Incidental Mutation 'IGL00961:Gm21759'
ID306597
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm21759
Ensembl Gene ENSMUSG00000094226
Gene Namepredicted gene, 21759
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.210) question?
Stock #IGL00961
Quality Score
Status
Chromosome5
Chromosomal Location8179636-8181453 bp(+) (GRCm38)
Type of Mutationintron
DNA Base Change (assembly) A to T at 8179731 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000111046 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046838] [ENSMUST00000050166] [ENSMUST00000088744] [ENSMUST00000088761] [ENSMUST00000115385] [ENSMUST00000115386] [ENSMUST00000115388]
Predicted Effect probably benign
Transcript: ENSMUST00000046838
SMART Domains Protein: ENSMUSP00000049120
Gene: ENSMUSG00000040537

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:Pep_M12B_propep 44 186 7e-27 PFAM
low complexity region 214 230 N/A INTRINSIC
Pfam:Reprolysin_5 235 405 9.3e-9 PFAM
Pfam:Reprolysin 237 436 1.1e-58 PFAM
Pfam:Reprolysin_3 261 379 3e-12 PFAM
DISIN 451 527 3.38e-31 SMART
ACR 528 669 3.05e-58 SMART
EGF 676 710 1.28e1 SMART
transmembrane domain 735 757 N/A INTRINSIC
low complexity region 789 808 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000050166
SMART Domains Protein: ENSMUSP00000055000
Gene: ENSMUSG00000040537

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:Pep_M12B_propep 44 186 7.6e-27 PFAM
low complexity region 214 230 N/A INTRINSIC
Pfam:Reprolysin_5 235 405 1.1e-8 PFAM
Pfam:Reprolysin 237 436 1.1e-58 PFAM
Pfam:Reprolysin_3 261 379 3.4e-12 PFAM
DISIN 451 527 3.38e-31 SMART
ACR 528 669 3.05e-58 SMART
EGF 676 710 1.28e1 SMART
transmembrane domain 735 757 N/A INTRINSIC
low complexity region 824 839 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000088744
SMART Domains Protein: ENSMUSP00000086122
Gene: ENSMUSG00000040537

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:Pep_M12B_propep 41 186 4.2e-29 PFAM
low complexity region 214 230 N/A INTRINSIC
Pfam:Reprolysin_5 235 405 1.2e-8 PFAM
Pfam:Reprolysin 237 436 2.9e-65 PFAM
Pfam:Reprolysin_3 261 378 9.2e-13 PFAM
DISIN 451 527 3.38e-31 SMART
ACR 528 669 3.05e-58 SMART
EGF 676 710 1.28e1 SMART
transmembrane domain 736 758 N/A INTRINSIC
low complexity region 785 800 N/A INTRINSIC
low complexity region 883 898 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000088761
SMART Domains Protein: ENSMUSP00000086139
Gene: ENSMUSG00000040537

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:Pep_M12B_propep 44 186 8.1e-27 PFAM
low complexity region 214 230 N/A INTRINSIC
Pfam:Reprolysin_5 235 405 1.2e-8 PFAM
Pfam:Reprolysin 237 436 1.1e-58 PFAM
Pfam:Reprolysin_3 261 379 3.6e-12 PFAM
DISIN 451 527 3.38e-31 SMART
ACR 528 669 3.05e-58 SMART
EGF 676 710 1.28e1 SMART
transmembrane domain 735 757 N/A INTRINSIC
low complexity region 789 808 N/A INTRINSIC
low complexity region 860 875 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000115385
SMART Domains Protein: ENSMUSP00000111043
Gene: ENSMUSG00000040537

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:Pep_M12B_propep 40 186 5.2e-28 PFAM
low complexity region 214 230 N/A INTRINSIC
Pfam:Reprolysin 237 333 2e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000115386
SMART Domains Protein: ENSMUSP00000111044
Gene: ENSMUSG00000040537

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:Pep_M12B_propep 44 186 3.4e-27 PFAM
low complexity region 214 230 N/A INTRINSIC
Pfam:Reprolysin_5 235 405 5.1e-9 PFAM
Pfam:Reprolysin 237 436 5e-59 PFAM
Pfam:Reprolysin_3 261 379 1.6e-12 PFAM
DISIN 451 527 3.38e-31 SMART
ACR 528 669 3.05e-58 SMART
EGF 676 710 1.28e1 SMART
transmembrane domain 735 757 N/A INTRINSIC
low complexity region 850 870 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000115388
SMART Domains Protein: ENSMUSP00000111046
Gene: ENSMUSG00000040537

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:Pep_M12B_propep 44 186 8e-27 PFAM
low complexity region 214 230 N/A INTRINSIC
Pfam:Reprolysin_5 235 405 1.1e-8 PFAM
Pfam:Reprolysin 237 436 1.1e-58 PFAM
Pfam:Reprolysin_3 261 379 3.5e-12 PFAM
DISIN 451 527 3.38e-31 SMART
ACR 528 669 3.05e-58 SMART
EGF 676 710 1.28e1 SMART
transmembrane domain 735 757 N/A INTRINSIC
low complexity region 852 872 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000178345
SMART Domains Protein: ENSMUSP00000136133
Gene: ENSMUSG00000094226

DomainStartEndE-ValueType
S_TKc 24 271 1.67e-93 SMART
low complexity region 325 339 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921522P10Rik C A 8: 8,663,425 probably benign Het
Arfgef3 T A 10: 18,611,237 I1350F probably damaging Het
Arfip1 A G 3: 84,497,788 V236A probably benign Het
Bicc1 A G 10: 70,961,157 I124T probably damaging Het
Cacnb4 T A 2: 52,477,712 I82F possibly damaging Het
Card11 A T 5: 140,899,709 M365K probably damaging Het
Chd2 A G 7: 73,444,249 S1560P probably damaging Het
Depdc1a T A 3: 159,523,814 N594K possibly damaging Het
Dmbx1 A T 4: 115,920,006 V215E probably benign Het
Farp2 A T 1: 93,621,313 E1047V possibly damaging Het
Gpr182 C T 10: 127,750,690 V131I probably benign Het
Irx1 T C 13: 71,959,957 D202G probably damaging Het
Lrp6 T C 6: 134,507,646 D338G probably damaging Het
Nrxn3 A T 12: 90,204,546 I241L possibly damaging Het
Parp6 A G 9: 59,632,959 Y265C probably damaging Het
Prex1 G T 2: 166,585,736 Q999K probably damaging Het
Rad54b T C 4: 11,599,699 I301T probably damaging Het
Rnf213 A T 11: 119,440,843 I2294F possibly damaging Het
Ska3 T C 14: 57,822,124 I81M possibly damaging Het
Smap1 T C 1: 23,848,274 N308S probably benign Het
Stag3 A G 5: 138,298,349 K490E probably benign Het
Stk11ip C T 1: 75,530,266 R664C probably damaging Het
Tmem176b T A 6: 48,834,070 I259F possibly damaging Het
Usp37 T C 1: 74,490,155 T122A probably benign Het
Vmn2r7 T C 3: 64,715,813 E453G possibly damaging Het
Other mutations in Gm21759
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01621:Gm21759 APN 5 8179775 intron probably benign
IGL01939:Gm21759 APN 5 8180685 intron probably benign
IGL01984:Gm21759 APN 5 8180547 intron probably benign
IGL02262:Gm21759 APN 5 8180747 intron probably benign
IGL02525:Gm21759 APN 5 8179967 intron probably benign
R2870:Gm21759 UTSW 5 8180863 intron probably benign
R2871:Gm21759 UTSW 5 8180863 intron probably benign
R2872:Gm21759 UTSW 5 8180863 intron probably benign
Posted On2015-04-16