Incidental Mutation 'R0370:Or8k3'
ID 30414
Institutional Source Beutler Lab
Gene Symbol Or8k3
Ensembl Gene ENSMUSG00000075196
Gene Name olfactory receptor family 8 subfamily K member 3
Synonyms GA_x6K02T2Q125-47703682-47702723, MOR188-3, Olfr1047
MMRRC Submission 038576-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.131) question?
Stock # R0370 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 86058354-86059313 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 86059057 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Aspartic acid at position 86 (V86D)
Ref Sequence ENSEMBL: ENSMUSP00000150247 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099901] [ENSMUST00000216056]
AlphaFold Q8VGS0
Predicted Effect probably damaging
Transcript: ENSMUST00000099901
AA Change: V86D

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000097485
Gene: ENSMUSG00000075196
AA Change: V86D

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 5e-51 PFAM
Pfam:7tm_1 41 290 4.8e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216056
AA Change: V86D

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 96.0%
  • 20x: 91.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afg3l1 T C 8: 124,228,293 (GRCm39) S666P probably damaging Het
B3gntl1 A T 11: 121,514,980 (GRCm39) W263R probably damaging Het
Carmil3 A G 14: 55,732,899 (GRCm39) N270S possibly damaging Het
Ctdp1 T C 18: 80,492,569 (GRCm39) E642G probably damaging Het
Cyp2b9 A T 7: 25,909,531 (GRCm39) K433M probably damaging Het
Dcc A G 18: 71,721,056 (GRCm39) V435A possibly damaging Het
Defa26 A T 8: 22,108,875 (GRCm39) M87L probably benign Het
Dnah11 T A 12: 117,958,962 (GRCm39) I2974L probably benign Het
Dnah3 T C 7: 119,685,943 (GRCm39) D131G possibly damaging Het
Dock6 A T 9: 21,725,861 (GRCm39) S1447R probably benign Het
Dtl G T 1: 191,307,462 (GRCm39) N17K probably benign Het
Grid2 A G 6: 64,322,718 (GRCm39) I573V possibly damaging Het
Hoxa9 T C 6: 52,202,684 (GRCm39) E134G possibly damaging Het
Kcnn3 A T 3: 89,574,399 (GRCm39) N637I probably damaging Het
Ktn1 T C 14: 47,901,532 (GRCm39) F97L probably benign Het
Lmbrd2 T C 15: 9,165,939 (GRCm39) I271T probably damaging Het
Lrp6 A C 6: 134,456,729 (GRCm39) I845S probably damaging Het
Med13l T A 5: 118,879,891 (GRCm39) N994K probably benign Het
Mrrf A T 2: 36,067,125 (GRCm39) probably null Het
Mtmr1 G A X: 70,431,837 (GRCm39) V125I probably damaging Het
Nol8 C T 13: 49,815,923 (GRCm39) A677V possibly damaging Het
Or13g1 T A 7: 85,956,057 (GRCm39) N88I probably benign Het
Or51k1 T G 7: 103,661,266 (GRCm39) L214F probably damaging Het
Paxip1 C A 5: 27,965,084 (GRCm39) V659F probably damaging Het
Pclo T C 5: 14,571,104 (GRCm39) V163A probably damaging Het
Pkn3 T A 2: 29,977,184 (GRCm39) H641Q probably damaging Het
Plekhg6 G A 6: 125,347,623 (GRCm39) R444C probably damaging Het
Rfx2 T C 17: 57,106,308 (GRCm39) E175G probably benign Het
Samd9l A C 6: 3,377,264 (GRCm39) probably benign Het
Sec14l5 A T 16: 4,998,570 (GRCm39) T537S probably damaging Het
Serpinb9d A G 13: 33,379,949 (GRCm39) E96G probably damaging Het
Setd4 T C 16: 93,388,006 (GRCm39) E160G probably damaging Het
Sf3b2 C T 19: 5,324,852 (GRCm39) D845N probably damaging Het
Slc16a4 A G 3: 107,208,413 (GRCm39) I308V possibly damaging Het
Slco2b1 T A 7: 99,339,644 (GRCm39) N100Y probably damaging Het
Sptbn1 A T 11: 30,071,545 (GRCm39) S1475R probably benign Het
Tecta T C 9: 42,278,100 (GRCm39) D1136G probably benign Het
Tmem94 G C 11: 115,679,543 (GRCm39) R273S probably damaging Het
Tns3 A G 11: 8,395,730 (GRCm39) S1225P possibly damaging Het
Ugt2b36 A G 5: 87,239,834 (GRCm39) Y184H probably benign Het
Vmn2r59 A T 7: 41,662,150 (GRCm39) M555K probably benign Het
Other mutations in Or8k3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01419:Or8k3 APN 2 86,058,973 (GRCm39) missense possibly damaging 0.78
IGL01470:Or8k3 APN 2 86,058,628 (GRCm39) missense probably benign 0.26
IGL02179:Or8k3 APN 2 86,058,591 (GRCm39) nonsense probably null
IGL02703:Or8k3 APN 2 86,059,323 (GRCm39) utr 5 prime probably benign
R1452:Or8k3 UTSW 2 86,058,799 (GRCm39) missense probably damaging 0.99
R1655:Or8k3 UTSW 2 86,058,424 (GRCm39) missense possibly damaging 0.95
R1866:Or8k3 UTSW 2 86,059,072 (GRCm39) missense probably damaging 0.99
R1970:Or8k3 UTSW 2 86,058,596 (GRCm39) missense probably damaging 1.00
R2385:Or8k3 UTSW 2 86,058,817 (GRCm39) nonsense probably null
R3411:Or8k3 UTSW 2 86,058,986 (GRCm39) missense probably benign 0.08
R3730:Or8k3 UTSW 2 86,059,195 (GRCm39) missense probably benign 0.00
R4655:Or8k3 UTSW 2 86,059,037 (GRCm39) missense probably benign 0.26
R6168:Or8k3 UTSW 2 86,058,938 (GRCm39) missense probably damaging 0.99
R6190:Or8k3 UTSW 2 86,058,578 (GRCm39) missense possibly damaging 0.67
R6492:Or8k3 UTSW 2 86,058,731 (GRCm39) missense possibly damaging 0.91
R7419:Or8k3 UTSW 2 86,058,557 (GRCm39) missense probably damaging 1.00
R8074:Or8k3 UTSW 2 86,058,473 (GRCm39) missense possibly damaging 0.55
R8220:Or8k3 UTSW 2 86,059,309 (GRCm39) missense probably benign 0.00
R8506:Or8k3 UTSW 2 86,058,922 (GRCm39) missense possibly damaging 0.84
R8559:Or8k3 UTSW 2 86,058,988 (GRCm39) missense probably benign 0.00
R8723:Or8k3 UTSW 2 86,058,786 (GRCm39) missense probably damaging 1.00
R9037:Or8k3 UTSW 2 86,059,042 (GRCm39) missense probably benign 0.16
Z1088:Or8k3 UTSW 2 86,058,566 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGCAGAGTTCATCCTCACAATGGC -3'
(R):5'- GGAGACACAACCTTACAGTGGTGAC -3'

Sequencing Primer
(F):5'- TGACTGATGACATTGTAGCCACAG -3'
(R):5'- AATTTGTCCTGATGGGCATCAC -3'
Posted On 2013-04-24