Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02742:Vmn1r123'

305931

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r123

Ensembl Gene

ENSMUSG00000094385

Gene Name

vomeronasal 1 receptor 123

Synonyms

LOC384695, Gm1446

Accession Numbers

Essential gene?

Not available question?

Stock #

IGL02742

Quality Score

Status

Chromosome

Chromosomal Location

20896110-20897033 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 20896968 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 287 (I287F)

Ref Sequence

ENSEMBL: ENSMUSP00000125823 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000166948]

AlphaFold

L7N270

Predicted Effect

possibly damaging
Transcript: ENSMUST00000166948
AA Change: I287F

PolyPhen 2 Score 0.930 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000125823
Gene: ENSMUSG00000094385
AA Change: I287F

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	299	7e-18	PFAM
Pfam:7tm_1	31	291	2.1e-8	PFAM
Pfam:V1R	41	298	1.9e-16	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acad11	A	G	9: 103,972,824 (GRCm39)	T506A	probably damaging	Het
Ankib1	A	C	5: 3,743,479 (GRCm39)	D845E	probably benign	Het
Atxn2	T	C	5: 121,919,399 (GRCm39)	V369A	possibly damaging	Het
Ccdc50	T	A	16: 27,225,534 (GRCm39)		probably benign	Het
Clec2g	A	G	6: 128,957,224 (GRCm39)	I61V	possibly damaging	Het
Col16a1	G	A	4: 129,955,172 (GRCm39)		probably benign	Het
Dapk2	A	G	9: 66,139,096 (GRCm39)	Y139C	probably damaging	Het
Ecpas	A	G	4: 58,840,757 (GRCm39)	V667A	probably damaging	Het
Fnip1	T	C	11: 54,384,177 (GRCm39)	L334P	probably damaging	Het
Igf1r	A	G	7: 67,839,739 (GRCm39)	E682G	possibly damaging	Het
Ints8	T	C	4: 11,241,627 (GRCm39)	E272G	possibly damaging	Het
Jph2	G	A	2: 163,217,699 (GRCm39)	P326S	probably damaging	Het
Krtap1-4	T	C	11: 99,473,940 (GRCm39)		probably benign	Het
Lrp5	A	G	19: 3,654,022 (GRCm39)	I1135T	probably damaging	Het
Lrrk1	A	G	7: 65,958,439 (GRCm39)	V320A	probably benign	Het
Myh6	A	C	14: 55,191,381 (GRCm39)	I820S	possibly damaging	Het
Napg	A	T	18: 63,119,319 (GRCm39)	T110S	probably damaging	Het
Nova1	G	A	12: 46,767,475 (GRCm39)	Q56*	probably null	Het
Phyhip	A	G	14: 70,699,367 (GRCm39)		probably null	Het
Pkd2l2	C	A	18: 34,549,970 (GRCm39)	S205*	probably null	Het
Ppp2r1a	G	T	17: 21,179,265 (GRCm39)	C101F	probably benign	Het
Serpinb3c	G	A	1: 107,200,872 (GRCm39)	R182*	probably null	Het
St18	A	C	1: 6,872,540 (GRCm39)		probably benign	Het
St6galnac4	C	T	2: 32,487,096 (GRCm39)	R264C	possibly damaging	Het
Tmem168	T	C	6: 13,603,261 (GRCm39)	Y35C	probably benign	Het
Tmem219	A	G	7: 126,496,220 (GRCm39)	L74P	probably damaging	Het
Trpc4	T	A	3: 54,206,667 (GRCm39)	N622K	probably damaging	Het
Trpm6	A	C	19: 18,807,376 (GRCm39)		probably benign	Het
Ttl	C	A	2: 128,908,213 (GRCm39)	F49L	possibly damaging	Het
Tut7	C	T	13: 59,964,156 (GRCm39)	D250N	probably damaging	Het
Vmn2r97	T	G	17: 19,149,432 (GRCm39)	I273M	probably damaging	Het
Wdr5	C	A	2: 27,410,437 (GRCm39)		probably benign	Het
Zfp37	C	A	4: 62,110,548 (GRCm39)	C172F	possibly damaging	Het

Other mutations in Vmn1r123

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00927:Vmn1r123	APN	7	20,896,216 (GRCm39)	missense	possibly damaging	0.93
IGL02330:Vmn1r123	APN	7	20,896,969 (GRCm39)	missense	probably damaging	0.99
IGL03240:Vmn1r123	APN	7	20,896,282 (GRCm39)	missense	possibly damaging	0.94
R1173:Vmn1r123	UTSW	7	20,896,257 (GRCm39)	missense	probably damaging	0.99
R6278:Vmn1r123	UTSW	7	20,896,774 (GRCm39)	missense	possibly damaging	0.78
R6610:Vmn1r123	UTSW	7	20,896,515 (GRCm39)	missense	probably benign	0.00
R6679:Vmn1r123	UTSW	7	20,896,868 (GRCm39)	nonsense	probably null
R7241:Vmn1r123	UTSW	7	20,896,537 (GRCm39)	missense	possibly damaging	0.95
R7642:Vmn1r123	UTSW	7	20,896,795 (GRCm39)	missense	probably benign	0.11
R7702:Vmn1r123	UTSW	7	20,896,302 (GRCm39)	missense	probably damaging	0.99
R7870:Vmn1r123	UTSW	7	20,896,192 (GRCm39)	missense	probably damaging	1.00
R7981:Vmn1r123	UTSW	7	20,896,914 (GRCm39)	missense	probably damaging	0.98
R8554:Vmn1r123	UTSW	7	20,896,971 (GRCm39)	missense	probably benign
R9079:Vmn1r123	UTSW	7	20,896,979 (GRCm39)	missense	probably benign	0.01
R9090:Vmn1r123	UTSW	7	20,896,794 (GRCm39)	missense	probably benign
R9271:Vmn1r123	UTSW	7	20,896,794 (GRCm39)	missense	probably benign
R9544:Vmn1r123	UTSW	7	20,896,987 (GRCm39)	missense	probably benign	0.30
R9779:Vmn1r123	UTSW	7	20,896,111 (GRCm39)	start codon destroyed	probably null	0.99

Posted On

2015-04-16