Incidental Mutation 'IGL02693:Zfp334'
ID 303814
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp334
Ensembl Gene ENSMUSG00000017667
Gene Name zinc finger protein 334
Synonyms D2Ertd535e
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02693
Quality Score
Status
Chromosome 2
Chromosomal Location 165216184-165230179 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 165222433 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 537 (T537A)
Ref Sequence ENSEMBL: ENSMUSP00000099373 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103084]
AlphaFold A2A4U6
Predicted Effect possibly damaging
Transcript: ENSMUST00000103084
AA Change: T537A

PolyPhen 2 Score 0.800 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000099373
Gene: ENSMUSG00000017667
AA Change: T537A

DomainStartEndE-ValueType
KRAB 8 68 5.91e-35 SMART
ZnF_C2H2 236 258 5.42e-2 SMART
ZnF_C2H2 264 286 1.2e-3 SMART
ZnF_C2H2 292 314 6.99e-5 SMART
ZnF_C2H2 320 342 1.22e-4 SMART
ZnF_C2H2 348 370 3.39e-3 SMART
ZnF_C2H2 376 398 7.15e-2 SMART
ZnF_C2H2 404 426 1.69e-3 SMART
ZnF_C2H2 432 454 1.92e-2 SMART
ZnF_C2H2 460 482 3.16e-3 SMART
ZnF_C2H2 543 565 1.82e-3 SMART
ZnF_C2H2 571 593 3.69e-4 SMART
ZnF_C2H2 599 621 1.58e-3 SMART
ZnF_C2H2 627 649 1.38e-3 SMART
ZnF_C2H2 655 677 3.89e-3 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the C2H2 zinc finger family. The encoded protein contains a Krueppel-associated box, fourteen C2H2 zinc finger domains, and four C2H2-type/integrase DNA-binding domains. Decreased expression of this gene may be a marker for rheumatoid arthritis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A830018L16Rik A G 1: 11,666,506 (GRCm39) D271G probably damaging Het
Agl A T 3: 116,540,077 (GRCm39) V1478E possibly damaging Het
Ckap5 C T 2: 91,400,556 (GRCm39) P636L probably damaging Het
Cnot1 A G 8: 96,500,113 (GRCm39) V127A probably damaging Het
Cs A G 10: 128,185,678 (GRCm39) probably benign Het
Fbln1 G A 15: 85,113,775 (GRCm39) E170K probably benign Het
Gm5866 A T 5: 52,740,558 (GRCm39) noncoding transcript Het
Lpin3 T C 2: 160,746,975 (GRCm39) V794A probably damaging Het
Ly86 T G 13: 37,559,005 (GRCm39) I68S probably damaging Het
Mrps34 A G 17: 25,114,172 (GRCm39) I11V probably benign Het
Nsmce4a A G 7: 130,144,538 (GRCm39) S122P probably damaging Het
Olfm1 A G 2: 28,102,662 (GRCm39) E112G probably damaging Het
Or5w20 T G 2: 87,726,877 (GRCm39) C111W probably damaging Het
Parp9 A G 16: 35,777,340 (GRCm39) E428G probably benign Het
Phkb T G 8: 86,668,863 (GRCm39) F297V probably damaging Het
Pianp T G 6: 124,978,598 (GRCm39) F268V possibly damaging Het
Polr1a T C 6: 71,940,830 (GRCm39) probably benign Het
Prune2 G A 19: 17,101,855 (GRCm39) G2453E probably benign Het
Ptpn4 T C 1: 119,643,699 (GRCm39) N350D probably damaging Het
Rbm12 C T 2: 155,937,480 (GRCm39) probably benign Het
Rfc4 A G 16: 22,932,960 (GRCm39) S326P probably damaging Het
Rnf123 G A 9: 107,945,501 (GRCm39) R390* probably null Het
Slc35f1 A T 10: 52,809,224 (GRCm39) L70F probably damaging Het
Slc5a7 T C 17: 54,583,947 (GRCm39) T448A probably benign Het
Spata31h1 T C 10: 82,121,092 (GRCm39) I3973V probably benign Het
Spmip9 C A 6: 70,890,488 (GRCm39) R101S possibly damaging Het
Stoml1 T A 9: 58,164,359 (GRCm39) I149N probably damaging Het
Sytl1 A T 4: 132,985,057 (GRCm39) C180S probably benign Het
Traf6 T C 2: 101,518,850 (GRCm39) L113P possibly damaging Het
Trappc9 A G 15: 72,835,542 (GRCm39) probably benign Het
Tubg2 T C 11: 101,051,725 (GRCm39) Y317H probably damaging Het
Other mutations in Zfp334
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02097:Zfp334 APN 2 165,223,643 (GRCm39) nonsense probably null
IGL02185:Zfp334 APN 2 165,228,869 (GRCm39) utr 5 prime probably benign
IGL02415:Zfp334 APN 2 165,223,771 (GRCm39) missense possibly damaging 0.70
ANU23:Zfp334 UTSW 2 165,223,017 (GRCm39) missense probably damaging 1.00
R0040:Zfp334 UTSW 2 165,223,492 (GRCm39) missense probably benign 0.45
R1332:Zfp334 UTSW 2 165,222,776 (GRCm39) missense probably damaging 1.00
R1579:Zfp334 UTSW 2 165,223,719 (GRCm39) missense probably damaging 0.98
R2429:Zfp334 UTSW 2 165,222,432 (GRCm39) missense probably damaging 1.00
R5556:Zfp334 UTSW 2 165,222,504 (GRCm39) missense probably benign
R5579:Zfp334 UTSW 2 165,222,407 (GRCm39) nonsense probably null
R6891:Zfp334 UTSW 2 165,224,644 (GRCm39) missense probably benign
R6918:Zfp334 UTSW 2 165,223,799 (GRCm39) missense possibly damaging 0.46
R8360:Zfp334 UTSW 2 165,225,278 (GRCm39) missense probably benign 0.00
R8998:Zfp334 UTSW 2 165,223,408 (GRCm39) missense possibly damaging 0.80
R9481:Zfp334 UTSW 2 165,222,271 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16