Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02693:Ly86'

303823

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ly86

Ensembl Gene

ENSMUSG00000021423

Gene Name

lymphocyte antigen 86

Synonyms

MD-1, MD1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.054) question?

Stock #

IGL02693

Quality Score

Status

Chromosome

Chromosomal Location

37529276-37603012 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 37559005 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Serine at position 68 (I68S)

Ref Sequence

ENSEMBL: ENSMUSP00000021860 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000021860]

AlphaFold

O88188

PDB Structure

Crystal structure of mouse MD-1 in complex with phosphatidylcholine [X-RAY DIFFRACTION]
Crystal structure of mouse RP105/MD-1 complex [X-RAY DIFFRACTION]

Predicted Effect

probably damaging
Transcript: ENSMUST00000021860
AA Change: I68S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000021860
Gene: ENSMUSG00000021423
AA Change: I68S

Domain	Start	End	E-Value	Type
ML	42	159	4.29e-26	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele display impaired LPS-induced B-cell proliferation and antibody production. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A830018L16Rik	A	G	1: 11,666,506 (GRCm39)	D271G	probably damaging	Het
Agl	A	T	3: 116,540,077 (GRCm39)	V1478E	possibly damaging	Het
Ckap5	C	T	2: 91,400,556 (GRCm39)	P636L	probably damaging	Het
Cnot1	A	G	8: 96,500,113 (GRCm39)	V127A	probably damaging	Het
Cs	A	G	10: 128,185,678 (GRCm39)		probably benign	Het
Fbln1	G	A	15: 85,113,775 (GRCm39)	E170K	probably benign	Het
Gm5866	A	T	5: 52,740,558 (GRCm39)		noncoding transcript	Het
Lpin3	T	C	2: 160,746,975 (GRCm39)	V794A	probably damaging	Het
Mrps34	A	G	17: 25,114,172 (GRCm39)	I11V	probably benign	Het
Nsmce4a	A	G	7: 130,144,538 (GRCm39)	S122P	probably damaging	Het
Olfm1	A	G	2: 28,102,662 (GRCm39)	E112G	probably damaging	Het
Or5w20	T	G	2: 87,726,877 (GRCm39)	C111W	probably damaging	Het
Parp9	A	G	16: 35,777,340 (GRCm39)	E428G	probably benign	Het
Phkb	T	G	8: 86,668,863 (GRCm39)	F297V	probably damaging	Het
Pianp	T	G	6: 124,978,598 (GRCm39)	F268V	possibly damaging	Het
Polr1a	T	C	6: 71,940,830 (GRCm39)		probably benign	Het
Prune2	G	A	19: 17,101,855 (GRCm39)	G2453E	probably benign	Het
Ptpn4	T	C	1: 119,643,699 (GRCm39)	N350D	probably damaging	Het
Rbm12	C	T	2: 155,937,480 (GRCm39)		probably benign	Het
Rfc4	A	G	16: 22,932,960 (GRCm39)	S326P	probably damaging	Het
Rnf123	G	A	9: 107,945,501 (GRCm39)	R390*	probably null	Het
Slc35f1	A	T	10: 52,809,224 (GRCm39)	L70F	probably damaging	Het
Slc5a7	T	C	17: 54,583,947 (GRCm39)	T448A	probably benign	Het
Spata31h1	T	C	10: 82,121,092 (GRCm39)	I3973V	probably benign	Het
Spmip9	C	A	6: 70,890,488 (GRCm39)	R101S	possibly damaging	Het
Stoml1	T	A	9: 58,164,359 (GRCm39)	I149N	probably damaging	Het
Sytl1	A	T	4: 132,985,057 (GRCm39)	C180S	probably benign	Het
Traf6	T	C	2: 101,518,850 (GRCm39)	L113P	possibly damaging	Het
Trappc9	A	G	15: 72,835,542 (GRCm39)		probably benign	Het
Tubg2	T	C	11: 101,051,725 (GRCm39)	Y317H	probably damaging	Het
Zfp334	T	C	2: 165,222,433 (GRCm39)	T537A	possibly damaging	Het

Other mutations in Ly86

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0082:Ly86	UTSW	13	37,602,513 (GRCm39)	critical splice acceptor site	probably null
R4605:Ly86	UTSW	13	37,558,987 (GRCm39)	missense	possibly damaging	0.81
R4642:Ly86	UTSW	13	37,560,877 (GRCm39)	missense	possibly damaging	0.53
R4665:Ly86	UTSW	13	37,559,010 (GRCm39)	missense	probably damaging	0.98
R4904:Ly86	UTSW	13	37,599,496 (GRCm39)	missense	possibly damaging	0.94
R5112:Ly86	UTSW	13	37,559,013 (GRCm39)	missense	probably damaging	1.00
R5300:Ly86	UTSW	13	37,602,588 (GRCm39)	missense	probably benign	0.00
R7145:Ly86	UTSW	13	37,560,986 (GRCm39)	missense	probably damaging	1.00
R7258:Ly86	UTSW	13	37,529,473 (GRCm39)	missense	probably benign
R8524:Ly86	UTSW	13	37,560,869 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16