Incidental Mutation 'IGL02744:Olfr1367'
ID306011
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1367
Ensembl Gene ENSMUSG00000045508
Gene Nameolfactory receptor 1367
SynonymsMOR256-16, MOR256-65, GA_x6K02T2QHY8-11899770-11898820
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.067) question?
Stock #IGL02744
Quality Score
Status
Chromosome13
Chromosomal Location21346910-21347964 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 21346994 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Cysteine at position 22 (Y22C)
Ref Sequence ENSEMBL: ENSMUSP00000055870 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059216]
Predicted Effect probably damaging
Transcript: ENSMUST00000059216
AA Change: Y22C

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000055870
Gene: ENSMUSG00000045508
AA Change: Y22C

DomainStartEndE-ValueType
Pfam:7tm_4 33 310 2.6e-54 PFAM
Pfam:7TM_GPCR_Srsx 37 153 9.3e-7 PFAM
Pfam:7tm_1 43 292 4.5e-25 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930564D02Rik A G 3: 105,078,536 M89V unknown Het
Actl11 C A 9: 107,929,862 H461Q probably benign Het
Aox4 A T 1: 58,255,552 R973S possibly damaging Het
Arhgef10 C T 8: 14,930,198 A146V probably benign Het
Cep350 A T 1: 155,931,533 S713T probably damaging Het
Doxl2 A G 6: 48,975,315 E58G probably benign Het
Epha5 T C 5: 84,107,989 I458V probably benign Het
Galnt17 A G 5: 131,111,775 I168T probably damaging Het
Gli3 T C 13: 15,613,886 probably null Het
Gm11110 T A 17: 57,092,693 probably benign Het
Gm8206 T C 14: 6,022,488 I4V possibly damaging Het
Gm8906 C T 5: 11,505,373 T103I possibly damaging Het
Golga1 A G 2: 39,018,474 S713P probably damaging Het
Ing5 T C 1: 93,816,488 M172T probably damaging Het
Lyn A G 4: 3,738,808 T27A probably benign Het
Pou5f1 T C 17: 35,509,414 V40A probably damaging Het
Pramef12 A T 4: 144,392,923 L358Q probably damaging Het
Prdm16 A G 4: 154,345,453 L353P probably damaging Het
Psg18 T A 7: 18,349,402 Q276L probably benign Het
Ralgapb A C 2: 158,446,151 Q369H probably damaging Het
Slc44a4 A G 17: 34,927,800 N300D probably damaging Het
Slc6a15 A T 10: 103,418,033 E610V probably benign Het
Slc8a2 T C 7: 16,145,029 V480A possibly damaging Het
Spg7 T C 8: 123,093,661 F617S probably damaging Het
Srcap A G 7: 127,534,666 D863G probably damaging Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
Suox T C 10: 128,671,217 E314G probably benign Het
Tln2 T A 9: 67,229,376 K1276* probably null Het
Tmem72 A G 6: 116,695,490 L130P probably damaging Het
Ttll1 T C 15: 83,489,577 Y345C probably benign Het
Ush2a A T 1: 188,358,717 probably null Het
Xpo6 G A 7: 126,108,448 probably benign Het
Zc3h14 A T 12: 98,784,975 Y512F possibly damaging Het
Zfp438 A T 18: 5,214,760 M66K probably benign Het
Other mutations in Olfr1367
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01081:Olfr1367 APN 13 21347015 missense probably damaging 0.99
IGL01327:Olfr1367 APN 13 21347207 missense probably benign 0.00
IGL02624:Olfr1367 APN 13 21347512 missense probably benign 0.11
IGL02718:Olfr1367 APN 13 21347384 missense probably damaging 1.00
IGL03354:Olfr1367 APN 13 21347516 missense possibly damaging 0.65
R1433:Olfr1367 UTSW 13 21347024 missense probably benign 0.00
R1567:Olfr1367 UTSW 13 21347425 missense probably benign 0.00
R1857:Olfr1367 UTSW 13 21347176 missense possibly damaging 0.63
R1858:Olfr1367 UTSW 13 21347176 missense possibly damaging 0.63
R1927:Olfr1367 UTSW 13 21346946 missense probably benign 0.04
R4627:Olfr1367 UTSW 13 21347464 missense probably damaging 1.00
R6146:Olfr1367 UTSW 13 21346994 missense possibly damaging 0.49
Posted On2015-04-16