Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02749:Or5w10'

306179

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or5w10

Ensembl Gene

ENSMUSG00000075156

Gene Name

olfactory receptor family 5 subfamily W member 10

Synonyms

MOR176-3, Olfr1128, GA_x6K02T2Q125-49048592-49047657

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.055) question?

Stock #

IGL02749

Quality Score

Status

Chromosome

Chromosomal Location

87374951-87375886 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 87375001 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Methionine at position 296 (V296M)

Ref Sequence

ENSEMBL: ENSMUSP00000099684 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000102624]

AlphaFold

Q7TR47

Predicted Effect

probably damaging
Transcript: ENSMUST00000102624
AA Change: V296M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000099684
Gene: ENSMUSG00000075156
AA Change: V296M

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	307	5.3e-46	PFAM
Pfam:7tm_1	41	290	3.2e-16	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000120590

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9230104M06Rik	T	C	12: 112,963,795 (GRCm39)	D61G	probably benign	Het
Albfm1	T	C	5: 90,719,624 (GRCm39)	V240A	possibly damaging	Het
Ascc2	G	A	11: 4,590,481 (GRCm39)		probably null	Het
Atrn	C	T	2: 130,812,064 (GRCm39)	Q670*	probably null	Het
Atrn	G	T	2: 130,789,654 (GRCm39)		probably benign	Het
Calr	A	C	8: 85,571,117 (GRCm39)	W236G	probably damaging	Het
Camk2g	T	A	14: 20,816,084 (GRCm39)		probably null	Het
Cd101	G	T	3: 100,927,715 (GRCm39)	T122K	probably damaging	Het
Cert1	T	A	13: 96,765,643 (GRCm39)	N469K	possibly damaging	Het
Cryl1	T	C	14: 57,541,181 (GRCm39)	T168A	probably benign	Het
Diaph3	A	G	14: 87,156,261 (GRCm39)	I684T	probably damaging	Het
Ednrb	A	T	14: 104,060,495 (GRCm39)	M266K	possibly damaging	Het
Eif4h	T	C	5: 134,668,146 (GRCm39)	D3G	probably damaging	Het
Eny2	C	T	15: 44,293,031 (GRCm39)	R28C	possibly damaging	Het
Epsti1	A	G	14: 78,177,363 (GRCm39)	E181G	probably damaging	Het
Ezh2	A	G	6: 47,510,698 (GRCm39)	F598S	probably damaging	Het
Fat3	G	T	9: 15,918,007 (GRCm39)	T1472K	possibly damaging	Het
Gabra4	T	A	5: 71,795,490 (GRCm39)	I262F	probably benign	Het
Gpat4	A	T	8: 23,670,886 (GRCm39)	Y109N	probably damaging	Het
Gpsm1	C	T	2: 26,229,687 (GRCm39)	T36I	probably damaging	Het
Hikeshi	C	T	7: 89,585,097 (GRCm39)	V36I	possibly damaging	Het
Hip1	T	C	5: 135,473,605 (GRCm39)	M238V	probably benign	Het
Hnrnpll	A	T	17: 80,369,420 (GRCm39)	M1K	probably null	Het
Irx2	G	A	13: 72,779,429 (GRCm39)	D238N	probably damaging	Het
Kcnip4	T	A	5: 48,567,127 (GRCm39)		probably benign	Het
Lair1	G	A	7: 4,031,900 (GRCm39)	T69I	possibly damaging	Het
Lamc1	A	G	1: 153,125,599 (GRCm39)	I558T	possibly damaging	Het
Map4k5	C	T	12: 69,862,580 (GRCm39)	E639K	probably benign	Het
Mc4r	A	G	18: 66,992,733 (GRCm39)	S127P	probably damaging	Het
Mmp23	A	G	4: 155,735,989 (GRCm39)	M221T	possibly damaging	Het
Mre11a	T	C	9: 14,737,887 (GRCm39)	S587P	possibly damaging	Het
Myh9	A	T	15: 77,692,186 (GRCm39)	Y124*	probably null	Het
Nek9	C	A	12: 85,352,281 (GRCm39)	A861S	probably benign	Het
Nup155	T	A	15: 8,163,560 (GRCm39)	Y576N	probably damaging	Het
Pcca	A	T	14: 122,771,800 (GRCm39)	T8S	probably benign	Het
Pcdh15	A	G	10: 74,466,900 (GRCm39)	D1573G	probably benign	Het
Pdpr	T	A	8: 111,844,722 (GRCm39)	V373E	probably benign	Het
Pdzph1	A	T	17: 59,239,478 (GRCm39)	L950Q	possibly damaging	Het
Pira13	A	G	7: 3,825,624 (GRCm39)	I415T	probably damaging	Het
Prss35	A	C	9: 86,638,297 (GRCm39)	K356Q	probably damaging	Het
Psg22	A	T	7: 18,456,944 (GRCm39)	T237S	possibly damaging	Het
Rdh13	A	G	7: 4,430,703 (GRCm39)	Y252H	probably damaging	Het
Sema3d	T	C	5: 12,613,112 (GRCm39)		probably benign	Het
Slc35b2	G	A	17: 45,877,493 (GRCm39)	V207I	probably benign	Het
Sparcl1	T	G	5: 104,240,746 (GRCm39)	E226A	possibly damaging	Het
Srms	C	A	2: 180,851,302 (GRCm39)	A155S	possibly damaging	Het
Tas2r107	A	T	6: 131,636,917 (GRCm39)	I44N	probably damaging	Het
Tmem236	C	T	2: 14,224,132 (GRCm39)	T307M	probably damaging	Het
Ush2a	C	T	1: 188,679,155 (GRCm39)	P4788S	probably damaging	Het
Vmn1r170	A	T	7: 23,305,716 (GRCm39)	L39F	probably benign	Het
Vmn2r90	T	A	17: 17,947,122 (GRCm39)	*121R	probably null	Het

Other mutations in Or5w10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02122:Or5w10	APN	2	87,375,447 (GRCm39)	missense	probably benign	0.00
IGL02638:Or5w10	APN	2	87,375,093 (GRCm39)	missense	probably damaging	1.00
R1650:Or5w10	UTSW	2	87,375,772 (GRCm39)	missense	probably benign	0.01
R1789:Or5w10	UTSW	2	87,375,327 (GRCm39)	missense	probably damaging	1.00
R2100:Or5w10	UTSW	2	87,375,169 (GRCm39)	missense	probably damaging	1.00
R2163:Or5w10	UTSW	2	87,375,238 (GRCm39)	missense	probably damaging	1.00
R3950:Or5w10	UTSW	2	87,375,409 (GRCm39)	missense	probably damaging	1.00
R3951:Or5w10	UTSW	2	87,375,409 (GRCm39)	missense	probably damaging	1.00
R3952:Or5w10	UTSW	2	87,375,409 (GRCm39)	missense	probably damaging	1.00
R6185:Or5w10	UTSW	2	87,375,087 (GRCm39)	missense	possibly damaging	0.87
R8493:Or5w10	UTSW	2	87,375,114 (GRCm39)	missense	probably damaging	1.00
R8869:Or5w10	UTSW	2	87,375,753 (GRCm39)	missense	probably damaging	1.00
Z1176:Or5w10	UTSW	2	87,374,965 (GRCm39)	missense	probably benign	0.00

Posted On

2015-04-16