Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02751:Tas2r104'

306290

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tas2r104

Ensembl Gene

ENSMUSG00000061977

Gene Name

taste receptor, type 2, member 104

Synonyms

mt2r45, Tas2r4, mGR04, T2R04

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.052) question?

Stock #

IGL02751

Quality Score

Status

Chromosome

Chromosomal Location

131661799-131662707 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 131662107 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 201 (S201P)

Ref Sequence

ENSEMBL: ENSMUSP00000072237 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000053652] [ENSMUST00000072404] [ENSMUST00000080619]

AlphaFold

Q7M723

Predicted Effect

probably benign
Transcript: ENSMUST00000053652

SMART Domains

Protein: ENSMUSP00000058006
Gene: ENSMUSG00000051153

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	298	9.4e-109	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000072404
AA Change: S201P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000072237
Gene: ENSMUSG00000061977
AA Change: S201P

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	298	8.3e-102	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000080619

SMART Domains

Protein: ENSMUSP00000079453
Gene: ENSMUSG00000063478

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	298	8.1e-104	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adra1a	A	T	14: 66,964,981 (GRCm39)	I324F	possibly damaging	Het
Ago2	G	A	15: 73,002,746 (GRCm39)	A162V	possibly damaging	Het
Aox4	G	T	1: 58,298,211 (GRCm39)	R1059I	probably damaging	Het
AU021092	C	A	16: 5,030,483 (GRCm39)	V304L	probably damaging	Het
Bcs1l	T	G	1: 74,628,775 (GRCm39)	F20V	probably damaging	Het
Braf	T	C	6: 39,637,801 (GRCm39)		probably benign	Het
Cacna1a	T	C	8: 85,296,581 (GRCm39)	C1200R	probably damaging	Het
Ccdc116	T	A	16: 16,959,836 (GRCm39)	R284S	probably benign	Het
Cntnap5a	T	G	1: 116,112,187 (GRCm39)		probably null	Het
Col12a1	A	T	9: 79,521,141 (GRCm39)		probably benign	Het
Cpa4	T	A	6: 30,581,739 (GRCm39)	Y229N	probably damaging	Het
Fbp1	A	C	13: 63,022,957 (GRCm39)		probably null	Het
Gimap3	A	T	6: 48,742,172 (GRCm39)	W253R	probably benign	Het
Gm1330	G	A	2: 148,832,393 (GRCm39)		probably benign	Het
Gm4841	A	G	18: 60,404,093 (GRCm39)		probably benign	Het
Grip1	A	G	10: 119,814,482 (GRCm39)	T338A	probably benign	Het
Hmg20b	A	T	10: 81,182,385 (GRCm39)		probably benign	Het
Hnrnpdl	A	G	5: 100,185,833 (GRCm39)	F151L	probably damaging	Het
Klhl30	T	A	1: 91,281,821 (GRCm39)	F141I	probably damaging	Het
Lamc3	T	A	2: 31,810,716 (GRCm39)	F862Y	probably benign	Het
Lap3	T	C	5: 45,662,138 (GRCm39)	C313R	probably damaging	Het
Lrp2	T	C	2: 69,363,806 (GRCm39)	T344A	possibly damaging	Het
Mga	A	G	2: 119,778,251 (GRCm39)	E2023G	possibly damaging	Het
Mical2	A	T	7: 111,931,243 (GRCm39)	K735N	probably benign	Het
Muc15	A	G	2: 110,562,118 (GRCm39)	T185A	probably benign	Het
Or12d17	T	C	17: 37,777,306 (GRCm39)	C70R	probably damaging	Het
Osbp2	T	C	11: 3,813,434 (GRCm39)	K145R	probably benign	Het
Pde1c	T	C	6: 56,158,673 (GRCm39)	T52A	probably damaging	Het
Pidd1	A	G	7: 141,019,076 (GRCm39)	S802P	possibly damaging	Het
Pip5k1c	C	A	10: 81,153,155 (GRCm39)		probably null	Het
Prep	T	A	10: 44,991,282 (GRCm39)	I316N	probably damaging	Het
Prl3d2	G	A	13: 27,310,014 (GRCm39)		probably null	Het
Pygo1	A	T	9: 72,852,319 (GRCm39)	I169F	probably benign	Het
Rnf10	G	T	5: 115,380,725 (GRCm39)	A716E	probably benign	Het
Rtn4	G	A	11: 29,656,409 (GRCm39)		probably null	Het
Ryr1	A	T	7: 28,778,199 (GRCm39)	V2099E	probably damaging	Het
Slc48a1	G	A	15: 97,687,961 (GRCm39)		probably benign	Het
Spag17	T	A	3: 99,918,110 (GRCm39)	Y364*	probably null	Het
Syt3	A	T	7: 44,035,486 (GRCm39)	D31V	possibly damaging	Het
Tango2	G	T	16: 18,125,857 (GRCm39)	P143H	probably benign	Het
Tas2r107	G	A	6: 131,636,447 (GRCm39)	L201F	probably damaging	Het
Vmn1r81	A	T	7: 11,994,374 (GRCm39)	L78Q	probably damaging	Het
Vmn2r18	T	A	5: 151,508,072 (GRCm39)	T351S	probably benign	Het

Other mutations in Tas2r104

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00590:Tas2r104	APN	6	131,662,530 (GRCm39)	missense	probably damaging	1.00
IGL01390:Tas2r104	APN	6	131,662,448 (GRCm39)	missense	probably benign	0.13
PIT4585001:Tas2r104	UTSW	6	131,662,521 (GRCm39)	missense	possibly damaging	0.50
R0218:Tas2r104	UTSW	6	131,662,055 (GRCm39)	missense	probably damaging	1.00
R0453:Tas2r104	UTSW	6	131,662,304 (GRCm39)	missense	probably benign	0.00
R0472:Tas2r104	UTSW	6	131,662,434 (GRCm39)	missense	probably benign	0.06
R0614:Tas2r104	UTSW	6	131,662,165 (GRCm39)	missense	probably damaging	1.00
R1290:Tas2r104	UTSW	6	131,661,808 (GRCm39)	nonsense	probably null
R1480:Tas2r104	UTSW	6	131,662,257 (GRCm39)	missense	probably benign	0.17
R1698:Tas2r104	UTSW	6	131,662,547 (GRCm39)	missense	probably damaging	1.00
R2050:Tas2r104	UTSW	6	131,662,083 (GRCm39)	missense	probably damaging	1.00
R2229:Tas2r104	UTSW	6	131,662,095 (GRCm39)	missense	probably damaging	1.00
R3824:Tas2r104	UTSW	6	131,662,002 (GRCm39)	missense	possibly damaging	0.55
R3852:Tas2r104	UTSW	6	131,661,888 (GRCm39)	missense	probably benign	0.09
R4283:Tas2r104	UTSW	6	131,662,374 (GRCm39)	missense	probably damaging	1.00
R4583:Tas2r104	UTSW	6	131,662,398 (GRCm39)	missense	probably benign	0.00
R4710:Tas2r104	UTSW	6	131,662,407 (GRCm39)	missense	probably damaging	0.96
R4954:Tas2r104	UTSW	6	131,661,968 (GRCm39)	missense	probably damaging	0.99
R5559:Tas2r104	UTSW	6	131,662,094 (GRCm39)	missense	probably damaging	1.00
R5765:Tas2r104	UTSW	6	131,662,236 (GRCm39)	missense	probably benign
R5843:Tas2r104	UTSW	6	131,661,938 (GRCm39)	missense	probably damaging	0.99
R7304:Tas2r104	UTSW	6	131,662,005 (GRCm39)	missense	possibly damaging	0.90
R8559:Tas2r104	UTSW	6	131,662,388 (GRCm39)	missense	probably damaging	1.00
R8864:Tas2r104	UTSW	6	131,662,632 (GRCm39)	missense	possibly damaging	0.95
R8951:Tas2r104	UTSW	6	131,662,569 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16