Incidental Mutation 'IGL02727:Dusp11'
ID 305258
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dusp11
Ensembl Gene ENSMUSG00000030002
Gene Name dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
Synonyms 2010300F21Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02727
Quality Score
Status
Chromosome 6
Chromosomal Location 85919250-85938649 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 85938474 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 15 (D15G)
Ref Sequence ENSEMBL: ENSMUSP00000032071 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032071]
AlphaFold Q6NXK5
Predicted Effect probably damaging
Transcript: ENSMUST00000032071
AA Change: D15G

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000032071
Gene: ENSMUSG00000030002
AA Change: D15G

DomainStartEndE-ValueType
low complexity region 6 14 N/A INTRINSIC
Pfam:DSPc 74 203 2.5e-18 PFAM
low complexity region 230 243 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134793
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151394
Predicted Effect probably benign
Transcript: ENSMUST00000201530
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201818
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202379
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq, Sep 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700019A02Rik T C 1: 53,226,724 (GRCm39) T13A probably benign Het
Aldh1l2 T A 10: 83,342,469 (GRCm39) K447I probably damaging Het
Ankrd17 A G 5: 90,392,151 (GRCm39) S1840P possibly damaging Het
Ash1l A G 3: 88,930,344 (GRCm39) I1940M probably benign Het
Bfar T G 16: 13,506,791 (GRCm39) probably null Het
Bicra G T 7: 15,713,390 (GRCm39) H937Q possibly damaging Het
Brip1 A T 11: 86,043,562 (GRCm39) M334K probably benign Het
Camsap2 T G 1: 136,232,050 (GRCm39) M182L probably benign Het
Chd6 A T 2: 160,811,383 (GRCm39) C1407S probably damaging Het
Cmya5 A G 13: 93,234,753 (GRCm39) S112P possibly damaging Het
Csmd1 A T 8: 16,281,341 (GRCm39) V728E probably damaging Het
Cyp2j6 T A 4: 96,434,001 (GRCm39) Q103L probably benign Het
Ddias A T 7: 92,515,830 (GRCm39) I21K probably damaging Het
Derl2 A C 11: 70,904,036 (GRCm39) probably benign Het
Dgka A T 10: 128,558,317 (GRCm39) probably benign Het
Enpp2 T C 15: 54,773,577 (GRCm39) D110G probably damaging Het
Fkbp11 A T 15: 98,622,471 (GRCm39) V134E probably damaging Het
Gm3248 T C 14: 5,945,036 (GRCm38) T49A probably damaging Het
Gm57858 T A 3: 36,087,065 (GRCm39) R176S possibly damaging Het
Irag2 T C 6: 145,120,344 (GRCm39) S520P possibly damaging Het
Luzp2 T C 7: 54,821,939 (GRCm39) probably benign Het
Manea C A 4: 26,328,127 (GRCm39) E305* probably null Het
Manea T A 4: 26,328,126 (GRCm39) E305V probably damaging Het
Megf6 A G 4: 154,337,606 (GRCm39) probably null Het
Mrpl3 G T 9: 104,931,726 (GRCm39) D59Y probably damaging Het
Myh9 T C 15: 77,675,942 (GRCm39) Y248C probably benign Het
Nbeal2 G A 9: 110,468,353 (GRCm39) probably benign Het
Or10a5 G T 7: 106,635,902 (GRCm39) C180F probably damaging Het
Or1f19 T A 16: 3,411,190 (GRCm39) I310K probably benign Het
Or2y1c G T 11: 49,361,893 (GRCm39) G305V probably benign Het
Or8b40 A G 9: 38,027,808 (GRCm39) T239A probably damaging Het
Pax8 C A 2: 24,331,642 (GRCm39) C147F probably damaging Het
Phf12 T C 11: 77,914,493 (GRCm39) V96A possibly damaging Het
Psg18 A T 7: 18,079,875 (GRCm39) I442K probably damaging Het
Pygl T A 12: 70,254,442 (GRCm39) probably null Het
Rassf2 C A 2: 131,846,307 (GRCm39) R150L probably benign Het
Rdh7 A T 10: 127,723,487 (GRCm39) W123R probably damaging Het
Saal1 T C 7: 46,339,223 (GRCm39) probably null Het
Sall1 T C 8: 89,757,383 (GRCm39) D907G probably damaging Het
Spag1 T A 15: 36,234,964 (GRCm39) F876I probably damaging Het
Syncrip G A 9: 88,361,932 (GRCm39) A61V probably damaging Het
Trbv3 A T 6: 41,025,576 (GRCm39) K55N probably benign Het
Vmn1r178 A G 7: 23,593,871 (GRCm39) probably null Het
Vmn2r84 T C 10: 130,229,995 (GRCm39) D39G possibly damaging Het
Other mutations in Dusp11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01107:Dusp11 APN 6 85,929,352 (GRCm39) splice site probably benign
IGL01584:Dusp11 APN 6 85,930,376 (GRCm39) missense probably damaging 1.00
IGL02276:Dusp11 APN 6 85,935,599 (GRCm39) missense probably damaging 1.00
R0372:Dusp11 UTSW 6 85,935,712 (GRCm39) splice site probably benign
R0413:Dusp11 UTSW 6 85,929,352 (GRCm39) splice site probably benign
R1669:Dusp11 UTSW 6 85,927,008 (GRCm39) missense probably benign 0.05
R2115:Dusp11 UTSW 6 85,935,651 (GRCm39) missense probably damaging 1.00
R4610:Dusp11 UTSW 6 85,927,037 (GRCm39) missense probably damaging 1.00
R4678:Dusp11 UTSW 6 85,930,363 (GRCm39) missense probably damaging 0.98
R5288:Dusp11 UTSW 6 85,924,587 (GRCm39) makesense probably null
R5386:Dusp11 UTSW 6 85,924,587 (GRCm39) makesense probably null
R5756:Dusp11 UTSW 6 85,929,339 (GRCm39) missense probably damaging 1.00
R5987:Dusp11 UTSW 6 85,936,215 (GRCm39) nonsense probably null
R6591:Dusp11 UTSW 6 85,938,507 (GRCm39) missense possibly damaging 0.53
R6691:Dusp11 UTSW 6 85,938,507 (GRCm39) missense possibly damaging 0.53
R7684:Dusp11 UTSW 6 85,927,542 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16