Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02717:Ifna16'

304802

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ifna16

Ensembl Gene

ENSMUSG00000078355

Gene Name

interferon alpha 16

Synonyms

Gm13280, Ifna6t

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.053) question?

Stock #

IGL02717

Quality Score

Status

Chromosome

Chromosomal Location

88594524-88595093 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 88594777 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 106 (D106G)

Ref Sequence

ENSEMBL: ENSMUSP00000100779 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000105148]

AlphaFold

Q810G1

Predicted Effect

possibly damaging
Transcript: ENSMUST00000105148
AA Change: D106G

PolyPhen 2 Score 0.950 (Sensitivity: 0.79; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000100779
Gene: ENSMUSG00000078355
AA Change: D106G

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
IFabd	58	175	2.69e-66	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abhd4	G	A	14: 54,499,079 (GRCm39)		probably benign	Het
Adgra1	A	T	7: 139,456,094 (GRCm39)	N574I	probably damaging	Het
Agbl2	C	T	2: 90,636,212 (GRCm39)	R583W	probably damaging	Het
Ahnak	A	G	19: 8,979,751 (GRCm39)	D345G	probably benign	Het
Alpk1	T	A	3: 127,474,749 (GRCm39)	H418L	possibly damaging	Het
B4gat1	C	A	19: 5,088,997 (GRCm39)		probably benign	Het
Cdh18	A	T	15: 23,410,801 (GRCm39)	R429*	probably null	Het
Chd1l	T	C	3: 97,491,223 (GRCm39)	N423S	probably damaging	Het
Eef1a2	A	C	2: 180,794,694 (GRCm39)	D168E	probably benign	Het
Eif4g2	A	G	7: 110,677,320 (GRCm39)	I205T	probably benign	Het
Fam227b	T	C	2: 125,845,763 (GRCm39)	I409V	probably null	Het
Fsip2	A	G	2: 82,781,370 (GRCm39)		probably benign	Het
Hadh	T	C	3: 131,043,559 (GRCm39)	T52A	probably benign	Het
Herc1	T	A	9: 66,279,203 (GRCm39)	L37*	probably null	Het
Hoxc4	A	G	15: 102,943,273 (GRCm39)	E42G	possibly damaging	Het
Iqgap3	C	A	3: 88,005,666 (GRCm39)	T498K	probably benign	Het
Kmt2b	G	A	7: 30,282,869 (GRCm39)	T1031M	probably damaging	Het
Or11j4	G	T	14: 50,631,104 (GRCm39)	R297L	probably damaging	Het
Or5g23	A	T	2: 85,439,116 (GRCm39)	I46N	probably damaging	Het
Pilrb1	G	A	5: 137,856,213 (GRCm39)		probably benign	Het
Polq	T	A	16: 36,843,102 (GRCm39)	V212E	probably damaging	Het
Ppp4r3b	A	G	11: 29,123,315 (GRCm39)	T4A	probably benign	Het
Saxo5	C	T	8: 3,536,970 (GRCm39)	R439C	probably damaging	Het
Scn5a	T	A	9: 119,358,076 (GRCm39)	T722S	probably benign	Het
Slc7a4	C	T	16: 17,392,439 (GRCm39)	V332I	possibly damaging	Het
Taar7b	T	C	10: 23,876,258 (GRCm39)	I141T	probably damaging	Het
Wrn	T	C	8: 33,833,601 (GRCm39)	Y104C	probably damaging	Het

Other mutations in Ifna16

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01085:Ifna16	APN	4	88,594,969 (GRCm39)	missense	probably benign
IGL01779:Ifna16	APN	4	88,594,882 (GRCm39)	missense	probably damaging	1.00
IGL03226:Ifna16	APN	4	88,594,741 (GRCm39)	missense	probably benign	0.18
R0040:Ifna16	UTSW	4	88,594,867 (GRCm39)	missense	probably benign	0.35
R0040:Ifna16	UTSW	4	88,594,867 (GRCm39)	missense	probably benign	0.35
R1514:Ifna16	UTSW	4	88,594,979 (GRCm39)	missense	possibly damaging	0.84
R2341:Ifna16	UTSW	4	88,594,565 (GRCm39)	missense	probably damaging	1.00
R4877:Ifna16	UTSW	4	88,594,681 (GRCm39)	missense	probably benign	0.00
R8989:Ifna16	UTSW	4	88,594,912 (GRCm39)	missense	probably damaging	1.00
R9619:Ifna16	UTSW	4	88,594,762 (GRCm39)	missense	probably benign	0.30
R9648:Ifna16	UTSW	4	88,595,060 (GRCm39)	missense	probably benign	0.18
R9688:Ifna16	UTSW	4	88,594,874 (GRCm39)	nonsense	probably null
R9743:Ifna16	UTSW	4	88,594,930 (GRCm39)	missense	probably damaging	1.00
Z1088:Ifna16	UTSW	4	88,594,615 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16