Incidental Mutation 'IGL02751:Tas2r104'
ID306290
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tas2r104
Ensembl Gene ENSMUSG00000061977
Gene Nametaste receptor, type 2, member 104
SynonymsT2R04, mGR04, Tas2r4, mt2r45
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.059) question?
Stock #IGL02751
Quality Score
Status
Chromosome6
Chromosomal Location131684836-131685744 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 131685144 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 201 (S201P)
Ref Sequence ENSEMBL: ENSMUSP00000072237 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053652] [ENSMUST00000072404] [ENSMUST00000080619]
Predicted Effect probably benign
Transcript: ENSMUST00000053652
SMART Domains Protein: ENSMUSP00000058006
Gene: ENSMUSG00000051153

DomainStartEndE-ValueType
Pfam:TAS2R 1 298 9.4e-109 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000072404
AA Change: S201P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000072237
Gene: ENSMUSG00000061977
AA Change: S201P

DomainStartEndE-ValueType
Pfam:TAS2R 1 298 8.3e-102 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000080619
SMART Domains Protein: ENSMUSP00000079453
Gene: ENSMUSG00000063478

DomainStartEndE-ValueType
Pfam:TAS2R 1 298 8.1e-104 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adra1a A T 14: 66,727,532 I324F possibly damaging Het
Ago2 G A 15: 73,130,897 A162V possibly damaging Het
Aox4 G T 1: 58,259,052 R1059I probably damaging Het
AU021092 C A 16: 5,212,619 V304L probably damaging Het
Bcs1l T G 1: 74,589,616 F20V probably damaging Het
Braf T C 6: 39,660,867 probably benign Het
Cacna1a T C 8: 84,569,952 C1200R probably damaging Het
Ccdc116 T A 16: 17,141,972 R284S probably benign Het
Cntnap5a T G 1: 116,184,457 probably null Het
Col12a1 A T 9: 79,613,859 probably benign Het
Cpa4 T A 6: 30,581,740 Y229N probably damaging Het
Fbp1 A C 13: 62,875,143 probably null Het
Gimap3 A T 6: 48,765,238 W253R probably benign Het
Gm1330 G A 2: 148,990,473 probably benign Het
Gm4841 A G 18: 60,271,021 probably benign Het
Grip1 A G 10: 119,978,577 T338A probably benign Het
Hmg20b A T 10: 81,346,551 probably benign Het
Hnrnpdl A G 5: 100,037,974 F151L probably damaging Het
Klhl30 T A 1: 91,354,099 F141I probably damaging Het
Lamc3 T A 2: 31,920,704 F862Y probably benign Het
Lap3 T C 5: 45,504,796 C313R probably damaging Het
Lrp2 T C 2: 69,533,462 T344A possibly damaging Het
Mga A G 2: 119,947,770 E2023G possibly damaging Het
Mical2 A T 7: 112,332,036 K735N probably benign Het
Muc15 A G 2: 110,731,773 T185A probably benign Het
Olfr109 T C 17: 37,466,415 C70R probably damaging Het
Osbp2 T C 11: 3,863,434 K145R probably benign Het
Pde1c T C 6: 56,181,688 T52A probably damaging Het
Pidd1 A G 7: 141,439,163 S802P possibly damaging Het
Pip5k1c C A 10: 81,317,321 probably null Het
Prep T A 10: 45,115,186 I316N probably damaging Het
Prl3d2 G A 13: 27,126,031 probably null Het
Pygo1 A T 9: 72,945,037 I169F probably benign Het
Rnf10 G T 5: 115,242,666 A716E probably benign Het
Rtn4 G A 11: 29,706,409 probably null Het
Ryr1 A T 7: 29,078,774 V2099E probably damaging Het
Slc48a1 G A 15: 97,790,080 probably benign Het
Spag17 T A 3: 100,010,794 Y364* probably null Het
Syt3 A T 7: 44,386,062 D31V possibly damaging Het
Tango2 G T 16: 18,307,993 P143H probably benign Het
Tas2r107 G A 6: 131,659,484 L201F probably damaging Het
Vmn1r81 A T 7: 12,260,447 L78Q probably damaging Het
Vmn2r18 T A 5: 151,584,607 T351S probably benign Het
Other mutations in Tas2r104
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00590:Tas2r104 APN 6 131685567 missense probably damaging 1.00
IGL01390:Tas2r104 APN 6 131685485 missense probably benign 0.13
PIT4585001:Tas2r104 UTSW 6 131685558 missense possibly damaging 0.50
R0218:Tas2r104 UTSW 6 131685092 missense probably damaging 1.00
R0453:Tas2r104 UTSW 6 131685341 missense probably benign 0.00
R0472:Tas2r104 UTSW 6 131685471 missense probably benign 0.06
R0614:Tas2r104 UTSW 6 131685202 missense probably damaging 1.00
R1290:Tas2r104 UTSW 6 131684845 nonsense probably null
R1480:Tas2r104 UTSW 6 131685294 missense probably benign 0.17
R1698:Tas2r104 UTSW 6 131685584 missense probably damaging 1.00
R2050:Tas2r104 UTSW 6 131685120 missense probably damaging 1.00
R2229:Tas2r104 UTSW 6 131685132 missense probably damaging 1.00
R3824:Tas2r104 UTSW 6 131685039 missense possibly damaging 0.55
R3852:Tas2r104 UTSW 6 131684925 missense probably benign 0.09
R4283:Tas2r104 UTSW 6 131685411 missense probably damaging 1.00
R4583:Tas2r104 UTSW 6 131685435 missense probably benign 0.00
R4710:Tas2r104 UTSW 6 131685444 missense probably damaging 0.96
R4954:Tas2r104 UTSW 6 131685005 missense probably damaging 0.99
R5559:Tas2r104 UTSW 6 131685131 missense probably damaging 1.00
R5765:Tas2r104 UTSW 6 131685273 missense probably benign
R5843:Tas2r104 UTSW 6 131684975 missense probably damaging 0.99
R7304:Tas2r104 UTSW 6 131685042 missense possibly damaging 0.90
Posted On2015-04-16