Incidental Mutation 'R0369:Plpp4'
ID 30371
Institutional Source Beutler Lab
Gene Symbol Plpp4
Ensembl Gene ENSMUSG00000070366
Gene Name phospholipid phosphatase 4
Synonyms C030048B12Rik, LOC381925, Ppapdc1a
MMRRC Submission 038575-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R0369 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 128858755-128993136 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 128925190 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Valine at position 142 (F142V)
Ref Sequence ENSEMBL: ENSMUSP00000091557 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094018] [ENSMUST00000205630] [ENSMUST00000205896]
AlphaFold Q0VBU9
Predicted Effect probably damaging
Transcript: ENSMUST00000094018
AA Change: F142V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000091557
Gene: ENSMUSG00000070366
AA Change: F142V

DomainStartEndE-ValueType
transmembrane domain 7 24 N/A INTRINSIC
acidPPc 83 222 2.39e-16 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000205630
Predicted Effect probably benign
Transcript: ENSMUST00000205896
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206551
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 97.9%
  • 10x: 94.8%
  • 20x: 87.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921528I07Rik G A 9: 114,129,077 (GRCm39) noncoding transcript Het
Aadacl2 T A 3: 59,932,143 (GRCm39) Y219* probably null Het
Adamts13 C A 2: 26,895,198 (GRCm39) D1096E probably benign Het
Adamts16 T G 13: 70,927,671 (GRCm39) K523Q possibly damaging Het
Adcy2 A G 13: 68,820,019 (GRCm39) F740S probably benign Het
Carmil1 T A 13: 24,266,003 (GRCm39) N253I probably damaging Het
Ccdc97 T C 7: 25,413,833 (GRCm39) T283A probably damaging Het
Cmpk2 G T 12: 26,527,150 (GRCm39) E380* probably null Het
Csmd3 A G 15: 47,833,543 (GRCm39) I911T probably damaging Het
Cyp2c39 T C 19: 39,502,079 (GRCm39) L156P probably damaging Het
D7Ertd443e T C 7: 133,899,866 (GRCm39) I499V possibly damaging Het
Dhx58 A C 11: 100,592,374 (GRCm39) probably null Het
Dip2a C T 10: 76,134,621 (GRCm39) G390S probably damaging Het
Dusp10 A G 1: 183,801,253 (GRCm39) D340G probably damaging Het
Epha1 A T 6: 42,342,407 (GRCm39) C314S probably damaging Het
Exph5 A T 9: 53,284,602 (GRCm39) H561L probably benign Het
Fbxw26 A G 9: 109,552,780 (GRCm39) probably null Het
Foxc1 A C 13: 31,991,495 (GRCm39) N102T probably damaging Het
Fsip2 T C 2: 82,814,908 (GRCm39) I3547T probably benign Het
Gm5464 G T 14: 67,106,774 (GRCm39) probably benign Het
Gnptab C T 10: 88,269,456 (GRCm39) R720C possibly damaging Het
Greb1l T C 18: 10,469,375 (GRCm39) V130A possibly damaging Het
Hmg20a A T 9: 56,394,934 (GRCm39) D216V probably damaging Het
Hnrnpul2 C A 19: 8,801,777 (GRCm39) D328E probably damaging Het
Hsh2d G A 8: 72,954,304 (GRCm39) D229N probably benign Het
Ift172 T C 5: 31,410,985 (GRCm39) Y1691C probably damaging Het
Kremen2 T C 17: 23,961,784 (GRCm39) D241G probably benign Het
Meis2 T C 2: 115,893,897 (GRCm39) D5G possibly damaging Het
Mrps5 G A 2: 127,433,749 (GRCm39) R46K probably benign Het
Myh14 C T 7: 44,310,374 (GRCm39) V170M probably damaging Het
Nexn T C 3: 151,953,894 (GRCm39) N123D probably benign Het
Or11g26 T A 14: 50,753,282 (GRCm39) M207K probably benign Het
Or4d11 A T 19: 12,013,765 (GRCm39) S114T probably benign Het
Or51l14 T A 7: 103,101,423 (GRCm39) I293N probably damaging Het
Pacs1 C T 19: 5,191,726 (GRCm39) V704M probably damaging Het
Papolg A G 11: 23,822,425 (GRCm39) probably null Het
Pdlim3 T C 8: 46,370,543 (GRCm39) V281A probably benign Het
Prb1a G A 6: 132,184,620 (GRCm39) Q338* probably null Het
Psg26 G T 7: 18,216,481 (GRCm39) Y119* probably null Het
Ptger4 A G 15: 5,272,491 (GRCm39) C68R probably benign Het
Ptpre T A 7: 135,272,444 (GRCm39) I399N probably damaging Het
Ripply2 A G 9: 86,898,372 (GRCm39) Y72C probably damaging Het
Rp1l1 T A 14: 64,266,837 (GRCm39) S808T possibly damaging Het
Scn5a G A 9: 119,362,838 (GRCm39) T594I probably damaging Het
Sf3b1 T C 1: 55,037,267 (GRCm39) D883G probably benign Het
Skint5 A T 4: 113,369,220 (GRCm39) probably null Het
Terf1 A G 1: 15,889,207 (GRCm39) H212R probably damaging Het
Tmco5 T G 2: 116,711,269 (GRCm39) probably null Het
Tnfaip3 A T 10: 18,882,660 (GRCm39) Y252* probably null Het
Tnrc6a T A 7: 122,770,083 (GRCm39) N624K probably damaging Het
Top3a C A 11: 60,633,615 (GRCm39) R827L probably damaging Het
Unc79 G A 12: 103,055,031 (GRCm39) probably null Het
Usp20 T C 2: 30,901,116 (GRCm39) S422P probably benign Het
Utrn T C 10: 12,509,766 (GRCm39) E2402G probably benign Het
Wdr3 G A 3: 100,063,734 (GRCm39) Q181* probably null Het
Zfp536 T C 7: 37,267,373 (GRCm39) E681G probably damaging Het
Zfp91 C T 19: 12,747,438 (GRCm39) V562I possibly damaging Het
Zfp942 A T 17: 22,148,017 (GRCm39) I204N probably benign Het
Other mutations in Plpp4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00661:Plpp4 APN 7 128,918,023 (GRCm39) missense probably damaging 1.00
IGL00885:Plpp4 APN 7 128,923,257 (GRCm39) missense probably damaging 1.00
R0016:Plpp4 UTSW 7 128,925,148 (GRCm39) missense probably damaging 1.00
R2149:Plpp4 UTSW 7 128,981,095 (GRCm39) missense probably benign 0.08
R4290:Plpp4 UTSW 7 128,909,356 (GRCm39) missense probably damaging 1.00
R4293:Plpp4 UTSW 7 128,909,356 (GRCm39) missense probably damaging 1.00
R4295:Plpp4 UTSW 7 128,909,356 (GRCm39) missense probably damaging 1.00
R4439:Plpp4 UTSW 7 128,858,813 (GRCm39) start gained probably benign
R5185:Plpp4 UTSW 7 128,918,028 (GRCm39) missense probably damaging 1.00
R6984:Plpp4 UTSW 7 128,992,616 (GRCm39) missense possibly damaging 0.76
R7122:Plpp4 UTSW 7 128,981,207 (GRCm39) missense unknown
R8048:Plpp4 UTSW 7 128,981,201 (GRCm39) missense unknown
R8854:Plpp4 UTSW 7 128,909,362 (GRCm39) nonsense probably null
R8926:Plpp4 UTSW 7 128,923,211 (GRCm39) critical splice acceptor site probably null
R8994:Plpp4 UTSW 7 128,981,157 (GRCm39) missense probably damaging 0.99
R9575:Plpp4 UTSW 7 128,925,211 (GRCm39) missense probably benign 0.06
Z1177:Plpp4 UTSW 7 128,981,201 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TCACTGAGCGTTTCCTCAGCAAC -3'
(R):5'- GCTTTCCTGACTTCCCAAGGATCAC -3'

Sequencing Primer
(F):5'- CTCAGCAACGGTGTCTGAAG -3'
(R):5'- CCAAGGATCACTGTTTTTCTAAACC -3'
Posted On 2013-04-24