Incidental Mutation 'IGL00962:Gm6665'
ID306598
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm6665
Ensembl Gene ENSMUSG00000091561
Gene Namepredicted gene 6665
Synonyms
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL00962
Quality Score
Status
Chromosome18
Chromosomal Location31819862-31820413 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 31820151 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Arginine at position 57 (K57R)
Ref Sequence ENSEMBL: ENSMUSP00000129853 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025264] [ENSMUST00000082319] [ENSMUST00000165131]
Predicted Effect probably benign
Transcript: ENSMUST00000025264
SMART Domains Protein: ENSMUSP00000025264
Gene: ENSMUSG00000024400

DomainStartEndE-ValueType
WD40 107 147 2.15e-1 SMART
WD40 150 189 5.77e-5 SMART
WD40 191 230 1.89e-9 SMART
WD40 233 274 2.59e-7 SMART
WD40 277 316 2.73e-6 SMART
WD40 320 360 1.71e-7 SMART
WD40 364 403 1.52e-4 SMART
low complexity region 481 499 N/A INTRINSIC
coiled coil region 531 559 N/A INTRINSIC
low complexity region 573 587 N/A INTRINSIC
low complexity region 608 624 N/A INTRINSIC
low complexity region 628 668 N/A INTRINSIC
low complexity region 679 722 N/A INTRINSIC
low complexity region 725 761 N/A INTRINSIC
internal_repeat_1 778 803 3.47e-9 PROSPERO
low complexity region 806 818 N/A INTRINSIC
internal_repeat_1 821 845 3.47e-9 PROSPERO
low complexity region 848 881 N/A INTRINSIC
low complexity region 920 935 N/A INTRINSIC
low complexity region 938 951 N/A INTRINSIC
low complexity region 1000 1018 N/A INTRINSIC
low complexity region 1041 1049 N/A INTRINSIC
low complexity region 1057 1100 N/A INTRINSIC
low complexity region 1137 1154 N/A INTRINSIC
low complexity region 1190 1207 N/A INTRINSIC
low complexity region 1251 1262 N/A INTRINSIC
low complexity region 1287 1330 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000082319
SMART Domains Protein: ENSMUSP00000080936
Gene: ENSMUSG00000024400

DomainStartEndE-ValueType
WD40 107 147 2.15e-1 SMART
WD40 150 189 5.77e-5 SMART
WD40 191 230 1.89e-9 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000165131
AA Change: K57R

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000129853
Gene: ENSMUSG00000091561
AA Change: K57R

DomainStartEndE-ValueType
Pfam:GST_N 1 47 6.3e-12 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 21 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afg3l2 C T 18: 67,431,653 probably null Het
Atp8b1 C T 18: 64,531,444 A1218T probably damaging Het
AY761185 T C 8: 20,944,595 D39G possibly damaging Het
Fam167a G A 14: 63,462,455 E155K probably damaging Het
Fam35a A T 14: 34,249,251 V559E probably damaging Het
Fat3 C T 9: 15,915,519 G4379D probably benign Het
Fkbp10 A G 11: 100,421,817 T300A probably benign Het
Gnb4 T C 3: 32,593,169 T86A probably benign Het
H2-Q2 A G 17: 35,342,849 Y105C probably damaging Het
Ighv1-75 A G 12: 115,834,263 probably benign Het
Ilvbl A G 10: 78,583,338 T474A possibly damaging Het
Slc45a3 T A 1: 131,977,527 V96D probably damaging Het
Tmtc3 C T 10: 100,471,953 G201R probably damaging Het
Tnfsf14 G A 17: 57,192,906 Q83* probably null Het
Trpm2 A G 10: 77,943,916 probably benign Het
Ubr5 A T 15: 37,985,934 F2219I probably damaging Het
Utrn C T 10: 12,481,334 V2747I possibly damaging Het
Vcan T C 13: 89,662,052 N3207D probably damaging Het
Vmn1r35 A G 6: 66,679,377 V103A possibly damaging Het
Vmn2r97 A G 17: 18,929,228 T293A probably damaging Het
Wdr35 A G 12: 9,021,726 probably benign Het
Other mutations in Gm6665
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01873:Gm6665 APN 18 31820302 missense probably damaging 1.00
R1551:Gm6665 UTSW 18 31820287 missense probably damaging 0.99
R1797:Gm6665 UTSW 18 31820133 missense possibly damaging 0.49
R1922:Gm6665 UTSW 18 31820265 missense probably benign 0.11
R6123:Gm6665 UTSW 18 31819884 missense probably benign 0.00
Posted On2015-04-16