Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02735:Vmn2r103'

305595

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r103

Ensembl Gene

ENSMUSG00000091771

Gene Name

vomeronasal 2, receptor 103

Synonyms

EG627636

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.058) question?

Stock #

IGL02735

Quality Score

Status

Chromosome

Chromosomal Location

19993625-20032798 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 20032510 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Isoleucine at position 761 (M761I)

Ref Sequence

ENSEMBL: ENSMUSP00000126756 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172203]

AlphaFold

E9PWW0

Predicted Effect

probably benign
Transcript: ENSMUST00000172203
AA Change: M761I

PolyPhen 2 Score 0.273 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000126756
Gene: ENSMUSG00000091771
AA Change: M761I

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	449	1.3e-37	PFAM
Pfam:NCD3G	509	562	3.5e-22	PFAM
Pfam:7tm_3	595	830	1.1e-51	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A930011G23Rik	G	A	5: 99,377,241 (GRCm39)	P402L	probably damaging	Het
A930011G23Rik	A	G	5: 99,377,236 (GRCm39)	S404P	probably damaging	Het
Acss1	A	T	2: 150,480,387 (GRCm39)	V228E	probably damaging	Het
Ampd1	T	A	3: 102,992,693 (GRCm39)	M145K	probably damaging	Het
Ankhd1	G	A	18: 36,781,599 (GRCm39)	S2217N	probably benign	Het
Asph	T	A	4: 9,598,759 (GRCm39)	D211V	probably damaging	Het
Cd55b	A	T	1: 130,316,413 (GRCm39)	W379R	probably damaging	Het
Derl3	A	G	10: 75,730,950 (GRCm39)	T201A	probably damaging	Het
Efcab6	A	G	15: 83,783,898 (GRCm39)	L1008P	probably damaging	Het
Eif4g3	A	G	4: 137,853,522 (GRCm39)	I363V	probably benign	Het
Heatr5a	A	G	12: 51,961,804 (GRCm39)	F1058L	probably damaging	Het
Hmcn1	A	T	1: 150,522,583 (GRCm39)	M3439K	probably benign	Het
Ift140	C	A	17: 25,253,009 (GRCm39)		probably benign	Het
Itgad	A	G	7: 127,792,888 (GRCm39)	Y832C	probably damaging	Het
Itgb2	T	A	10: 77,385,833 (GRCm39)	D265E	possibly damaging	Het
Kif19a	A	T	11: 114,676,393 (GRCm39)	E449V	probably damaging	Het
Krt40	T	C	11: 99,429,461 (GRCm39)	E291G	probably damaging	Het
Lama2	T	C	10: 26,980,124 (GRCm39)	N1897S	probably damaging	Het
Lepr	A	G	4: 101,639,835 (GRCm39)	Y767C	probably damaging	Het
Lrrtm4	A	G	6: 80,786,031 (GRCm39)	H546R	probably benign	Het
Marchf6	A	G	15: 31,486,266 (GRCm39)	S362P	probably benign	Het
Med12l	A	G	3: 59,001,067 (GRCm39)	Y734C	probably damaging	Het
Mrps18a	C	T	17: 46,433,725 (GRCm39)	R74C	probably damaging	Het
Mvk	A	G	5: 114,588,880 (GRCm39)	E174G	probably benign	Het
Naip2	A	G	13: 100,296,722 (GRCm39)	S1105P	probably damaging	Het
Nrxn3	A	G	12: 89,221,624 (GRCm39)	M468V	probably benign	Het
Obscn	T	C	11: 58,984,175 (GRCm39)	E1760G	probably damaging	Het
Pcsk5	C	A	19: 17,652,832 (GRCm39)	G285W	probably damaging	Het
Pgpep1l	A	G	7: 67,886,721 (GRCm39)	I196T	probably benign	Het
Phf14	T	C	6: 11,987,611 (GRCm39)	M630T	probably benign	Het
Plod2	T	C	9: 92,477,442 (GRCm39)		probably benign	Het
Poldip2	G	A	11: 78,403,162 (GRCm39)	A9T	probably benign	Het
Pou2f1	A	G	1: 165,703,396 (GRCm39)	S718P	probably damaging	Het
Pramel34	G	A	5: 93,786,503 (GRCm39)	P89S	possibly damaging	Het
Ptpre	A	T	7: 135,269,296 (GRCm39)	Y246F	probably damaging	Het
Pudp	T	C	18: 50,701,403 (GRCm39)	H110R	probably benign	Het
Scaf4	C	T	16: 90,042,403 (GRCm39)	G646E	unknown	Het
Sec16a	T	A	2: 26,318,149 (GRCm39)		probably benign	Het
Serpina5	A	G	12: 104,070,116 (GRCm39)	T338A	probably benign	Het
Shisa5	T	G	9: 108,885,080 (GRCm39)	F118V	probably damaging	Het
Slc6a21	G	A	7: 44,936,061 (GRCm39)		probably benign	Het
Sprtn	T	A	8: 125,630,126 (GRCm39)	V473E	probably benign	Het
Styxl1	A	G	5: 135,787,996 (GRCm39)	I165T	probably damaging	Het
Tal2	T	A	4: 53,785,906 (GRCm39)	I29N	probably damaging	Het
Tas2r134	T	C	2: 51,517,839 (GRCm39)	I106T	probably damaging	Het
Tmem259	G	A	10: 79,814,973 (GRCm39)	T217I	probably damaging	Het
Trpc6	T	C	9: 8,655,339 (GRCm39)	I723T	probably damaging	Het
Vmn1r211	A	T	13: 23,036,418 (GRCm39)	V83D	probably damaging	Het
Ybey	A	T	10: 76,304,160 (GRCm39)	I14N	probably damaging	Het

Other mutations in Vmn2r103

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00333:Vmn2r103	APN	17	20,013,364 (GRCm39)	missense	probably damaging	0.98
IGL00939:Vmn2r103	APN	17	20,015,227 (GRCm39)	missense	probably benign	0.00
IGL01120:Vmn2r103	APN	17	20,013,259 (GRCm39)	missense	probably benign	0.06
IGL01403:Vmn2r103	APN	17	20,013,229 (GRCm39)	missense	probably benign
IGL01404:Vmn2r103	APN	17	20,032,696 (GRCm39)	missense	probably damaging	1.00
IGL01713:Vmn2r103	APN	17	20,014,330 (GRCm39)	missense	probably damaging	1.00
IGL01802:Vmn2r103	APN	17	20,019,470 (GRCm39)	missense	probably benign
IGL02251:Vmn2r103	APN	17	20,014,231 (GRCm39)	missense	possibly damaging	0.84
IGL02466:Vmn2r103	APN	17	19,993,631 (GRCm39)	missense	probably benign
IGL02555:Vmn2r103	APN	17	20,031,873 (GRCm39)	missense	probably damaging	1.00
IGL02668:Vmn2r103	APN	17	20,014,389 (GRCm39)	missense	probably benign	0.03
IGL02715:Vmn2r103	APN	17	20,014,218 (GRCm39)	missense	probably damaging	0.97
IGL03101:Vmn2r103	APN	17	19,993,782 (GRCm39)	missense	probably damaging	0.98
R0003:Vmn2r103	UTSW	17	20,032,241 (GRCm39)	missense	probably damaging	0.99
R0052:Vmn2r103	UTSW	17	20,031,903 (GRCm39)	missense	probably benign	0.01
R0375:Vmn2r103	UTSW	17	20,013,726 (GRCm39)	missense	probably benign	0.12
R0375:Vmn2r103	UTSW	17	20,013,121 (GRCm39)	missense	probably benign	0.06
R0755:Vmn2r103	UTSW	17	19,993,830 (GRCm39)	missense	probably benign	0.01
R0837:Vmn2r103	UTSW	17	20,014,189 (GRCm39)	missense	probably damaging	0.99
R1345:Vmn2r103	UTSW	17	20,014,509 (GRCm39)	missense	probably damaging	1.00
R1396:Vmn2r103	UTSW	17	20,013,230 (GRCm39)	missense	probably benign
R1488:Vmn2r103	UTSW	17	20,013,922 (GRCm39)	missense	probably damaging	0.97
R1533:Vmn2r103	UTSW	17	19,993,662 (GRCm39)	missense	probably benign	0.01
R1590:Vmn2r103	UTSW	17	20,014,496 (GRCm39)	missense	probably benign
R1928:Vmn2r103	UTSW	17	20,032,029 (GRCm39)	missense	possibly damaging	0.95
R1942:Vmn2r103	UTSW	17	20,032,562 (GRCm39)	missense	probably benign	0.02
R2071:Vmn2r103	UTSW	17	20,014,056 (GRCm39)	missense	probably benign
R2219:Vmn2r103	UTSW	17	20,013,909 (GRCm39)	missense	probably damaging	1.00
R2442:Vmn2r103	UTSW	17	19,993,793 (GRCm39)	missense	probably benign	0.00
R2889:Vmn2r103	UTSW	17	20,013,862 (GRCm39)	missense	probably damaging	1.00
R3762:Vmn2r103	UTSW	17	20,032,411 (GRCm39)	missense	probably damaging	0.98
R4014:Vmn2r103	UTSW	17	20,013,866 (GRCm39)	missense	possibly damaging	0.67
R4331:Vmn2r103	UTSW	17	20,014,495 (GRCm39)	missense	probably benign	0.00
R4630:Vmn2r103	UTSW	17	20,013,958 (GRCm39)	missense	probably benign	0.04
R4631:Vmn2r103	UTSW	17	20,013,958 (GRCm39)	missense	probably benign	0.04
R4632:Vmn2r103	UTSW	17	20,013,958 (GRCm39)	missense	probably benign	0.04
R4660:Vmn2r103	UTSW	17	20,032,077 (GRCm39)	missense	probably damaging	1.00
R4801:Vmn2r103	UTSW	17	20,015,338 (GRCm39)	missense	probably benign	0.06
R4802:Vmn2r103	UTSW	17	20,015,338 (GRCm39)	missense	probably benign	0.06
R4931:Vmn2r103	UTSW	17	20,032,031 (GRCm39)	missense	probably benign	0.01
R4995:Vmn2r103	UTSW	17	19,993,773 (GRCm39)	missense	probably benign	0.14
R5309:Vmn2r103	UTSW	17	20,013,296 (GRCm39)	missense	probably benign	0.01
R5312:Vmn2r103	UTSW	17	20,013,296 (GRCm39)	missense	probably benign	0.01
R5329:Vmn2r103	UTSW	17	20,032,433 (GRCm39)	missense	probably damaging	1.00
R5611:Vmn2r103	UTSW	17	20,013,904 (GRCm39)	missense	probably damaging	0.99
R5684:Vmn2r103	UTSW	17	20,013,251 (GRCm39)	missense	probably benign	0.02
R5715:Vmn2r103	UTSW	17	20,015,201 (GRCm39)	missense	probably benign	0.17
R5907:Vmn2r103	UTSW	17	20,032,715 (GRCm39)	missense	possibly damaging	0.67
R6029:Vmn2r103	UTSW	17	20,014,478 (GRCm39)	nonsense	probably null
R6114:Vmn2r103	UTSW	17	20,032,587 (GRCm39)	missense	probably damaging	0.99
R6285:Vmn2r103	UTSW	17	20,032,406 (GRCm39)	missense	probably benign
R6292:Vmn2r103	UTSW	17	20,013,866 (GRCm39)	missense	possibly damaging	0.67
R6334:Vmn2r103	UTSW	17	20,014,344 (GRCm39)	missense	probably damaging	0.97
R6501:Vmn2r103	UTSW	17	20,032,166 (GRCm39)	missense	probably benign	0.29
R6710:Vmn2r103	UTSW	17	20,032,239 (GRCm39)	missense	probably damaging	1.00
R6774:Vmn2r103	UTSW	17	19,993,773 (GRCm39)	missense	probably benign	0.14
R6981:Vmn2r103	UTSW	17	20,013,739 (GRCm39)	missense	probably benign	0.00
R7768:Vmn2r103	UTSW	17	20,032,314 (GRCm39)	missense	probably damaging	0.99
R7816:Vmn2r103	UTSW	17	20,014,476 (GRCm39)	missense	probably benign	0.06
R7885:Vmn2r103	UTSW	17	20,013,385 (GRCm39)	missense	probably benign	0.25
R8002:Vmn2r103	UTSW	17	20,019,511 (GRCm39)	missense	probably damaging	1.00
R8031:Vmn2r103	UTSW	17	20,013,759 (GRCm39)	missense	probably benign	0.00
R8140:Vmn2r103	UTSW	17	20,032,058 (GRCm39)	missense	probably damaging	1.00
R8186:Vmn2r103	UTSW	17	20,032,205 (GRCm39)	missense	probably damaging	1.00
R8559:Vmn2r103	UTSW	17	20,032,646 (GRCm39)	missense	probably benign	0.01
R9413:Vmn2r103	UTSW	17	20,032,158 (GRCm39)	missense	possibly damaging	0.54
R9591:Vmn2r103	UTSW	17	20,031,921 (GRCm39)	missense	possibly damaging	0.70
R9652:Vmn2r103	UTSW	17	20,014,027 (GRCm39)	missense	probably benign	0.01
R9680:Vmn2r103	UTSW	17	20,019,525 (GRCm39)	nonsense	probably null
R9743:Vmn2r103	UTSW	17	20,032,475 (GRCm39)	missense	probably damaging	1.00
Z1088:Vmn2r103	UTSW	17	20,015,309 (GRCm39)	missense	probably benign	0.08

Posted On

2015-04-16