Incidental Mutation 'IGL02692:Zfp386'
ID 303796
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp386
Ensembl Gene ENSMUSG00000042063
Gene Name zinc finger protein 386 (Kruppel-like)
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # IGL02692
Quality Score
Status
Chromosome 12
Chromosomal Location 116011334-116026851 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 116022855 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 156 (E156G)
Ref Sequence ENSEMBL: ENSMUSP00000073241 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073551] [ENSMUST00000183125]
AlphaFold Q1WWJ5
Predicted Effect probably damaging
Transcript: ENSMUST00000073551
AA Change: E156G

PolyPhen 2 Score 0.959 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000073241
Gene: ENSMUSG00000042063
AA Change: E156G

DomainStartEndE-ValueType
KRAB 6 66 1.88e-19 SMART
ZnF_C2H2 379 401 4.72e-2 SMART
ZnF_C2H2 407 429 6.42e-4 SMART
ZnF_C2H2 435 457 5.14e-3 SMART
ZnF_C2H2 463 485 2.09e-3 SMART
ZnF_C2H2 491 513 6.42e-4 SMART
ZnF_C2H2 519 541 4.87e-4 SMART
ZnF_C2H2 547 569 1.28e-3 SMART
ZnF_C2H2 575 597 2.2e-2 SMART
ZnF_C2H2 603 625 5.99e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000182566
Predicted Effect possibly damaging
Transcript: ENSMUST00000183125
AA Change: E191G

PolyPhen 2 Score 0.682 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000138305
Gene: ENSMUSG00000042063
AA Change: E191G

DomainStartEndE-ValueType
KRAB 6 66 1.88e-19 SMART
ZnF_C2H2 379 401 4.72e-2 SMART
ZnF_C2H2 407 429 6.42e-4 SMART
ZnF_C2H2 435 457 5.14e-3 SMART
ZnF_C2H2 463 485 2.09e-3 SMART
ZnF_C2H2 491 513 6.42e-4 SMART
ZnF_C2H2 519 541 4.87e-4 SMART
ZnF_C2H2 547 569 1.28e-3 SMART
ZnF_C2H2 575 597 2.2e-2 SMART
ZnF_C2H2 603 625 5.99e-4 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI

All alleles(4) : Gene trapped(4)

Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017N19Rik A C 10: 100,439,410 (GRCm39) S72R probably benign Het
4930544G11Rik T C 6: 65,929,792 (GRCm39) V9A probably damaging Het
Actl11 A G 9: 107,806,507 (GRCm39) N277D probably benign Het
Adam2 T A 14: 66,311,536 (GRCm39) I57F probably damaging Het
Adgrf1 T C 17: 43,614,669 (GRCm39) F251S probably damaging Het
Anapc15-ps T C 10: 95,509,089 (GRCm39) I64V probably benign Het
Anapc4 T C 5: 53,021,871 (GRCm39) V651A probably damaging Het
Atl2 T C 17: 80,172,482 (GRCm39) N163D probably benign Het
B4galnt3 G A 6: 120,187,272 (GRCm39) R708C probably damaging Het
Capza2 C T 6: 17,654,115 (GRCm39) Q56* probably null Het
Cspg4 T A 9: 56,794,738 (GRCm39) H824Q probably benign Het
Dock7 G A 4: 98,875,623 (GRCm39) P1106S probably damaging Het
Fat4 A G 3: 39,005,235 (GRCm39) Y1878C probably damaging Het
Grk2 A T 19: 4,340,716 (GRCm39) probably benign Het
Lmbrd2 G A 15: 9,149,155 (GRCm39) V13I possibly damaging Het
Loxhd1 G T 18: 77,444,609 (GRCm39) C336F probably damaging Het
Morc1 T A 16: 48,330,596 (GRCm39) F355L probably null Het
Mov10 C A 3: 104,708,119 (GRCm39) E503* probably null Het
Nt5dc3 T A 10: 86,640,642 (GRCm39) probably null Het
Or2w3b A G 11: 58,623,343 (GRCm39) V216A probably benign Het
Phf20 T A 2: 156,140,498 (GRCm39) M724K probably damaging Het
Pla2g2e G T 4: 138,609,870 (GRCm39) probably benign Het
Polq T A 16: 36,880,989 (GRCm39) V772E probably damaging Het
Rhoh A G 5: 66,050,143 (GRCm39) R138G probably benign Het
Rnf123 G A 9: 107,945,501 (GRCm39) R390* probably null Het
Septin7 A G 9: 25,207,786 (GRCm39) probably benign Het
Serpina9 A C 12: 103,974,665 (GRCm39) F163V probably damaging Het
Slc2a13 A T 15: 91,205,861 (GRCm39) F442Y probably benign Het
Slc34a1 G A 13: 55,551,049 (GRCm39) probably benign Het
Slc6a11 T C 6: 114,139,100 (GRCm39) F236S probably damaging Het
Usp1 A G 4: 98,817,197 (GRCm39) K130E probably benign Het
Zfp957 C T 14: 79,450,825 (GRCm39) V325I unknown Het
Other mutations in Zfp386
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01982:Zfp386 APN 12 116,022,788 (GRCm39) missense probably benign
IGL03071:Zfp386 APN 12 116,022,760 (GRCm39) missense probably benign 0.08
F5493:Zfp386 UTSW 12 116,023,922 (GRCm39) missense probably damaging 0.99
R0098:Zfp386 UTSW 12 116,022,834 (GRCm39) nonsense probably null
R0098:Zfp386 UTSW 12 116,022,834 (GRCm39) nonsense probably null
R0372:Zfp386 UTSW 12 116,018,436 (GRCm39) missense possibly damaging 0.71
R0784:Zfp386 UTSW 12 116,023,540 (GRCm39) nonsense probably null
R0866:Zfp386 UTSW 12 116,018,329 (GRCm39) splice site probably benign
R0947:Zfp386 UTSW 12 116,023,398 (GRCm39) missense probably benign 0.11
R1080:Zfp386 UTSW 12 116,023,426 (GRCm39) nonsense probably null
R1517:Zfp386 UTSW 12 116,023,225 (GRCm39) missense possibly damaging 0.67
R1597:Zfp386 UTSW 12 116,023,709 (GRCm39) missense probably damaging 0.99
R1722:Zfp386 UTSW 12 116,023,526 (GRCm39) missense probably damaging 0.99
R2043:Zfp386 UTSW 12 116,022,781 (GRCm39) missense probably benign 0.22
R3741:Zfp386 UTSW 12 116,023,170 (GRCm39) nonsense probably null
R3742:Zfp386 UTSW 12 116,023,170 (GRCm39) nonsense probably null
R3902:Zfp386 UTSW 12 116,023,775 (GRCm39) missense probably damaging 1.00
R5012:Zfp386 UTSW 12 116,022,864 (GRCm39) missense probably benign
R5590:Zfp386 UTSW 12 116,023,347 (GRCm39) missense probably benign 0.41
R5709:Zfp386 UTSW 12 116,023,305 (GRCm39) missense probably benign 0.23
R6156:Zfp386 UTSW 12 116,023,526 (GRCm39) missense probably damaging 0.99
R6184:Zfp386 UTSW 12 116,024,133 (GRCm39) missense possibly damaging 0.64
R6423:Zfp386 UTSW 12 116,023,733 (GRCm39) missense probably damaging 0.96
R8015:Zfp386 UTSW 12 116,023,027 (GRCm39) missense probably damaging 0.96
R8120:Zfp386 UTSW 12 116,018,573 (GRCm39) missense unknown
R8137:Zfp386 UTSW 12 116,023,268 (GRCm39) missense possibly damaging 0.91
R9093:Zfp386 UTSW 12 116,023,878 (GRCm39) nonsense probably null
R9269:Zfp386 UTSW 12 116,023,283 (GRCm39) missense probably benign 0.01
R9320:Zfp386 UTSW 12 116,023,517 (GRCm39) missense probably damaging 1.00
R9331:Zfp386 UTSW 12 116,011,433 (GRCm39) start gained probably benign
R9536:Zfp386 UTSW 12 116,023,686 (GRCm39) missense probably damaging 1.00
R9641:Zfp386 UTSW 12 116,023,330 (GRCm39) missense probably benign 0.03
Z1088:Zfp386 UTSW 12 116,018,393 (GRCm39) missense possibly damaging 0.95
Posted On 2015-04-16