Incidental Mutation 'IGL02744:Zfp438'
ID306003
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp438
Ensembl Gene ENSMUSG00000050945
Gene Namezinc finger protein 438
Synonyms
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.291) question?
Stock #IGL02744
Quality Score
Status
Chromosome18
Chromosomal Location5210031-5334439 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 5214760 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Lysine at position 66 (M66K)
Ref Sequence ENSEMBL: ENSMUSP00000067049 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000063989]
Predicted Effect probably benign
Transcript: ENSMUST00000063989
AA Change: M66K

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000067049
Gene: ENSMUSG00000050945
AA Change: M66K

DomainStartEndE-ValueType
low complexity region 132 151 N/A INTRINSIC
low complexity region 263 274 N/A INTRINSIC
low complexity region 427 439 N/A INTRINSIC
ZnF_C2H2 493 515 5.72e-1 SMART
ZnF_C2H2 521 543 7.26e-3 SMART
ZnF_C2H2 553 576 5.2e0 SMART
ZnF_C2H2 635 658 1.86e1 SMART
ZnF_C2H2 746 769 1.13e1 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930564D02Rik A G 3: 105,078,536 M89V unknown Het
Actl11 C A 9: 107,929,862 H461Q probably benign Het
Aox4 A T 1: 58,255,552 R973S possibly damaging Het
Arhgef10 C T 8: 14,930,198 A146V probably benign Het
Cep350 A T 1: 155,931,533 S713T probably damaging Het
Doxl2 A G 6: 48,975,315 E58G probably benign Het
Epha5 T C 5: 84,107,989 I458V probably benign Het
Galnt17 A G 5: 131,111,775 I168T probably damaging Het
Gli3 T C 13: 15,613,886 probably null Het
Gm11110 T A 17: 57,092,693 probably benign Het
Gm8206 T C 14: 6,022,488 I4V possibly damaging Het
Gm8906 C T 5: 11,505,373 T103I possibly damaging Het
Golga1 A G 2: 39,018,474 S713P probably damaging Het
Ing5 T C 1: 93,816,488 M172T probably damaging Het
Lyn A G 4: 3,738,808 T27A probably benign Het
Olfr1367 A G 13: 21,346,994 Y22C probably damaging Het
Pou5f1 T C 17: 35,509,414 V40A probably damaging Het
Pramef12 A T 4: 144,392,923 L358Q probably damaging Het
Prdm16 A G 4: 154,345,453 L353P probably damaging Het
Psg18 T A 7: 18,349,402 Q276L probably benign Het
Ralgapb A C 2: 158,446,151 Q369H probably damaging Het
Slc44a4 A G 17: 34,927,800 N300D probably damaging Het
Slc6a15 A T 10: 103,418,033 E610V probably benign Het
Slc8a2 T C 7: 16,145,029 V480A possibly damaging Het
Spg7 T C 8: 123,093,661 F617S probably damaging Het
Srcap A G 7: 127,534,666 D863G probably damaging Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
Suox T C 10: 128,671,217 E314G probably benign Het
Tln2 T A 9: 67,229,376 K1276* probably null Het
Tmem72 A G 6: 116,695,490 L130P probably damaging Het
Ttll1 T C 15: 83,489,577 Y345C probably benign Het
Ush2a A T 1: 188,358,717 probably null Het
Xpo6 G A 7: 126,108,448 probably benign Het
Zc3h14 A T 12: 98,784,975 Y512F possibly damaging Het
Other mutations in Zfp438
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01907:Zfp438 APN 18 5213815 missense probably damaging 1.00
IGL01967:Zfp438 APN 18 5214049 missense probably benign 0.00
IGL02003:Zfp438 APN 18 5214503 missense probably benign 0.15
IGL02305:Zfp438 APN 18 5213674 missense possibly damaging 0.84
IGL02439:Zfp438 APN 18 5213216 missense probably damaging 1.00
IGL02836:Zfp438 APN 18 5245427 utr 5 prime probably benign
R0308:Zfp438 UTSW 18 5213638 missense probably benign 0.00
R0437:Zfp438 UTSW 18 5214910 missense probably damaging 0.97
R1540:Zfp438 UTSW 18 5210740 missense probably benign 0.04
R1594:Zfp438 UTSW 18 5213515 missense possibly damaging 0.94
R1804:Zfp438 UTSW 18 5213689 missense probably damaging 1.00
R2057:Zfp438 UTSW 18 5214085 missense probably benign 0.03
R2256:Zfp438 UTSW 18 5213508 missense probably damaging 0.99
R4549:Zfp438 UTSW 18 5214073 missense probably benign 0.01
R4747:Zfp438 UTSW 18 5214403 missense probably benign 0.00
R4858:Zfp438 UTSW 18 5213154 missense probably benign 0.01
R4887:Zfp438 UTSW 18 5213776 missense possibly damaging 0.55
R5543:Zfp438 UTSW 18 5213761 missense probably damaging 1.00
R5646:Zfp438 UTSW 18 5214526 missense probably benign 0.36
R6022:Zfp438 UTSW 18 5213419 missense probably damaging 1.00
R6058:Zfp438 UTSW 18 5213209 missense probably damaging 1.00
R6460:Zfp438 UTSW 18 5213603 missense probably damaging 1.00
R6703:Zfp438 UTSW 18 5214044 missense probably benign 0.05
R6766:Zfp438 UTSW 18 5213780 missense probably benign 0.07
R7252:Zfp438 UTSW 18 5214874 nonsense probably null
R7283:Zfp438 UTSW 18 5214712 missense probably damaging 1.00
Posted On2015-04-16