Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02691:Vmn1r200'

303725

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r200

Ensembl Gene

ENSMUSG00000101073

Gene Name

vomeronasal 1 receptor 200

Synonyms

V1rh3

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.144) question?

Stock #

IGL02691

Quality Score

Status

Chromosome

Chromosomal Location

22579199-22580137 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 22579428 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Valine at position 68 (D68V)

Ref Sequence

ENSEMBL: ENSMUSP00000153883 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000074324] [ENSMUST00000226157] [ENSMUST00000227326] [ENSMUST00000228726]

AlphaFold

Q8R281

Predicted Effect

probably damaging
Transcript: ENSMUST00000074324
AA Change: D77V

PolyPhen 2 Score 0.960 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000073934
Gene: ENSMUSG00000101073
AA Change: D77V

Domain	Start	End	E-Value	Type
Pfam:V1R	24	307	5.5e-36	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000226157
AA Change: D77V

PolyPhen 2 Score 0.960 (Sensitivity: 0.78; Specificity: 0.95)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000226901

Predicted Effect

probably damaging
Transcript: ENSMUST00000227326
AA Change: D68V

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

Predicted Effect

probably damaging
Transcript: ENSMUST00000228726
AA Change: D77V

PolyPhen 2 Score 0.960 (Sensitivity: 0.78; Specificity: 0.95)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A3galt2	T	C	4: 128,655,457 (GRCm39)	S40P	probably benign	Het
Actl9	G	T	17: 33,652,092 (GRCm39)	V51L	probably damaging	Het
Adcy6	A	T	15: 98,502,185 (GRCm39)	F143Y	probably damaging	Het
Agps	A	T	2: 75,722,204 (GRCm39)	I465F	probably benign	Het
Armc3	T	A	2: 19,240,295 (GRCm39)	F17L	probably damaging	Het
Arsk	A	C	13: 76,223,069 (GRCm39)	M176R	probably damaging	Het
Asz1	G	A	6: 18,076,556 (GRCm39)	T212I	probably damaging	Het
Atp6v1a	A	G	16: 43,931,982 (GRCm39)	I102T	probably damaging	Het
Bpifb6	T	A	2: 153,744,565 (GRCm39)	L2Q	unknown	Het
Cad	A	G	5: 31,212,638 (GRCm39)	Y45C	probably damaging	Het
Ccdc93	A	G	1: 121,414,342 (GRCm39)	D451G	possibly damaging	Het
Cenpj	A	G	14: 56,789,547 (GRCm39)	I834T	probably benign	Het
Cyp2j12	C	T	4: 96,021,231 (GRCm39)		probably null	Het
Dhx8	G	A	11: 101,642,830 (GRCm39)		probably benign	Het
Dync1i1	A	G	6: 5,800,767 (GRCm39)		probably benign	Het
Ell2	T	A	13: 75,904,605 (GRCm39)	D99E	probably damaging	Het
Enpp1	G	T	10: 24,587,790 (GRCm39)	P34T	probably damaging	Het
Fras1	T	A	5: 96,892,564 (GRCm39)	V2888E	possibly damaging	Het
Gmfg	A	G	7: 28,144,295 (GRCm39)	Y40C	probably damaging	Het
Gnal	T	C	18: 67,355,746 (GRCm39)	I369T	probably damaging	Het
Gzmn	T	C	14: 56,404,370 (GRCm39)	T156A	probably benign	Het
H2-DMb2	A	T	17: 34,366,832 (GRCm39)	H88L	probably benign	Het
Ighv7-3	T	C	12: 114,117,016 (GRCm39)	T49A	probably benign	Het
Jakmip3	C	T	7: 138,628,573 (GRCm39)	Q450*	probably null	Het
Klhl20	A	T	1: 160,934,444 (GRCm39)		probably benign	Het
Klk6	A	G	7: 43,477,924 (GRCm39)	T99A	probably benign	Het
Lhx3	A	G	2: 26,093,097 (GRCm39)	C118R	probably damaging	Het
Mapkbp1	T	C	2: 119,803,655 (GRCm39)		probably benign	Het
Naa15	A	G	3: 51,358,747 (GRCm39)	E294G	probably damaging	Het
Nfia	C	T	4: 97,970,045 (GRCm39)	Q373*	probably null	Het
Notch2	C	A	3: 98,042,923 (GRCm39)	Y1429*	probably null	Het
Oc90	A	G	15: 65,754,410 (GRCm39)	S252P	probably damaging	Het
Or56a3b	A	G	7: 104,771,338 (GRCm39)	I225V	probably damaging	Het
Or8k37	T	C	2: 86,469,182 (GRCm39)	Y290C	probably damaging	Het
Pde3b	T	A	7: 114,107,320 (GRCm39)		probably benign	Het
Pdss1	G	A	2: 22,805,253 (GRCm39)	V211I	probably benign	Het
Phactr1	G	T	13: 43,231,213 (GRCm39)	M226I	probably benign	Het
Phf11c	A	G	14: 59,622,236 (GRCm39)	S259P	probably damaging	Het
Phf20l1	A	G	15: 66,476,713 (GRCm39)	N269S	probably damaging	Het
Piezo1	A	G	8: 123,228,688 (GRCm39)	V229A	possibly damaging	Het
Plcb2	T	C	2: 118,541,444 (GRCm39)	K997R	probably benign	Het
Ppm1m	A	T	9: 106,072,568 (GRCm39)	V449E	probably damaging	Het
Ppp1r36dn	T	C	12: 76,498,073 (GRCm39)		noncoding transcript	Het
Rbm12	C	T	2: 155,937,480 (GRCm39)		probably benign	Het
Rgs14	A	G	13: 55,526,836 (GRCm39)		probably null	Het
Rnf123	G	A	9: 107,945,501 (GRCm39)	R390*	probably null	Het
Scamp5	G	T	9: 57,358,660 (GRCm39)	R39S	probably damaging	Het
Slc5a6	C	T	5: 31,199,518 (GRCm39)	V15I	probably damaging	Het
Snx25	A	T	8: 46,558,302 (GRCm39)	V235E	possibly damaging	Het
Tdrd1	G	T	19: 56,832,284 (GRCm39)	E400D	probably damaging	Het
Tln1	T	C	4: 43,539,544 (GRCm39)	R1593G	probably benign	Het
Trdv2-2	T	C	14: 54,199,039 (GRCm39)	F110L	possibly damaging	Het
Ush2a	A	C	1: 188,466,949 (GRCm39)	Y2871S	probably damaging	Het
Vars2	A	C	17: 35,971,140 (GRCm39)	L592R	probably damaging	Het
Vipr2	T	A	12: 116,099,849 (GRCm39)	C239S	probably benign	Het
Vmn1r7	A	T	6: 57,001,373 (GRCm39)	S296T	probably benign	Het
Vmn2r95	T	C	17: 18,672,120 (GRCm39)	I619T	probably benign	Het

Other mutations in Vmn1r200

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00970:Vmn1r200	APN	13	22,579,893 (GRCm39)	missense	probably damaging	1.00
IGL01123:Vmn1r200	APN	13	22,579,571 (GRCm39)	missense	probably benign	0.01
IGL01943:Vmn1r200	APN	13	22,580,097 (GRCm39)	missense	possibly damaging	0.77
R0491:Vmn1r200	UTSW	13	22,579,361 (GRCm39)	missense	probably benign	0.00
R0507:Vmn1r200	UTSW	13	22,579,718 (GRCm39)	missense	probably benign	0.00
R0530:Vmn1r200	UTSW	13	22,579,667 (GRCm39)	missense	probably damaging	1.00
R1033:Vmn1r200	UTSW	13	22,580,060 (GRCm39)	missense	probably damaging	1.00
R1054:Vmn1r200	UTSW	13	22,579,624 (GRCm39)	missense	probably damaging	1.00
R1714:Vmn1r200	UTSW	13	22,579,640 (GRCm39)	missense	possibly damaging	0.96
R1920:Vmn1r200	UTSW	13	22,579,663 (GRCm39)	missense	probably damaging	1.00
R2118:Vmn1r200	UTSW	13	22,579,353 (GRCm39)	missense	probably damaging	1.00
R3784:Vmn1r200	UTSW	13	22,580,025 (GRCm39)	missense	possibly damaging	0.82
R4827:Vmn1r200	UTSW	13	22,579,265 (GRCm39)	missense	probably benign	0.00
R5285:Vmn1r200	UTSW	13	22,579,457 (GRCm39)	missense	possibly damaging	0.51
R5299:Vmn1r200	UTSW	13	22,579,945 (GRCm39)	nonsense	probably null
R6127:Vmn1r200	UTSW	13	22,579,373 (GRCm39)	missense	probably benign	0.07
R7167:Vmn1r200	UTSW	13	22,579,487 (GRCm39)	missense	possibly damaging	0.91
R7854:Vmn1r200	UTSW	13	22,580,009 (GRCm39)	missense	probably benign	0.08
R7977:Vmn1r200	UTSW	13	22,580,025 (GRCm39)	missense	possibly damaging	0.82
R7987:Vmn1r200	UTSW	13	22,580,025 (GRCm39)	missense	possibly damaging	0.82
R8061:Vmn1r200	UTSW	13	22,579,453 (GRCm39)	nonsense	probably null
R8208:Vmn1r200	UTSW	13	22,579,470 (GRCm39)	missense	probably damaging	0.99
R9481:Vmn1r200	UTSW	13	22,579,911 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16