Incidental Mutation 'IGL02701:Or5m10b'
ID 304129
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or5m10b
Ensembl Gene ENSMUSG00000057761
Gene Name olfactory receptor family 5 subfamily M member 10B
Synonyms GA_x6K02T2Q125-47347069-47348016, Olfr1022, MOR196-1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # IGL02701
Quality Score
Status
Chromosome 2
Chromosomal Location 85698938-85699885 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 85699802 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 289 (I289V)
Ref Sequence ENSEMBL: ENSMUSP00000059312 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054736]
AlphaFold L7MTT3
Predicted Effect probably benign
Transcript: ENSMUST00000054736
AA Change: I289V

PolyPhen 2 Score 0.216 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000059312
Gene: ENSMUSG00000057761
AA Change: I289V

DomainStartEndE-ValueType
Pfam:7tm_4 31 312 4.8e-51 PFAM
Pfam:7TM_GPCR_Srsx 35 304 8e-6 PFAM
Pfam:7tm_1 41 290 9.8e-22 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap21 A G 2: 20,896,902 (GRCm39) C125R probably damaging Het
Blmh A G 11: 76,862,736 (GRCm39) D383G probably benign Het
Brca1 T C 11: 101,416,061 (GRCm39) E691G probably damaging Het
Chrm3 G A 13: 9,928,500 (GRCm39) R179* probably null Het
Cnrip1 A G 11: 17,028,415 (GRCm39) T116A probably benign Het
Csmd2 T C 4: 128,389,934 (GRCm39) V2223A probably benign Het
Dalrd3 T A 9: 108,449,483 (GRCm39) V143D possibly damaging Het
Ddx60 A T 8: 62,432,375 (GRCm39) I886L probably damaging Het
Dennd4a T C 9: 64,804,635 (GRCm39) F1325L possibly damaging Het
Dnmt3l A T 10: 77,890,856 (GRCm39) T253S probably benign Het
Fads2b A G 2: 85,314,513 (GRCm39) L480P probably damaging Het
Ftdc1 G A 16: 58,436,170 (GRCm39) S51L probably benign Het
Gde1 T A 7: 118,297,860 (GRCm39) T9S probably damaging Het
Ggcx T A 6: 72,395,455 (GRCm39) probably benign Het
Hspg2 C T 4: 137,284,485 (GRCm39) A3481V probably damaging Het
Igf1r T C 7: 67,850,997 (GRCm39) Y931H possibly damaging Het
Ighv12-3 A C 12: 114,330,421 (GRCm39) S25A probably damaging Het
Itga5 A C 15: 103,256,193 (GRCm39) C920G probably damaging Het
Kmt5b A G 19: 3,846,681 (GRCm39) D118G probably benign Het
Lrp1b T G 2: 41,136,029 (GRCm39) N1647T possibly damaging Het
Lrrc71 T C 3: 87,649,079 (GRCm39) E363G probably benign Het
Mapk1 A G 16: 16,833,770 (GRCm39) Y41C probably benign Het
Mib1 T C 18: 10,747,357 (GRCm39) V178A probably damaging Het
Or13c7d A G 4: 43,770,366 (GRCm39) I215T probably benign Het
Or5p52 A T 7: 107,502,649 (GRCm39) T242S probably benign Het
Plb1 T C 5: 32,521,541 (GRCm39) V1464A unknown Het
Plekhg5 T C 4: 152,187,479 (GRCm39) S82P probably damaging Het
Plxna4 T C 6: 32,494,494 (GRCm39) T41A probably benign Het
Ppip5k1 A C 2: 121,147,130 (GRCm39) probably null Het
Pttg1ip2 A G 5: 5,516,623 (GRCm39) probably null Het
Rpl14 T C 9: 120,402,639 (GRCm39) probably benign Het
Slc44a2 T C 9: 21,259,247 (GRCm39) F554L probably benign Het
Slco1b2 T A 6: 141,631,271 (GRCm39) V635E probably benign Het
Sv2a T A 3: 96,094,447 (GRCm39) C261S probably damaging Het
Thbs2 T C 17: 14,903,623 (GRCm39) I353V probably benign Het
Tspan4 G A 7: 141,071,941 (GRCm39) V205M probably damaging Het
Vezf1 A T 11: 87,967,047 (GRCm39) R93* probably null Het
Wwox T A 8: 115,433,108 (GRCm39) V258D probably damaging Het
Zmynd12 G T 4: 119,301,952 (GRCm39) probably benign Het
Other mutations in Or5m10b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03265:Or5m10b APN 2 85,699,494 (GRCm39) missense possibly damaging 0.80
PIT4366001:Or5m10b UTSW 2 85,699,226 (GRCm39) missense probably damaging 1.00
R0057:Or5m10b UTSW 2 85,699,597 (GRCm39) nonsense probably null
R0057:Or5m10b UTSW 2 85,699,597 (GRCm39) nonsense probably null
R0554:Or5m10b UTSW 2 85,699,863 (GRCm39) missense probably benign 0.00
R3873:Or5m10b UTSW 2 85,699,306 (GRCm39) nonsense probably null
R3913:Or5m10b UTSW 2 85,699,115 (GRCm39) missense probably damaging 1.00
R4698:Or5m10b UTSW 2 85,699,596 (GRCm39) missense possibly damaging 0.90
R5628:Or5m10b UTSW 2 85,699,149 (GRCm39) missense probably damaging 0.99
R6467:Or5m10b UTSW 2 85,699,714 (GRCm39) nonsense probably null
R6947:Or5m10b UTSW 2 85,699,271 (GRCm39) missense probably benign 0.01
R7092:Or5m10b UTSW 2 85,698,951 (GRCm39) missense probably damaging 1.00
R7351:Or5m10b UTSW 2 85,694,415 (GRCm39) unclassified probably benign
R7574:Or5m10b UTSW 2 85,699,350 (GRCm39) missense probably benign 0.03
R8430:Or5m10b UTSW 2 85,699,526 (GRCm39) missense probably benign 0.00
R8771:Or5m10b UTSW 2 85,699,712 (GRCm39) missense probably damaging 0.99
R8969:Or5m10b UTSW 2 85,699,832 (GRCm39) missense probably benign 0.19
R9101:Or5m10b UTSW 2 85,694,523 (GRCm39) unclassified probably benign
R9630:Or5m10b UTSW 2 85,699,493 (GRCm39) missense probably benign 0.00
R9649:Or5m10b UTSW 2 85,699,819 (GRCm39) missense probably damaging 1.00
R9649:Or5m10b UTSW 2 85,699,278 (GRCm39) missense possibly damaging 0.96
Posted On 2015-04-16