Incidental Mutation 'IGL02744:Gm8906'
ID306015
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm8906
Ensembl Gene ENSMUSG00000095296
Gene Namepredicted gene 8906
Synonyms
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL02744
Quality Score
Status
Chromosome5
Chromosomal Location11502685-11507417 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 11505373 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Isoleucine at position 103 (T103I)
Ref Sequence ENSEMBL: ENSMUSP00000136666 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000164651] [ENSMUST00000179375]
Predicted Effect possibly damaging
Transcript: ENSMUST00000164651
AA Change: T130I

PolyPhen 2 Score 0.655 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000128633
Gene: ENSMUSG00000095296
AA Change: T130I

DomainStartEndE-ValueType
Pfam:Takusan 30 116 3e-25 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000179375
AA Change: T103I

PolyPhen 2 Score 0.934 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000136666
Gene: ENSMUSG00000095296
AA Change: T103I

DomainStartEndE-ValueType
Pfam:Takusan 2 90 5.6e-30 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197456
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930564D02Rik A G 3: 105,078,536 M89V unknown Het
Actl11 C A 9: 107,929,862 H461Q probably benign Het
Aox4 A T 1: 58,255,552 R973S possibly damaging Het
Arhgef10 C T 8: 14,930,198 A146V probably benign Het
Cep350 A T 1: 155,931,533 S713T probably damaging Het
Doxl2 A G 6: 48,975,315 E58G probably benign Het
Epha5 T C 5: 84,107,989 I458V probably benign Het
Galnt17 A G 5: 131,111,775 I168T probably damaging Het
Gli3 T C 13: 15,613,886 probably null Het
Gm11110 T A 17: 57,092,693 probably benign Het
Gm8206 T C 14: 6,022,488 I4V possibly damaging Het
Golga1 A G 2: 39,018,474 S713P probably damaging Het
Ing5 T C 1: 93,816,488 M172T probably damaging Het
Lyn A G 4: 3,738,808 T27A probably benign Het
Olfr1367 A G 13: 21,346,994 Y22C probably damaging Het
Pou5f1 T C 17: 35,509,414 V40A probably damaging Het
Pramef12 A T 4: 144,392,923 L358Q probably damaging Het
Prdm16 A G 4: 154,345,453 L353P probably damaging Het
Psg18 T A 7: 18,349,402 Q276L probably benign Het
Ralgapb A C 2: 158,446,151 Q369H probably damaging Het
Slc44a4 A G 17: 34,927,800 N300D probably damaging Het
Slc6a15 A T 10: 103,418,033 E610V probably benign Het
Slc8a2 T C 7: 16,145,029 V480A possibly damaging Het
Spg7 T C 8: 123,093,661 F617S probably damaging Het
Srcap A G 7: 127,534,666 D863G probably damaging Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
Suox T C 10: 128,671,217 E314G probably benign Het
Tln2 T A 9: 67,229,376 K1276* probably null Het
Tmem72 A G 6: 116,695,490 L130P probably damaging Het
Ttll1 T C 15: 83,489,577 Y345C probably benign Het
Ush2a A T 1: 188,358,717 probably null Het
Xpo6 G A 7: 126,108,448 probably benign Het
Zc3h14 A T 12: 98,784,975 Y512F possibly damaging Het
Zfp438 A T 18: 5,214,760 M66K probably benign Het
Other mutations in Gm8906
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01582:Gm8906 APN 5 11505273 missense probably benign 0.05
IGL02690:Gm8906 APN 5 11505261 nonsense probably null
R4617:Gm8906 UTSW 5 11503831 missense probably benign 0.00
R7135:Gm8906 UTSW 5 11505231 missense probably damaging 0.99
Posted On2015-04-16