7: 87,251,918 (GRCm39)	K56R	probably damaging	Het
H2-M3	T	A	17: 37,581,432 (GRCm39)	Y31*	probably null	Het
Herc2	T	C	7: 55,815,031 (GRCm39)		probably benign	Het
Itga7	G	T	10: 128,782,687 (GRCm39)	A675S	possibly damaging	Het
Lipo5	G	A	19: 33,445,186 (GRCm39)	H128Y	unknown	Het
Or2bd2	T	C	7: 6,443,574 (GRCm39)	L225P	possibly damaging	Het
Or5b121	A	G	19: 13,507,171 (GRCm39)	I89V	probably benign	Het
Pdk4	C	T	6: 5,487,408 (GRCm39)	V281I	probably benign	Het
Pkn3	G	A	2: 29,970,858 (GRCm39)	G202D	probably damaging	Het
Rcbtb1	A	G	14: 59,462,149 (GRCm39)	N260S	probably damaging	Het
Sipa1l1	T	C	12: 82,487,594 (GRCm39)	F1623L	probably benign	Het
Slfn8	A	G	11: 82,907,934 (GRCm39)	F203S	probably damaging	Het
St6gal2	T	C	17: 55,789,596 (GRCm39)	L210S	probably damaging	Het
Taf5	T	C	19: 47,065,704 (GRCm39)		probably benign	Het
Taok2	A	G	7: 126,475,270 (GRCm39)	F226S	probably damaging	Het
Timm10b	A	G	7: 105,289,839 (GRCm39)		probably benign	Het
Tmx3	A	G	18: 90,555,240 (GRCm39)	N319S	possibly damaging	Het
Trmt1	G	T	8: 85,426,385 (GRCm39)		probably benign	Het

Other mutations in Anapc11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01656:Anapc11	APN	11	120,490,173 (GRCm39)	missense	possibly damaging	0.95
IGL02738:Anapc11	APN	11	120,490,102 (GRCm39)	missense	probably benign	0.07
R0373:Anapc11	UTSW	11	120,496,203 (GRCm39)	missense	probably benign
R0575:Anapc11	UTSW	11	120,490,192 (GRCm39)	missense	probably benign	0.00
R8167:Anapc11	UTSW	11	120,490,112 (GRCm39)	missense	probably benign	0.04
R9480:Anapc11	UTSW	11	120,496,176 (GRCm39)	missense	probably damaging	1.00
R9487:Anapc11	UTSW	11	120,496,250 (GRCm39)	makesense	probably null

Posted On

2015-04-16