Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02732:Mdp1'

305491

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mdp1

Ensembl Gene

ENSMUSG00000002329

Gene Name

magnesium-dependent phosphatase 1

Synonyms

1810034K20Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02732

Quality Score

Status

Chromosome

Chromosomal Location

55895346-55897908 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 55896678 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 128 (I128V)

Ref Sequence

ENSEMBL: ENSMUSP00000002400 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000002400] [ENSMUST00000010520] [ENSMUST00000163750]

AlphaFold

Q9D967

PDB Structure

Magnesium Dependent Phosphatase 1 (MDP-1) [X-RAY DIFFRACTION]
X-ray Crystal Structure of the Hypothetical Phosphotyrosine Phosphatase MDP-1 of the Haloacid Dehalogenase Superfamily [X-RAY DIFFRACTION]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000002400
AA Change: I128V

PolyPhen 2 Score 0.892 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000002400
Gene: ENSMUSG00000002329
AA Change: I128V

Domain	Start	End	E-Value	Type
Pfam:Acid_PPase	3	160	3e-62	PFAM
Pfam:HAD_2	30	141	2.9e-7	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000010520

SMART Domains

Protein: ENSMUSP00000010520
Gene: ENSMUSG00000010376

Domain	Start	End	E-Value	Type
UBQ	1	72	3.94e-26	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000163750

SMART Domains

Protein: ENSMUSP00000130492
Gene: ENSMUSG00000010376

Domain	Start	End	E-Value	Type
UBQ	1	72	3.94e-26	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000226659

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000227157

Predicted Effect

probably benign
Transcript: ENSMUST00000227250

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000227568

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000228414

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000228093

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Apoo-ps	C	A	13: 107,551,123 (GRCm39)		noncoding transcript	Het
Ash1l	T	A	3: 88,873,535 (GRCm39)	V106E	probably damaging	Het
Baz2a	A	G	10: 127,961,044 (GRCm39)	T1618A	possibly damaging	Het
Brca1	A	G	11: 101,383,045 (GRCm39)	S1732P	probably benign	Het
Cdh1	T	A	8: 107,392,955 (GRCm39)	I813N	probably damaging	Het
Cdk5rap2	G	A	4: 70,184,902 (GRCm39)	R1183*	probably null	Het
Cep170	C	T	1: 176,564,440 (GRCm39)	E1479K	probably damaging	Het
Cep68	A	T	11: 20,186,109 (GRCm39)		probably benign	Het
Cog7	C	T	7: 121,522,590 (GRCm39)	V750I	probably benign	Het
Cplane1	A	G	15: 8,209,375 (GRCm39)	T271A	probably benign	Het
Cyb5d1	A	C	11: 69,284,635 (GRCm39)		probably null	Het
Dlgap4	A	G	2: 156,591,243 (GRCm39)	K120E	probably benign	Het
Dmtf1	T	C	5: 9,186,098 (GRCm39)	I75V	possibly damaging	Het
Fnip2	T	C	3: 79,373,004 (GRCm39)	T995A	probably damaging	Het
Hecw2	G	A	1: 53,965,847 (GRCm39)		probably benign	Het
Il17rd	T	A	14: 26,809,376 (GRCm39)	F111I	probably damaging	Het
Itgb8	A	C	12: 119,127,088 (GRCm39)	M722R	probably benign	Het
Maip1	A	G	1: 57,449,114 (GRCm39)	D165G	probably damaging	Het
Mcm6	A	T	1: 128,287,227 (GRCm39)	C26S	probably benign	Het
Myof	A	T	19: 37,966,164 (GRCm39)	F385L	possibly damaging	Het
Nebl	C	T	2: 17,457,295 (GRCm39)		probably benign	Het
Nusap1	A	G	2: 119,466,061 (GRCm39)	E227G	probably damaging	Het
Or4b13	A	G	2: 90,082,652 (GRCm39)	S227P	probably damaging	Het
Or51m1	T	G	7: 103,578,336 (GRCm39)	M102R	probably damaging	Het
Or52e3	A	C	7: 102,869,447 (GRCm39)	N174T	probably benign	Het
Pamr1	A	T	2: 102,472,486 (GRCm39)	H595L	probably benign	Het
Pate5	C	T	9: 35,750,345 (GRCm39)	G109D	probably damaging	Het
Pdgfc	G	A	3: 80,944,864 (GRCm39)		probably benign	Het
Pierce1	T	C	2: 28,355,192 (GRCm39)	N91S	probably damaging	Het
Ptpn22	A	T	3: 103,793,349 (GRCm39)	E500V	probably damaging	Het
Ptprg	G	T	14: 12,225,617 (GRCm38)		probably null	Het
R3hdm2	T	C	10: 127,319,929 (GRCm39)	F513L	probably benign	Het
Ramac	T	C	7: 81,417,473 (GRCm39)		probably null	Het
Rhobtb3	C	A	13: 76,059,056 (GRCm39)	L247F	probably damaging	Het
Scfd1	T	C	12: 51,469,756 (GRCm39)	S434P	probably benign	Het
Serpinb3d	T	A	1: 107,010,526 (GRCm39)		probably null	Het
Sin3b	T	C	8: 73,460,081 (GRCm39)	F223L	possibly damaging	Het
Slc9c1	T	C	16: 45,370,548 (GRCm39)	V263A	possibly damaging	Het
Sntb1	A	G	15: 55,655,596 (GRCm39)	S207P	possibly damaging	Het
Sqor	A	T	2: 122,641,682 (GRCm39)	T1S	possibly damaging	Het
Srrm1	G	A	4: 135,052,415 (GRCm39)	P658L	unknown	Het
Ssh2	A	G	11: 77,328,602 (GRCm39)		probably null	Het
Tasor2	A	G	13: 3,623,626 (GRCm39)	V2108A	probably benign	Het
Tmod2	A	G	9: 75,493,454 (GRCm39)	V167A	possibly damaging	Het
Trak2	G	A	1: 58,949,222 (GRCm39)	T526M	probably benign	Het
Trdn	G	A	10: 33,344,195 (GRCm39)		probably null	Het
Trim5	T	A	7: 103,927,672 (GRCm39)	E156V	probably benign	Het
Twf1	A	G	15: 94,478,890 (GRCm39)	S273P	probably damaging	Het
Xylt1	T	C	7: 117,191,164 (GRCm39)	V320A	possibly damaging	Het
Zfp518a	G	A	19: 40,903,061 (GRCm39)	G997R	probably damaging	Het

Other mutations in Mdp1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03194:Mdp1	APN	14	55,896,444 (GRCm39)	missense	probably damaging	0.98
R0373:Mdp1	UTSW	14	55,896,832 (GRCm39)	missense	probably damaging	1.00
R0685:Mdp1	UTSW	14	55,896,726 (GRCm39)	nonsense	probably null
R5007:Mdp1	UTSW	14	55,896,683 (GRCm39)	missense	probably damaging	1.00
R5008:Mdp1	UTSW	14	55,896,683 (GRCm39)	missense	probably damaging	1.00
R5009:Mdp1	UTSW	14	55,896,683 (GRCm39)	missense	probably damaging	1.00
R5371:Mdp1	UTSW	14	55,897,806 (GRCm39)	missense	probably damaging	1.00
R5654:Mdp1	UTSW	14	55,896,465 (GRCm39)	missense	probably damaging	1.00
R6489:Mdp1	UTSW	14	55,897,848 (GRCm39)	unclassified	probably benign
R7267:Mdp1	UTSW	14	55,897,544 (GRCm39)	missense	probably damaging	0.99
R8040:Mdp1	UTSW	14	55,897,523 (GRCm39)	missense	probably benign
R9642:Mdp1	UTSW	14	55,896,933 (GRCm39)	missense	probably damaging	1.00
R9696:Mdp1	UTSW	14	55,896,704 (GRCm39)	missense	probably benign	0.06

Posted On

2015-04-16