Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02726:Dnajc22'

305204

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dnajc22

Ensembl Gene

ENSMUSG00000038009

Gene Name

DnaJ heat shock protein family (Hsp40) member C22

Synonyms

2810451A06Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.071) question?

Stock #

IGL02726

Quality Score

Status

Chromosome

Chromosomal Location

98991102-99002618 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 98998881 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Leucine at position 22 (H22L)

Ref Sequence

ENSEMBL: ENSMUSP00000055482 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000061295]

AlphaFold

Q8CHS2

Predicted Effect

probably damaging
Transcript: ENSMUST00000061295
AA Change: H22L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000055482
Gene: ENSMUSG00000038009
AA Change: H22L

Domain	Start	End	E-Value	Type
Pfam:TM2	1	50	1e-10	PFAM
transmembrane domain	76	98	N/A	INTRINSIC
transmembrane domain	105	124	N/A	INTRINSIC
transmembrane domain	139	161	N/A	INTRINSIC
transmembrane domain	206	228	N/A	INTRINSIC
DnaJ	276	335	1.09e-19	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000146173

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Anapc1	A	T	2: 128,501,705 (GRCm39)	M779K	probably benign	Het
Art1	G	A	7: 101,759,955 (GRCm39)	V85M	probably damaging	Het
Atad2b	G	T	12: 5,024,003 (GRCm39)	E43*	probably null	Het
Clec4a4	A	T	6: 122,967,338 (GRCm39)	I5F	probably damaging	Het
Cr1l	A	T	1: 194,812,188 (GRCm39)	I45N	probably damaging	Het
Dmbt1	T	A	7: 130,676,140 (GRCm39)		probably benign	Het
Dnajb3	A	T	1: 88,133,372 (GRCm39)	V10E	probably damaging	Het
Dnal4	A	G	15: 79,647,745 (GRCm39)	V40A	probably damaging	Het
Dsg1b	G	A	18: 20,532,542 (GRCm39)	V529I	probably benign	Het
Elp1	T	A	4: 56,767,878 (GRCm39)		probably null	Het
Fam131c	T	A	4: 141,110,113 (GRCm39)	D170E	probably benign	Het
Got1	G	A	19: 43,488,851 (GRCm39)		probably null	Het
Herc1	T	A	9: 66,349,270 (GRCm39)	V2043E	probably benign	Het
Hmcn1	A	T	1: 150,532,445 (GRCm39)	Y3147*	probably null	Het
Ifi44	T	C	3: 151,455,233 (GRCm39)		probably benign	Het
Il1b	A	T	2: 129,209,242 (GRCm39)	D129E	probably damaging	Het
Ino80	A	T	2: 119,272,964 (GRCm39)	I504N	probably damaging	Het
Itpr2	A	G	6: 146,277,419 (GRCm39)	I655T	probably benign	Het
Kcnk4	A	G	19: 6,904,457 (GRCm39)		probably null	Het
Mrgprb2	T	A	7: 48,202,618 (GRCm39)	R36W	probably damaging	Het
Mslnl	T	C	17: 25,963,077 (GRCm39)		probably null	Het
Or10ak14	T	A	4: 118,610,961 (GRCm39)	Y260F	probably benign	Het
Or1e33	T	C	11: 73,738,691 (GRCm39)	S87G	probably benign	Het
Or2ag1b	A	C	7: 106,288,577 (GRCm39)	Y120*	probably null	Het
Or8k16	G	T	2: 85,520,554 (GRCm39)	L260F	possibly damaging	Het
Pcnx4	G	T	12: 72,620,986 (GRCm39)	M935I	probably benign	Het
Pdgfra	C	T	5: 75,355,618 (GRCm39)	Q1043*	probably null	Het
Pf4	T	C	5: 90,920,523 (GRCm39)	V28A	probably benign	Het
Piezo1	A	G	8: 123,213,894 (GRCm39)	L1689P	probably damaging	Het
Ppa2	A	G	3: 133,076,222 (GRCm39)	S284G	possibly damaging	Het
Pramel22	G	T	4: 143,381,955 (GRCm39)	P247H	probably damaging	Het
Psd2	T	C	18: 36,120,355 (GRCm39)		probably null	Het
Rbm25	G	T	12: 83,719,626 (GRCm39)	G549W	probably damaging	Het
Ryr2	T	C	13: 11,753,206 (GRCm39)	D1705G	probably damaging	Het
Shf	A	T	2: 122,189,969 (GRCm39)	D96E	probably damaging	Het
Slc1a1	G	A	19: 28,889,169 (GRCm39)	V481M	probably benign	Het
Slc4a9	T	C	18: 36,672,670 (GRCm39)	V807A	probably benign	Het
Syne2	T	A	12: 76,062,356 (GRCm39)	I4226N	probably damaging	Het
Tex56	A	G	13: 35,136,943 (GRCm39)		probably benign	Het
Tkfc	A	T	19: 10,573,576 (GRCm39)	V254E	possibly damaging	Het
Ubr2	A	C	17: 47,283,847 (GRCm39)	Y601D	probably damaging	Het
Ubr5	A	C	15: 38,000,806 (GRCm39)		probably benign	Het
Vmn1r27	A	T	6: 58,192,854 (GRCm39)	I50K	possibly damaging	Het
Wdr55	A	G	18: 36,896,435 (GRCm39)	E375G	probably benign	Het

Other mutations in Dnajc22

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00091:Dnajc22	APN	15	98,999,059 (GRCm39)	missense	possibly damaging	0.73
IGL00922:Dnajc22	APN	15	98,999,460 (GRCm39)	missense	possibly damaging	0.89
IGL02155:Dnajc22	APN	15	98,998,886 (GRCm39)	missense	probably damaging	1.00
IGL03074:Dnajc22	APN	15	98,999,403 (GRCm39)	missense	probably damaging	1.00
F5770:Dnajc22	UTSW	15	98,999,363 (GRCm39)	missense	probably damaging	0.99
R1138:Dnajc22	UTSW	15	99,002,308 (GRCm39)	small deletion	probably benign
R1628:Dnajc22	UTSW	15	98,998,817 (GRCm39)	start codon destroyed	probably null	1.00
R2018:Dnajc22	UTSW	15	98,999,114 (GRCm39)	missense	probably benign	0.06
R2146:Dnajc22	UTSW	15	99,002,264 (GRCm39)	missense	probably benign	0.04
R4342:Dnajc22	UTSW	15	99,002,345 (GRCm39)	nonsense	probably null
R4950:Dnajc22	UTSW	15	98,999,615 (GRCm39)	missense	probably benign	0.29
R7123:Dnajc22	UTSW	15	98,999,085 (GRCm39)	missense	possibly damaging	0.89
R7173:Dnajc22	UTSW	15	98,999,187 (GRCm39)	missense	probably benign	0.06
R7640:Dnajc22	UTSW	15	98,998,995 (GRCm39)	missense	probably damaging	1.00
R7997:Dnajc22	UTSW	15	98,999,514 (GRCm39)	missense	probably damaging	1.00
R8338:Dnajc22	UTSW	15	98,999,022 (GRCm39)	missense	probably benign	0.00
R8745:Dnajc22	UTSW	15	98,999,345 (GRCm39)	missense	probably benign	0.01
V7580:Dnajc22	UTSW	15	98,999,363 (GRCm39)	missense	probably damaging	0.99
V7581:Dnajc22	UTSW	15	98,999,363 (GRCm39)	missense	probably damaging	0.99
V7582:Dnajc22	UTSW	15	98,999,363 (GRCm39)	missense	probably damaging	0.99
V7583:Dnajc22	UTSW	15	98,999,363 (GRCm39)	missense	probably damaging	0.99

Posted On

2015-04-16