Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02721:Or2y1d'

304986

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or2y1d

Ensembl Gene

ENSMUSG00000107573

Gene Name

olfactory receptor family 2 subfamily Y member 1D

Synonyms

Olfr1389, MOR256-1, GA_x6K02T2QP88-6004387-6003452

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.214) question?

Stock #

IGL02721

Quality Score

Status

Chromosome

Chromosomal Location

49321254-49322326 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 49321468 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Stop codon at position 55 (L55*)

Ref Sequence

ENSEMBL: ENSMUSP00000149222 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000203369] [ENSMUST00000216641] [ENSMUST00000217595]

AlphaFold

Q8VGX0

Predicted Effect

probably null
Transcript: ENSMUST00000203369
AA Change: L55*

SMART Domains

Protein: ENSMUSP00000145461
Gene: ENSMUSG00000107573
AA Change: L55*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	30	306	1.9e-49	PFAM
Pfam:7tm_1	41	289	6.6e-20	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000216641
AA Change: L55*

Predicted Effect

probably null
Transcript: ENSMUST00000217595
AA Change: L55*

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930563M21Rik	T	A	9: 55,888,124 (GRCm39)	I398L	probably benign	Het
4931414P19Rik	A	G	14: 54,823,202 (GRCm39)	S332P	probably damaging	Het
Abca7	T	C	10: 79,849,469 (GRCm39)	S1877P	possibly damaging	Het
Adora2b	G	T	11: 62,155,931 (GRCm39)	A127S	probably damaging	Het
Ahnak	A	G	19: 8,987,071 (GRCm39)	K2785R	probably benign	Het
Anapc2	G	A	2: 25,164,680 (GRCm39)	W21*	probably null	Het
Atp7b	A	G	8: 22,512,493 (GRCm39)	S457P	probably benign	Het
Catsperb	A	G	12: 101,591,556 (GRCm39)	Q1046R	probably null	Het
Comp	A	T	8: 70,828,731 (GRCm39)	N188Y	probably damaging	Het
Crnkl1	A	T	2: 145,765,801 (GRCm39)	I423K	possibly damaging	Het
Crtap	A	T	9: 114,210,707 (GRCm39)	V289E	probably damaging	Het
Ctnna2	T	C	6: 76,958,852 (GRCm39)	N454S	probably damaging	Het
Dnah5	A	T	15: 28,234,389 (GRCm39)		probably null	Het
Dstyk	T	G	1: 132,377,054 (GRCm39)	V220G	probably benign	Het
E230025N22Rik	C	T	18: 36,828,664 (GRCm39)	V5M	probably damaging	Het
Fam111a	T	G	19: 12,564,336 (GRCm39)	N28K	probably benign	Het
Fbxo32	A	G	15: 58,046,358 (GRCm39)	I284T	possibly damaging	Het
Fgb	A	C	3: 82,950,674 (GRCm39)	V360G	possibly damaging	Het
Gm3404	A	T	5: 146,463,738 (GRCm39)	R128*	probably null	Het
Hal	G	T	10: 93,343,360 (GRCm39)	G535*	probably null	Het
Ifna1	A	G	4: 88,768,523 (GRCm39)	D67G	probably benign	Het
Igsf5	T	A	16: 96,192,222 (GRCm39)	S274T	probably damaging	Het
Kdm7a	C	T	6: 39,150,371 (GRCm39)	A134T	possibly damaging	Het
Klhl25	G	T	7: 75,516,648 (GRCm39)	W518L	probably damaging	Het
Map1a	A	T	2: 121,134,518 (GRCm39)	D1778V	probably benign	Het
Nif3l1	A	G	1: 58,497,008 (GRCm39)	D311G	probably damaging	Het
Numa1	A	G	7: 101,649,118 (GRCm39)	T950A	probably benign	Het
Nup54	A	T	5: 92,565,716 (GRCm39)	I406N	possibly damaging	Het
Or10ab5	G	T	7: 108,245,582 (GRCm39)	S67*	probably null	Het
Or6c210	C	T	10: 129,495,824 (GRCm39)	P50S	probably benign	Het
Or6c211	A	T	10: 129,505,992 (GRCm39)	I132N	probably benign	Het
Pcdhb18	T	A	18: 37,623,084 (GRCm39)	M138K	probably benign	Het
Pik3c2g	A	G	6: 139,682,699 (GRCm39)	T27A	probably benign	Het
Plekhb2	A	G	1: 34,908,445 (GRCm39)	N163S	probably benign	Het
Ros1	G	A	10: 52,048,927 (GRCm39)		probably benign	Het
Sh3gl1	A	G	17: 56,324,577 (GRCm39)	L357P	possibly damaging	Het
Skint5	T	A	4: 113,799,746 (GRCm39)	D141V	probably damaging	Het
Slc10a5	A	G	3: 10,399,595 (GRCm39)	V355A	probably benign	Het
Speer1c	T	C	5: 10,293,883 (GRCm39)	K106E	probably damaging	Het
Ssh2	G	T	11: 77,345,551 (GRCm39)	G1179*	probably null	Het
Syde2	A	G	3: 145,707,759 (GRCm39)	N566S	probably damaging	Het
Sytl1	T	C	4: 132,986,189 (GRCm39)	R149G	probably benign	Het
Tnpo2	A	G	8: 85,781,319 (GRCm39)		probably null	Het
Top2b	T	C	14: 16,409,236 (GRCm38)	L793P	probably damaging	Het
U2surp	T	A	9: 95,356,488 (GRCm39)	E789D	probably benign	Het
Vps13c	G	A	9: 67,871,431 (GRCm39)		probably benign	Het
Zbtb34	C	T	2: 33,301,270 (GRCm39)	G424R	probably damaging	Het
Zfhx4	A	G	3: 5,308,367 (GRCm39)	D531G	possibly damaging	Het
Zfp787	C	T	7: 6,135,463 (GRCm39)		probably null	Het

Other mutations in Or2y1d

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02377:Or2y1d	APN	11	49,321,859 (GRCm39)	missense	probably damaging	1.00
IGL02468:Or2y1d	APN	11	49,321,941 (GRCm39)	missense	probably damaging	0.99
IGL02607:Or2y1d	APN	11	49,321,339 (GRCm39)	missense	probably damaging	1.00
IGL02812:Or2y1d	APN	11	49,321,749 (GRCm39)	missense	probably damaging	1.00
IGL03086:Or2y1d	APN	11	49,321,632 (GRCm39)	missense	probably benign	0.03
IGL03047:Or2y1d	UTSW	11	49,321,794 (GRCm39)	missense	probably benign	0.10
PIT4531001:Or2y1d	UTSW	11	49,321,753 (GRCm39)	missense	probably benign	0.01
R0413:Or2y1d	UTSW	11	49,322,212 (GRCm39)	missense	possibly damaging	0.82
R0598:Or2y1d	UTSW	11	49,322,230 (GRCm39)	missense	probably benign	0.00
R0653:Or2y1d	UTSW	11	49,322,078 (GRCm39)	nonsense	probably null
R1654:Or2y1d	UTSW	11	49,321,329 (GRCm39)	missense	probably benign	0.00
R2321:Or2y1d	UTSW	11	49,322,107 (GRCm39)	missense	probably benign	0.00
R4995:Or2y1d	UTSW	11	49,321,482 (GRCm39)	missense	probably damaging	1.00
R5670:Or2y1d	UTSW	11	49,322,035 (GRCm39)	missense	probably damaging	1.00
R6127:Or2y1d	UTSW	11	49,321,633 (GRCm39)	missense	probably damaging	0.97
R6327:Or2y1d	UTSW	11	49,321,828 (GRCm39)	missense	probably damaging	1.00
R6935:Or2y1d	UTSW	11	49,321,825 (GRCm39)	missense	probably damaging	0.97
R7726:Or2y1d	UTSW	11	49,321,727 (GRCm39)	nonsense	probably null
R7923:Or2y1d	UTSW	11	49,321,432 (GRCm39)	missense	probably benign	0.01
R8960:Or2y1d	UTSW	11	49,321,543 (GRCm39)	missense	probably benign	0.19

Posted On

2015-04-16