Incidental Mutation 'IGL02694:Zfp689'
ID 303853
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp689
Ensembl Gene ENSMUSG00000048921
Gene Name zinc finger protein 689
Synonyms 4933416E05Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.161) question?
Stock # IGL02694
Quality Score
Status
Chromosome 7
Chromosomal Location 127041308-127048330 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 127047573 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 94 (D94G)
Ref Sequence ENSEMBL: ENSMUSP00000101906 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053392] [ENSMUST00000106299]
AlphaFold Q8BKK5
Predicted Effect probably benign
Transcript: ENSMUST00000053392
AA Change: D94G

PolyPhen 2 Score 0.248 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000056610
Gene: ENSMUSG00000048921
AA Change: D94G

DomainStartEndE-ValueType
KRAB 29 89 5.03e-29 SMART
low complexity region 121 139 N/A INTRINSIC
ZnF_C2H2 149 169 1.69e2 SMART
ZnF_C2H2 177 199 4.47e-3 SMART
ZnF_C2H2 205 227 3.95e-4 SMART
ZnF_C2H2 233 255 6.78e-3 SMART
ZnF_C2H2 261 283 1.03e-2 SMART
ZnF_C2H2 289 311 1.28e-3 SMART
ZnF_C2H2 317 339 7.9e-4 SMART
ZnF_C2H2 345 367 3.58e-2 SMART
ZnF_C2H2 373 395 3.89e-3 SMART
ZnF_C2H2 401 423 3.58e-2 SMART
ZnF_C2H2 429 451 8.94e-3 SMART
ZnF_C2H2 457 477 9.81e1 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000106299
AA Change: D94G

PolyPhen 2 Score 0.685 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000101906
Gene: ENSMUSG00000048921
AA Change: D94G

DomainStartEndE-ValueType
KRAB 29 89 5.03e-29 SMART
low complexity region 121 139 N/A INTRINSIC
ZnF_C2H2 149 169 1.69e2 SMART
ZnF_C2H2 177 199 4.47e-3 SMART
ZnF_C2H2 205 227 6.88e-4 SMART
ZnF_C2H2 233 255 3.89e-3 SMART
ZnF_C2H2 261 283 3.58e-2 SMART
ZnF_C2H2 289 311 8.94e-3 SMART
ZnF_C2H2 317 337 9.81e1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144796
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147487
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acer3 A G 7: 97,866,084 (GRCm39) I213T probably benign Het
Alox8 T A 11: 69,077,455 (GRCm39) T432S probably damaging Het
Col4a3 T C 1: 82,688,515 (GRCm39) probably benign Het
Cyp2c54 A G 19: 40,035,987 (GRCm39) Y308H possibly damaging Het
Dscam A G 16: 96,394,476 (GRCm39) V1942A probably benign Het
F11 T C 8: 45,705,196 (GRCm39) Y115C probably damaging Het
Fam13b A G 18: 34,584,259 (GRCm39) probably null Het
Gykl1 A G 18: 52,827,257 (GRCm39) H155R probably benign Het
Lmo7 T A 14: 102,124,606 (GRCm39) V355D probably damaging Het
Lrtm2 T A 6: 119,297,846 (GRCm39) D65V possibly damaging Het
Ly6g6f C T 17: 35,300,144 (GRCm39) V235M possibly damaging Het
Mlxipl G A 5: 135,152,872 (GRCm39) probably null Het
Or11j4 A G 14: 50,630,257 (GRCm39) I15V probably benign Het
Or13a20 A G 7: 140,232,093 (GRCm39) N67S probably damaging Het
Or14a256 C T 7: 86,265,518 (GRCm39) V112I probably benign Het
Ppp2r1a A G 17: 21,171,702 (GRCm39) probably benign Het
Psmb2 A G 4: 126,603,351 (GRCm39) N193S probably benign Het
Rassf2 A T 2: 131,851,641 (GRCm39) Y34N possibly damaging Het
Ryr2 A G 13: 11,620,075 (GRCm39) F3841L probably damaging Het
Skint2 A G 4: 112,473,792 (GRCm39) probably benign Het
Spdl1 T C 11: 34,704,448 (GRCm39) I462V probably benign Het
Spopfm1 A G 3: 94,173,459 (GRCm39) M152V probably benign Het
Tlk2 A G 11: 105,112,061 (GRCm39) E138G probably benign Het
Vmn1r89 A G 7: 12,954,056 (GRCm39) E196G probably benign Het
Zfp142 A G 1: 74,609,307 (GRCm39) L1496P probably damaging Het
Zfp944 A G 17: 22,558,899 (GRCm39) V116A probably benign Het
Other mutations in Zfp689
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02814:Zfp689 APN 7 127,044,193 (GRCm39) missense possibly damaging 0.69
BB009:Zfp689 UTSW 7 127,043,523 (GRCm39) missense probably damaging 1.00
BB019:Zfp689 UTSW 7 127,043,523 (GRCm39) missense probably damaging 1.00
R1970:Zfp689 UTSW 7 127,043,959 (GRCm39) missense probably damaging 1.00
R2044:Zfp689 UTSW 7 127,043,998 (GRCm39) missense probably damaging 1.00
R4502:Zfp689 UTSW 7 127,047,925 (GRCm39) missense probably benign 0.03
R5307:Zfp689 UTSW 7 127,047,987 (GRCm39) missense possibly damaging 0.50
R5470:Zfp689 UTSW 7 127,043,425 (GRCm39) missense probably damaging 0.99
R5692:Zfp689 UTSW 7 127,048,071 (GRCm39) start gained probably benign
R6380:Zfp689 UTSW 7 127,043,968 (GRCm39) missense probably damaging 1.00
R6476:Zfp689 UTSW 7 127,043,896 (GRCm39) missense probably damaging 1.00
R7538:Zfp689 UTSW 7 127,044,010 (GRCm39) missense probably damaging 1.00
R7598:Zfp689 UTSW 7 127,047,840 (GRCm39) missense probably benign 0.14
R7932:Zfp689 UTSW 7 127,043,523 (GRCm39) missense probably damaging 1.00
R8221:Zfp689 UTSW 7 127,043,758 (GRCm39) missense probably damaging 1.00
R8688:Zfp689 UTSW 7 127,044,084 (GRCm39) missense probably benign 0.34
R8725:Zfp689 UTSW 7 127,047,940 (GRCm39) missense probably damaging 1.00
R9732:Zfp689 UTSW 7 127,044,283 (GRCm39) nonsense probably null
Posted On 2015-04-16