Incidental Mutation 'IGL02713:Suds3'
ID304673
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Suds3
Ensembl Gene ENSMUSG00000066900
Gene Namesuppressor of defective silencing 3 homolog (S. cerevisiae)
Synonyms
Accession Numbers
Is this an essential gene? Essential (E-score: 1.000) question?
Stock #IGL02713
Quality Score
Status
Chromosome5
Chromosomal Location117091680-117116113 bp(-) (GRCm38)
Type of Mutationsplice site (5 bp from exon)
DNA Base Change (assembly) C to T at 117094905 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000130535 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086471] [ENSMUST00000166397]
Predicted Effect probably null
Transcript: ENSMUST00000086471
SMART Domains Protein: ENSMUSP00000083662
Gene: ENSMUSG00000066900

DomainStartEndE-ValueType
low complexity region 2 37 N/A INTRINSIC
Pfam:Sds3 52 223 3.6e-30 PFAM
low complexity region 225 238 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000166397
SMART Domains Protein: ENSMUSP00000130535
Gene: ENSMUSG00000066900

DomainStartEndE-ValueType
low complexity region 2 37 N/A INTRINSIC
low complexity region 44 56 N/A INTRINSIC
Pfam:Sds3 61 296 4.7e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202684
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202713
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a knock-out allele display early embryonic lethality in the peri-implantation period. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2010300C02Rik C A 1: 37,624,137 K893N possibly damaging Het
Acan A G 7: 79,100,244 T1588A possibly damaging Het
Apeh A T 9: 108,085,672 L700Q probably damaging Het
Arid1b T C 17: 5,343,011 I2272T probably damaging Het
Best3 T G 10: 117,024,529 F565V probably benign Het
Birc6 A G 17: 74,579,324 N521S probably benign Het
Cd209f T A 8: 4,103,732 R191S probably benign Het
Clec4e A T 6: 123,286,304 Y63* probably null Het
Cyp26c1 C T 19: 37,693,219 T490M probably damaging Het
Cyp2b9 T A 7: 26,173,520 H29Q probably benign Het
Cyp2d10 A C 15: 82,406,082 probably benign Het
Dgat1 C A 15: 76,503,534 R291L probably damaging Het
Dyrk1a C A 16: 94,685,345 probably benign Het
Esp4 T C 17: 40,602,406 F55L probably benign Het
Fam227a G A 15: 79,636,796 probably benign Het
Ggt1 T C 10: 75,574,344 Y37H probably damaging Het
Grsf1 A T 5: 88,672,730 I64K probably damaging Het
Itga6 C T 2: 71,816,713 T89I possibly damaging Het
Jph2 T C 2: 163,375,917 T280A probably damaging Het
Lipm A G 19: 34,101,170 M1V probably null Het
Nbeal1 C T 1: 60,235,237 A513V possibly damaging Het
Olfr1491 A T 19: 13,705,189 I121F possibly damaging Het
Olfr514 A T 7: 108,825,594 M135K probably damaging Het
Olfr518 G A 7: 108,880,853 T251I probably damaging Het
Olfr61 A T 7: 140,637,916 I72F probably damaging Het
Olfr888 C T 9: 38,109,327 P214S probably damaging Het
Olfr995 T A 2: 85,438,637 I174F probably damaging Het
Orc6 A G 8: 85,307,586 E146G probably benign Het
Patl2 A G 2: 122,125,847 S179P probably benign Het
Pdzd8 C A 19: 59,345,458 G44C probably damaging Het
Phox2b A G 5: 67,096,595 probably benign Het
Ppp4r3b T G 11: 29,188,445 H264Q probably damaging Het
Ptprk T C 10: 28,592,811 I1409T possibly damaging Het
Pum1 T A 4: 130,766,012 I842N probably damaging Het
Rnf123 G A 9: 108,068,302 R390* probably null Het
Sgca T A 11: 94,971,305 N174Y probably damaging Het
Slc7a14 A T 3: 31,257,763 L36Q probably damaging Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
Stard13 G A 5: 151,042,186 Q935* probably null Het
Sv2b A T 7: 75,124,163 L520Q possibly damaging Het
Tmem26 T C 10: 68,751,295 F191S probably damaging Het
Other mutations in Suds3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02675:Suds3 APN 5 117094905 splice site probably null
R1779:Suds3 UTSW 5 117105244 missense probably benign 0.02
R1986:Suds3 UTSW 5 117108352 missense probably damaging 0.98
R2519:Suds3 UTSW 5 117094953 missense probably damaging 1.00
R5189:Suds3 UTSW 5 117100599 critical splice donor site probably benign
R6213:Suds3 UTSW 5 117106662 missense probably damaging 0.99
Posted On2015-04-16