Incidental Mutation 'IGL02725:Wdcp'
ID 305181
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Wdcp
Ensembl Gene ENSMUSG00000051721
Gene Name WD repeat and coiled coil containing
Synonyms BC068281
Accession Numbers
Essential gene? Possibly essential (E-score: 0.707) question?
Stock # IGL02725
Quality Score
Status
Chromosome 12
Chromosomal Location 4893303-4910043 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 4901206 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Isoleucine at position 354 (N354I)
Ref Sequence ENSEMBL: ENSMUSP00000152571 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053034] [ENSMUST00000085793] [ENSMUST00000220170] [ENSMUST00000220215] [ENSMUST00000223551]
AlphaFold Q6NV72
Predicted Effect probably damaging
Transcript: ENSMUST00000053034
AA Change: N354I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000054102
Gene: ENSMUSG00000051721
AA Change: N354I

DomainStartEndE-ValueType
Pfam:DUF4613 2 610 1.9e-260 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000085793
AA Change: N354I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000082948
Gene: ENSMUSG00000051721
AA Change: N354I

DomainStartEndE-ValueType
Pfam:DUF4613 2 643 2.4e-280 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219069
Predicted Effect probably damaging
Transcript: ENSMUST00000220170
AA Change: N354I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000220215
AA Change: N354I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000223551
AA Change: N354I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4833420G17Rik T C 13: 119,611,445 (GRCm39) I414T possibly damaging Het
Agpat3 A C 10: 78,113,889 (GRCm39) D266E probably benign Het
Alpk3 G T 7: 80,743,358 (GRCm39) Q1058H possibly damaging Het
Atat1 A T 17: 36,220,381 (GRCm39) V37E probably benign Het
Bcl6b A G 11: 70,119,344 (GRCm39) V124A probably damaging Het
Bmt2 T C 6: 13,628,495 (GRCm39) E396G probably damaging Het
Ccdc50 T C 16: 27,255,347 (GRCm39) C237R probably benign Het
Chd9 A G 8: 91,778,312 (GRCm39) I2790M possibly damaging Het
Chkb A G 15: 89,313,340 (GRCm39) L82P probably damaging Het
Cit T C 5: 116,123,532 (GRCm39) Y1458H probably benign Het
Clp1 T A 2: 84,554,208 (GRCm39) K320N probably benign Het
Cry2 T C 2: 92,243,605 (GRCm39) probably benign Het
Cyp20a1 C T 1: 60,405,865 (GRCm39) R220W probably benign Het
Cyp27a1 C T 1: 74,774,862 (GRCm39) P268S probably damaging Het
Cyp2e1 T G 7: 140,343,828 (GRCm39) I22S probably null Het
Defb34 A G 8: 19,173,774 (GRCm39) T3A unknown Het
Dpy19l3 A T 7: 35,411,343 (GRCm39) M422K probably benign Het
Eif4g3 A T 4: 137,897,782 (GRCm39) probably benign Het
Elmod3 A G 6: 72,571,758 (GRCm39) S7P probably damaging Het
Fam151a T G 4: 106,605,211 (GRCm39) S524R probably damaging Het
Gcc1 A T 6: 28,418,458 (GRCm39) V625E probably benign Het
Glmn G A 5: 107,723,155 (GRCm39) P112S possibly damaging Het
Grm5 A C 7: 87,723,873 (GRCm39) D721A probably damaging Het
Hivep3 T C 4: 119,953,019 (GRCm39) V445A possibly damaging Het
Hmcn1 T A 1: 150,480,654 (GRCm39) E4507D possibly damaging Het
Hmcn2 A C 2: 31,295,540 (GRCm39) E2583A probably damaging Het
Ifnb1 T A 4: 88,440,867 (GRCm39) I49F probably benign Het
Ints8 A C 4: 11,239,406 (GRCm39) C306W probably benign Het
Jakmip2 A G 18: 43,695,655 (GRCm39) S540P probably damaging Het
Kctd1 A G 18: 15,102,667 (GRCm39) V838A possibly damaging Het
Klk10 T C 7: 43,431,044 (GRCm39) L29P probably damaging Het
Lyst T A 13: 13,935,412 (GRCm39) I3627K probably damaging Het
Maml3 A G 3: 52,011,195 (GRCm39) S124P probably damaging Het
Nav2 A T 7: 49,214,843 (GRCm39) K1632I probably damaging Het
Or2ab1 T C 11: 58,488,690 (GRCm39) V156A probably benign Het
Pde2a G T 7: 101,156,425 (GRCm39) M616I probably null Het
Pdia2 T C 17: 26,415,506 (GRCm39) D440G probably benign Het
Rab11fip5 A G 6: 85,351,471 (GRCm39) S14P probably damaging Het
Rhpn2 T C 7: 35,079,031 (GRCm39) S383P probably damaging Het
Rnf220 A G 4: 117,129,576 (GRCm39) probably benign Het
Rnf43 A G 11: 87,622,411 (GRCm39) D504G probably damaging Het
Setbp1 A T 18: 78,900,589 (GRCm39) L1026* probably null Het
Slc1a4 A T 11: 20,258,408 (GRCm39) S264T probably damaging Het
Snx19 A G 9: 30,343,556 (GRCm39) N572S possibly damaging Het
Sptan1 T C 2: 29,886,055 (GRCm39) I739T probably damaging Het
Srrm1 G A 4: 135,052,415 (GRCm39) P658L unknown Het
Stat5b A T 11: 100,695,840 (GRCm39) D47E possibly damaging Het
Taar7b A T 10: 23,875,961 (GRCm39) Y42F probably benign Het
Tfdp2 T A 9: 96,169,748 (GRCm39) I33K possibly damaging Het
Tm4sf5 A G 11: 70,401,448 (GRCm39) H149R probably benign Het
Tmco6 A G 18: 36,871,760 (GRCm39) M257V probably benign Het
Tuba8 G T 6: 121,202,916 (GRCm39) G410* probably null Het
Ubd T A 17: 37,504,853 (GRCm39) V4D probably benign Het
Ugt2b34 C T 5: 87,054,284 (GRCm39) V166I probably benign Het
Vmn2r70 C T 7: 85,214,553 (GRCm39) V200I possibly damaging Het
Wipi2 A T 5: 142,652,618 (GRCm39) Y410F possibly damaging Het
Zc3hav1 G T 6: 38,309,127 (GRCm39) P565Q probably damaging Het
Zfp398 T C 6: 47,842,737 (GRCm39) V131A probably benign Het
Zkscan3 T C 13: 21,579,063 (GRCm39) D144G possibly damaging Het
Zpbp T A 11: 11,412,358 (GRCm39) probably benign Het
Other mutations in Wdcp
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00770:Wdcp APN 12 4,905,303 (GRCm39) missense probably damaging 1.00
IGL00774:Wdcp APN 12 4,905,303 (GRCm39) missense probably damaging 1.00
IGL02327:Wdcp APN 12 4,901,115 (GRCm39) missense possibly damaging 0.95
IGL03377:Wdcp APN 12 4,900,691 (GRCm39) nonsense probably null
IGL03381:Wdcp APN 12 4,901,926 (GRCm39) missense probably damaging 1.00
R0152:Wdcp UTSW 12 4,901,583 (GRCm39) missense probably benign 0.06
R0317:Wdcp UTSW 12 4,901,583 (GRCm39) missense probably benign 0.06
R1077:Wdcp UTSW 12 4,900,685 (GRCm39) missense probably damaging 1.00
R1136:Wdcp UTSW 12 4,901,655 (GRCm39) missense possibly damaging 0.78
R1571:Wdcp UTSW 12 4,901,924 (GRCm39) nonsense probably null
R1653:Wdcp UTSW 12 4,901,815 (GRCm39) missense probably damaging 1.00
R1848:Wdcp UTSW 12 4,900,245 (GRCm39) missense possibly damaging 0.86
R4091:Wdcp UTSW 12 4,905,279 (GRCm39) missense probably null 0.00
R5126:Wdcp UTSW 12 4,900,617 (GRCm39) missense probably damaging 0.98
R6148:Wdcp UTSW 12 4,900,621 (GRCm39) missense possibly damaging 0.74
R6529:Wdcp UTSW 12 4,901,143 (GRCm39) missense probably damaging 1.00
R6800:Wdcp UTSW 12 4,901,358 (GRCm39) missense probably damaging 1.00
R7432:Wdcp UTSW 12 4,900,246 (GRCm39) missense probably damaging 1.00
R7821:Wdcp UTSW 12 4,907,975 (GRCm39) missense probably benign 0.07
R8182:Wdcp UTSW 12 4,901,850 (GRCm39) missense probably damaging 1.00
R8553:Wdcp UTSW 12 4,902,024 (GRCm39) intron probably benign
R8845:Wdcp UTSW 12 4,901,439 (GRCm39) missense probably benign 0.26
R9134:Wdcp UTSW 12 4,901,533 (GRCm39) nonsense probably null
R9609:Wdcp UTSW 12 4,900,258 (GRCm39) missense probably damaging 0.98
U24488:Wdcp UTSW 12 4,900,405 (GRCm39) missense probably damaging 1.00
X0026:Wdcp UTSW 12 4,901,077 (GRCm39) nonsense probably null
Z1088:Wdcp UTSW 12 4,900,825 (GRCm39) missense probably damaging 1.00
Z1176:Wdcp UTSW 12 4,901,785 (GRCm39) missense possibly damaging 0.95
Posted On 2015-04-16