Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02713:Tmem26'

304661

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem26

Ensembl Gene

ENSMUSG00000060044

Gene Name

transmembrane protein 26

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.083) question?

Stock #

IGL02713

Quality Score

Status

Chromosome

Chromosomal Location

68559576-68618485 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 68587125 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Serine at position 191 (F191S)

Ref Sequence

ENSEMBL: ENSMUSP00000079789 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080995] [ENSMUST00000218918] [ENSMUST00000219392]

AlphaFold

Q3UP23

Predicted Effect

probably damaging
Transcript: ENSMUST00000080995
AA Change: F191S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000079789
Gene: ENSMUSG00000060044
AA Change: F191S

Domain	Start	End	E-Value	Type
Pfam:Tmem26	3	304	5.6e-125	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000218918

Predicted Effect

probably benign
Transcript: ENSMUST00000219392

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein containing multiple transmembrane helices. It is a selective surface protein marker of brite/beige adipocytes, which may coexist with classical brown adipocytes in brown adipose tissue. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acan	A	G	7: 78,749,992 (GRCm39)	T1588A	possibly damaging	Het
Apeh	A	T	9: 107,962,871 (GRCm39)	L700Q	probably damaging	Het
Arid1b	T	C	17: 5,393,286 (GRCm39)	I2272T	probably damaging	Het
Best3	T	G	10: 116,860,434 (GRCm39)	F565V	probably benign	Het
Birc6	A	G	17: 74,886,319 (GRCm39)	N521S	probably benign	Het
Cd209f	T	A	8: 4,153,732 (GRCm39)	R191S	probably benign	Het
Clec4e	A	T	6: 123,263,263 (GRCm39)	Y63*	probably null	Het
Cracdl	C	A	1: 37,663,218 (GRCm39)	K893N	possibly damaging	Het
Cyp26c1	C	T	19: 37,681,667 (GRCm39)	T490M	probably damaging	Het
Cyp2b9	T	A	7: 25,872,945 (GRCm39)	H29Q	probably benign	Het
Cyp2d10	A	C	15: 82,290,283 (GRCm39)		probably benign	Het
Dgat1	C	A	15: 76,387,734 (GRCm39)	R291L	probably damaging	Het
Dyrk1a	C	A	16: 94,486,204 (GRCm39)		probably benign	Het
Esp4	T	C	17: 40,913,297 (GRCm39)	F55L	probably benign	Het
Fam227a	G	A	15: 79,520,997 (GRCm39)		probably benign	Het
Ggt1	T	C	10: 75,410,178 (GRCm39)	Y37H	probably damaging	Het
Grsf1	A	T	5: 88,820,589 (GRCm39)	I64K	probably damaging	Het
Itga6	C	T	2: 71,647,057 (GRCm39)	T89I	possibly damaging	Het
Jph2	T	C	2: 163,217,837 (GRCm39)	T280A	probably damaging	Het
Lipm	A	G	19: 34,078,570 (GRCm39)	M1V	probably null	Het
Nbeal1	C	T	1: 60,274,396 (GRCm39)	A513V	possibly damaging	Het
Or10a3	G	A	7: 108,480,060 (GRCm39)	T251I	probably damaging	Het
Or10a48	A	T	7: 108,424,801 (GRCm39)	M135K	probably damaging	Het
Or10q1b	A	T	19: 13,682,553 (GRCm39)	I121F	possibly damaging	Het
Or13a28	A	T	7: 140,217,829 (GRCm39)	I72F	probably damaging	Het
Or5ak25	T	A	2: 85,268,981 (GRCm39)	I174F	probably damaging	Het
Or8b101	C	T	9: 38,020,623 (GRCm39)	P214S	probably damaging	Het
Orc6	A	G	8: 86,034,215 (GRCm39)	E146G	probably benign	Het
Patl2	A	G	2: 121,956,328 (GRCm39)	S179P	probably benign	Het
Pdzd8	C	A	19: 59,333,890 (GRCm39)	G44C	probably damaging	Het
Phox2b	A	G	5: 67,253,938 (GRCm39)		probably benign	Het
Ppp4r3b	T	G	11: 29,138,445 (GRCm39)	H264Q	probably damaging	Het
Ptprk	T	C	10: 28,468,807 (GRCm39)	I1409T	possibly damaging	Het
Pum1	T	A	4: 130,493,323 (GRCm39)	I842N	probably damaging	Het
Rnf123	G	A	9: 107,945,501 (GRCm39)	R390*	probably null	Het
Sgca	T	A	11: 94,862,131 (GRCm39)	N174Y	probably damaging	Het
Slc7a14	A	T	3: 31,311,912 (GRCm39)	L36Q	probably damaging	Het
Srrm1	G	A	4: 135,052,415 (GRCm39)	P658L	unknown	Het
Stard13	G	A	5: 150,965,651 (GRCm39)	Q935*	probably null	Het
Suds3	C	T	5: 117,232,970 (GRCm39)		probably null	Het
Sv2b	A	T	7: 74,773,911 (GRCm39)	L520Q	possibly damaging	Het

Other mutations in Tmem26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00155:Tmem26	APN	10	68,611,184 (GRCm39)	missense	probably damaging	1.00
IGL00471:Tmem26	APN	10	68,614,511 (GRCm39)	missense	possibly damaging	0.78
IGL01301:Tmem26	APN	10	68,614,436 (GRCm39)	missense	probably damaging	1.00
IGL01567:Tmem26	APN	10	68,587,061 (GRCm39)	missense	probably damaging	1.00
IGL02487:Tmem26	APN	10	68,614,563 (GRCm39)	missense	probably benign	0.00
IGL02828:Tmem26	APN	10	68,611,215 (GRCm39)	critical splice donor site	probably null
ANU18:Tmem26	UTSW	10	68,614,436 (GRCm39)	missense	probably damaging	1.00
P0027:Tmem26	UTSW	10	68,614,548 (GRCm39)	missense	probably benign	0.00
R1415:Tmem26	UTSW	10	68,614,491 (GRCm39)	missense	possibly damaging	0.93
R1649:Tmem26	UTSW	10	68,587,103 (GRCm39)	missense	probably damaging	1.00
R3871:Tmem26	UTSW	10	68,614,562 (GRCm39)	missense	probably benign	0.01
R5072:Tmem26	UTSW	10	68,611,178 (GRCm39)	missense	probably damaging	1.00
R5239:Tmem26	UTSW	10	68,587,096 (GRCm39)	missense	probably damaging	0.97
R6053:Tmem26	UTSW	10	68,584,314 (GRCm39)	missense	probably benign	0.00
R6607:Tmem26	UTSW	10	68,614,543 (GRCm39)	missense	probably benign	0.00
R6710:Tmem26	UTSW	10	68,559,884 (GRCm39)	missense	probably damaging	1.00
R7378:Tmem26	UTSW	10	68,559,922 (GRCm39)	critical splice donor site	probably null
R9276:Tmem26	UTSW	10	68,614,488 (GRCm39)	missense	possibly damaging	0.58
R9303:Tmem26	UTSW	10	68,559,816 (GRCm39)	nonsense	probably null
R9305:Tmem26	UTSW	10	68,559,816 (GRCm39)	nonsense	probably null
R9661:Tmem26	UTSW	10	68,559,838 (GRCm39)	missense	probably damaging	1.00
R9716:Tmem26	UTSW	10	68,576,790 (GRCm39)	missense	probably damaging	1.00
T0722:Tmem26	UTSW	10	68,614,548 (GRCm39)	missense	probably benign	0.00
X0003:Tmem26	UTSW	10	68,614,548 (GRCm39)	missense	probably benign	0.00
Z1177:Tmem26	UTSW	10	68,559,793 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16