Incidental Mutation 'IGL00095:Mrgpra9'
| ID |
306538 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Mrgpra9
|
| Ensembl Gene |
ENSMUSG00000074111 |
| Gene Name |
MAS-related GPR, member A9 |
| Synonyms |
MrgA9, EG668725 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.050)
|
| Stock # |
IGL00095
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
46884667-46902627 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 46884839 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 276
(V276A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000136396
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000098436]
[ENSMUST00000179005]
|
| AlphaFold |
A0A140T8U8 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000098436
AA Change: V275A
PolyPhen 2
Score 0.846 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000096035
Gene: ENSMUSG00000074111
AA Change: V275A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
37 |
48 |
N/A |
INTRINSIC |
|
Pfam:7tm_1
|
56 |
225 |
1.5e-11 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000179005
AA Change: V276A
PolyPhen 2
Score 0.846 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000136396
Gene: ENSMUSG00000074111
AA Change: V276A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_1
|
12 |
178 |
3.4e-9 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 38 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Cadm2 |
A |
T |
16: 66,679,639 (GRCm39) |
Y65N |
probably damaging |
Het |
| Catsperg2 |
C |
A |
7: 29,397,483 (GRCm39) |
C1042F |
possibly damaging |
Het |
| Cluh |
T |
C |
11: 74,554,890 (GRCm39) |
V776A |
probably benign |
Het |
| Crxos |
T |
A |
7: 15,632,543 (GRCm39) |
C116* |
probably null |
Het |
| Csmd1 |
A |
G |
8: 16,059,297 (GRCm39) |
|
probably benign |
Het |
| Cubn |
C |
A |
2: 13,496,631 (GRCm39) |
|
probably benign |
Het |
| Exoc2 |
A |
G |
13: 31,004,609 (GRCm39) |
I858T |
probably benign |
Het |
| Frmpd1 |
C |
A |
4: 45,279,456 (GRCm39) |
T727K |
possibly damaging |
Het |
| Hapln3 |
T |
C |
7: 78,771,731 (GRCm39) |
T53A |
probably damaging |
Het |
| Hnrnpul1 |
T |
A |
7: 25,425,579 (GRCm39) |
Q584L |
possibly damaging |
Het |
| Ikbkb |
A |
T |
8: 23,196,127 (GRCm39) |
F26I |
probably damaging |
Het |
| Il31ra |
A |
T |
13: 112,684,012 (GRCm39) |
I120N |
possibly damaging |
Het |
| Itih1 |
C |
T |
14: 30,651,778 (GRCm39) |
V855M |
probably benign |
Het |
| Krtap4-16 |
A |
G |
11: 99,742,032 (GRCm39) |
S123P |
possibly damaging |
Het |
| Large1 |
C |
T |
8: 73,564,125 (GRCm39) |
R547Q |
probably damaging |
Het |
| Madd |
A |
G |
2: 91,006,111 (GRCm39) |
|
probably benign |
Het |
| Mark1 |
A |
G |
1: 184,630,800 (GRCm39) |
V770A |
probably damaging |
Het |
| Mpeg1 |
T |
C |
19: 12,440,074 (GRCm39) |
F511L |
probably benign |
Het |
| Nav3 |
T |
C |
10: 109,677,594 (GRCm39) |
T666A |
probably damaging |
Het |
| Ndufa8 |
T |
C |
2: 35,934,467 (GRCm39) |
D37G |
probably damaging |
Het |
| Nlrx1 |
A |
G |
9: 44,164,576 (GRCm39) |
L956P |
probably damaging |
Het |
| Nr5a1 |
T |
C |
2: 38,598,353 (GRCm39) |
E148G |
probably benign |
Het |
| Or10ab5 |
A |
T |
7: 108,245,043 (GRCm39) |
F247I |
possibly damaging |
Het |
| Or14c46 |
T |
C |
7: 85,918,877 (GRCm39) |
N40S |
probably damaging |
Het |
| Otulinl |
A |
G |
15: 27,658,202 (GRCm39) |
S273P |
possibly damaging |
Het |
| Patj |
A |
C |
4: 98,423,799 (GRCm39) |
Q1184P |
possibly damaging |
Het |
| Phf20l1 |
A |
G |
15: 66,500,884 (GRCm39) |
T619A |
probably benign |
Het |
| Pla2g6 |
T |
C |
15: 79,173,441 (GRCm39) |
T643A |
probably damaging |
Het |
| Pramel42 |
T |
C |
5: 94,685,663 (GRCm39) |
L441P |
probably damaging |
Het |
| Radil |
A |
G |
5: 142,483,677 (GRCm39) |
S510P |
probably damaging |
Het |
| Spock1 |
A |
G |
13: 57,735,552 (GRCm39) |
|
probably benign |
Het |
| Stag3 |
C |
T |
5: 138,297,400 (GRCm39) |
T577M |
probably damaging |
Het |
| Tap2 |
C |
T |
17: 34,434,352 (GRCm39) |
R613C |
probably benign |
Het |
| Tnn |
A |
G |
1: 159,953,021 (GRCm39) |
V673A |
possibly damaging |
Het |
| Trrap |
T |
C |
5: 144,716,784 (GRCm39) |
|
probably benign |
Het |
| Vmn2r28 |
T |
C |
7: 5,491,068 (GRCm39) |
D393G |
probably benign |
Het |
| Zbtb48 |
T |
C |
4: 152,105,851 (GRCm39) |
H418R |
probably damaging |
Het |
| Zc3h12d |
T |
C |
10: 7,738,231 (GRCm39) |
V179A |
probably damaging |
Het |
|
| Other mutations in Mrgpra9 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00575:Mrgpra9
|
APN |
7 |
46,885,053 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
IGL01649:Mrgpra9
|
APN |
7 |
46,884,900 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL03207:Mrgpra9
|
APN |
7 |
46,885,385 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R0388:Mrgpra9
|
UTSW |
7 |
46,902,542 (GRCm39) |
start codon destroyed |
probably null |
0.08 |
|
R0972:Mrgpra9
|
UTSW |
7 |
46,885,203 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1270:Mrgpra9
|
UTSW |
7 |
46,902,531 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1381:Mrgpra9
|
UTSW |
7 |
46,885,050 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R1403:Mrgpra9
|
UTSW |
7 |
46,885,386 (GRCm39) |
missense |
probably benign |
0.24 |
|
R1403:Mrgpra9
|
UTSW |
7 |
46,885,386 (GRCm39) |
missense |
probably benign |
0.24 |
|
R1448:Mrgpra9
|
UTSW |
7 |
46,885,561 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2045:Mrgpra9
|
UTSW |
7 |
46,885,583 (GRCm39) |
missense |
probably benign |
|
|
R2144:Mrgpra9
|
UTSW |
7 |
46,885,211 (GRCm39) |
missense |
probably benign |
0.31 |
|
R2187:Mrgpra9
|
UTSW |
7 |
46,884,797 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2507:Mrgpra9
|
UTSW |
7 |
46,885,242 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R2913:Mrgpra9
|
UTSW |
7 |
46,884,828 (GRCm39) |
missense |
probably benign |
|
|
R3810:Mrgpra9
|
UTSW |
7 |
46,885,527 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4177:Mrgpra9
|
UTSW |
7 |
46,885,302 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4521:Mrgpra9
|
UTSW |
7 |
46,884,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4781:Mrgpra9
|
UTSW |
7 |
46,884,795 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4926:Mrgpra9
|
UTSW |
7 |
46,884,759 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R6469:Mrgpra9
|
UTSW |
7 |
46,884,854 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6505:Mrgpra9
|
UTSW |
7 |
46,884,884 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6724:Mrgpra9
|
UTSW |
7 |
46,884,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7398:Mrgpra9
|
UTSW |
7 |
46,885,385 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R8737:Mrgpra9
|
UTSW |
7 |
46,885,624 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8824:Mrgpra9
|
UTSW |
7 |
46,885,041 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8881:Mrgpra9
|
UTSW |
7 |
46,885,242 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R9320:Mrgpra9
|
UTSW |
7 |
46,885,392 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Posted On |
2015-04-16 |
Incidental Mutation