Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02731:Vmn1r42'

305437

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r42

Ensembl Gene

ENSMUSG00000068232

Gene Name

vomeronasal 1 receptor 42

Synonyms

V1ra6

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

IGL02731

Quality Score

Status

Chromosome

Chromosomal Location

89821500-89822597 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 89822407 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Arginine at position 54 (K54R)

Ref Sequence

ENSEMBL: ENSMUSP00000154442 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000089419] [ENSMUST00000226436] [ENSMUST00000227279]

AlphaFold

Q8VBS7

Predicted Effect

probably benign
Transcript: ENSMUST00000089419
AA Change: K54R

PolyPhen 2 Score 0.405 (Sensitivity: 0.89; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000086840
Gene: ENSMUSG00000068232
AA Change: K54R

Domain	Start	End	E-Value	Type
Pfam:V1R	54	318	3.6e-132	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000226436
AA Change: K54R

PolyPhen 2 Score 0.405 (Sensitivity: 0.89; Specificity: 0.89)

Predicted Effect

probably benign
Transcript: ENSMUST00000227279
AA Change: K54R

PolyPhen 2 Score 0.405 (Sensitivity: 0.89; Specificity: 0.89)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akap10	A	T	11: 61,784,302 (GRCm39)	D515E	possibly damaging	Het
Ankrd13b	A	T	11: 77,367,045 (GRCm39)	S9R	probably damaging	Het
Ano9	G	A	7: 140,687,117 (GRCm39)	A374V	probably damaging	Het
Cdc45	C	T	16: 18,617,479 (GRCm39)	M200I	probably benign	Het
Cep78	T	A	19: 15,933,670 (GRCm39)	H636L	probably benign	Het
Chd2	A	G	7: 73,143,204 (GRCm39)	V563A	probably damaging	Het
Cndp1	G	T	18: 84,650,083 (GRCm39)	D203E	probably damaging	Het
Col16a1	G	A	4: 129,947,323 (GRCm39)		probably benign	Het
Copa	T	C	1: 171,929,785 (GRCm39)	V284A	possibly damaging	Het
Dlec1	A	G	9: 118,976,188 (GRCm39)	T1656A	probably benign	Het
Dop1a	T	C	9: 86,369,434 (GRCm39)	I89T	probably damaging	Het
Eif2ak4	T	C	2: 118,219,295 (GRCm39)	S36P	probably benign	Het
Ep300	A	T	15: 81,532,615 (GRCm39)	I1618F	unknown	Het
Fan1	G	A	7: 64,022,741 (GRCm39)	L171F	possibly damaging	Het
Fancm	A	G	12: 65,135,079 (GRCm39)	T291A	probably benign	Het
Gm14325	T	C	2: 177,474,779 (GRCm39)	K101R	probably damaging	Het
Hmx3	A	T	7: 131,145,692 (GRCm39)		probably null	Het
Htt	G	T	5: 34,961,137 (GRCm39)	V255L	probably benign	Het
L3mbtl3	C	T	10: 26,220,074 (GRCm39)		probably null	Het
Lmbr1l	A	G	15: 98,815,777 (GRCm39)	L9P	probably damaging	Het
Lyzl6	A	T	11: 103,525,903 (GRCm39)	Y72*	probably null	Het
Mib1	A	G	18: 10,800,115 (GRCm39)	E818G	possibly damaging	Het
Neb	T	C	2: 52,050,715 (GRCm39)	T6405A	probably damaging	Het
Npas3	A	G	12: 54,114,578 (GRCm39)	D482G	probably benign	Het
Nuak2	C	A	1: 132,244,095 (GRCm39)	A43E	probably damaging	Het
Or10ag2	G	A	2: 87,249,051 (GRCm39)	V220I	probably benign	Het
Or4a70	T	C	2: 89,323,801 (GRCm39)	Y285C	probably damaging	Het
Or4f4b	A	T	2: 111,313,873 (GRCm39)	I33L	probably benign	Het
Or5an1	T	C	19: 12,261,206 (GRCm39)	S265P	probably damaging	Het
Pde11a	C	A	2: 75,821,583 (GRCm39)	A899S	probably benign	Het
Ppfibp2	A	T	7: 107,345,629 (GRCm39)	I884F	possibly damaging	Het
Pus7l	A	G	15: 94,421,345 (GRCm39)	V655A	probably benign	Het
Rad51ap2	A	G	12: 11,506,897 (GRCm39)	D273G	probably damaging	Het
Rc3h2	T	C	2: 37,272,823 (GRCm39)	D751G	probably benign	Het
Sdk1	C	T	5: 142,158,299 (GRCm39)	A1863V	probably damaging	Het
Spns3	T	C	11: 72,420,403 (GRCm39)	Y361C	probably damaging	Het
Srp72	T	A	5: 77,142,062 (GRCm39)	I372N	probably damaging	Het
Srrm1	G	A	4: 135,052,415 (GRCm39)	P658L	unknown	Het
Tcf20	A	G	15: 82,737,438 (GRCm39)	S1338P	probably benign	Het
Tcte1	G	A	17: 45,850,812 (GRCm39)	V363I	probably benign	Het
Vps13b	A	G	15: 35,917,274 (GRCm39)	N3706S	probably benign	Het
Vwde	T	C	6: 13,192,613 (GRCm39)	Y430C	probably damaging	Het
Wdr55	A	G	18: 36,896,435 (GRCm39)	E375G	probably benign	Het
Zfp959	G	A	17: 56,202,956 (GRCm39)		probably benign	Het

Other mutations in Vmn1r42

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02055:Vmn1r42	APN	6	89,822,571 (GRCm39)	utr 5 prime	probably benign
IGL02151:Vmn1r42	APN	6	89,822,023 (GRCm39)	missense	possibly damaging	0.90
IGL02158:Vmn1r42	APN	6	89,822,296 (GRCm39)	missense	probably damaging	0.96
IGL02738:Vmn1r42	APN	6	89,821,630 (GRCm39)	missense	possibly damaging	0.69
IGL02817:Vmn1r42	APN	6	89,822,518 (GRCm39)	missense	probably damaging	1.00
volkan	UTSW	6	89,821,949 (GRCm39)	missense	probably benign	0.00
R1131:Vmn1r42	UTSW	6	89,822,551 (GRCm39)	missense	possibly damaging	0.88
R1500:Vmn1r42	UTSW	6	89,822,483 (GRCm39)	missense	probably benign	0.01
R1557:Vmn1r42	UTSW	6	89,821,733 (GRCm39)	missense	possibly damaging	0.66
R1561:Vmn1r42	UTSW	6	89,822,363 (GRCm39)	missense	probably damaging	0.99
R1574:Vmn1r42	UTSW	6	89,822,363 (GRCm39)	missense	probably damaging	0.99
R1574:Vmn1r42	UTSW	6	89,822,059 (GRCm39)	missense	possibly damaging	0.62
R1574:Vmn1r42	UTSW	6	89,822,059 (GRCm39)	missense	possibly damaging	0.62
R1857:Vmn1r42	UTSW	6	89,821,597 (GRCm39)	missense	probably benign	0.28
R1858:Vmn1r42	UTSW	6	89,821,597 (GRCm39)	missense	probably benign	0.28
R1916:Vmn1r42	UTSW	6	89,821,949 (GRCm39)	missense	probably benign	0.00
R2284:Vmn1r42	UTSW	6	89,821,681 (GRCm39)	missense	probably benign	0.26
R2912:Vmn1r42	UTSW	6	89,821,688 (GRCm39)	missense	probably benign
R4541:Vmn1r42	UTSW	6	89,822,533 (GRCm39)	missense	probably benign
R5085:Vmn1r42	UTSW	6	89,821,598 (GRCm39)	missense	probably benign	0.00
R5384:Vmn1r42	UTSW	6	89,822,366 (GRCm39)	missense	probably damaging	1.00
R5616:Vmn1r42	UTSW	6	89,822,084 (GRCm39)	missense	possibly damaging	0.66
R5647:Vmn1r42	UTSW	6	89,822,314 (GRCm39)	missense	probably benign	0.43
R5867:Vmn1r42	UTSW	6	89,821,761 (GRCm39)	nonsense	probably null
R6569:Vmn1r42	UTSW	6	89,822,425 (GRCm39)	missense	probably damaging	1.00
R6852:Vmn1r42	UTSW	6	89,821,769 (GRCm39)	missense	possibly damaging	0.71
R7054:Vmn1r42	UTSW	6	89,822,051 (GRCm39)	missense	possibly damaging	0.90
R7399:Vmn1r42	UTSW	6	89,822,495 (GRCm39)	missense	probably benign	0.27
R7958:Vmn1r42	UTSW	6	89,822,059 (GRCm39)	missense	probably damaging	0.99

Posted On

2015-04-16