Incidental Mutation 'IGL02744:Gm8206'
ID305995
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm8206
Ensembl Gene ENSMUSG00000091568
Gene Namepredicted gene 8206
Synonyms
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL02744
Quality Score
Status
Chromosome14
Chromosomal Location6016759-6093942 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 6022488 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Valine at position 4 (I4V)
Ref Sequence ENSEMBL: ENSMUSP00000127533 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000164139] [ENSMUST00000168733] [ENSMUST00000171428]
Predicted Effect probably benign
Transcript: ENSMUST00000164139
AA Change: I4V

PolyPhen 2 Score 0.090 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000128269
Gene: ENSMUSG00000091568
AA Change: I4V

DomainStartEndE-ValueType
Pfam:Takusan 1 57 2.2e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000168733
SMART Domains Protein: ENSMUSP00000129374
Gene: ENSMUSG00000091568

DomainStartEndE-ValueType
Pfam:Takusan 46 129 1.2e-32 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000171428
AA Change: I4V

PolyPhen 2 Score 0.468 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000127533
Gene: ENSMUSG00000091568
AA Change: I4V

DomainStartEndE-ValueType
Pfam:Takusan 1 56 1.2e-16 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930564D02Rik A G 3: 105,078,536 M89V unknown Het
Actl11 C A 9: 107,929,862 H461Q probably benign Het
Aox4 A T 1: 58,255,552 R973S possibly damaging Het
Arhgef10 C T 8: 14,930,198 A146V probably benign Het
Cep350 A T 1: 155,931,533 S713T probably damaging Het
Doxl2 A G 6: 48,975,315 E58G probably benign Het
Epha5 T C 5: 84,107,989 I458V probably benign Het
Galnt17 A G 5: 131,111,775 I168T probably damaging Het
Gli3 T C 13: 15,613,886 probably null Het
Gm11110 T A 17: 57,092,693 probably benign Het
Gm8906 C T 5: 11,505,373 T103I possibly damaging Het
Golga1 A G 2: 39,018,474 S713P probably damaging Het
Ing5 T C 1: 93,816,488 M172T probably damaging Het
Lyn A G 4: 3,738,808 T27A probably benign Het
Olfr1367 A G 13: 21,346,994 Y22C probably damaging Het
Pou5f1 T C 17: 35,509,414 V40A probably damaging Het
Pramef12 A T 4: 144,392,923 L358Q probably damaging Het
Prdm16 A G 4: 154,345,453 L353P probably damaging Het
Psg18 T A 7: 18,349,402 Q276L probably benign Het
Ralgapb A C 2: 158,446,151 Q369H probably damaging Het
Slc44a4 A G 17: 34,927,800 N300D probably damaging Het
Slc6a15 A T 10: 103,418,033 E610V probably benign Het
Slc8a2 T C 7: 16,145,029 V480A possibly damaging Het
Spg7 T C 8: 123,093,661 F617S probably damaging Het
Srcap A G 7: 127,534,666 D863G probably damaging Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
Suox T C 10: 128,671,217 E314G probably benign Het
Tln2 T A 9: 67,229,376 K1276* probably null Het
Tmem72 A G 6: 116,695,490 L130P probably damaging Het
Ttll1 T C 15: 83,489,577 Y345C probably benign Het
Ush2a A T 1: 188,358,717 probably null Het
Xpo6 G A 7: 126,108,448 probably benign Het
Zc3h14 A T 12: 98,784,975 Y512F possibly damaging Het
Zfp438 A T 18: 5,214,760 M66K probably benign Het
Other mutations in Gm8206
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01823:Gm8206 APN 14 6017078 missense probably benign
R1933:Gm8206 UTSW 14 6022475 missense probably benign 0.19
Posted On2015-04-16