Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00969:Zfyve21'

306621

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfyve21

Ensembl Gene

ENSMUSG00000021286

Gene Name

zinc finger, FYVE domain containing 21

Synonyms

1110013H04Rik, C85416

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00969

Quality Score

Status

Chromosome

Chromosomal Location

111780600-111794822 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to G at 111791368 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000021714] [ENSMUST00000054815] [ENSMUST00000220486] [ENSMUST00000220616] [ENSMUST00000221375] [ENSMUST00000222843]

AlphaFold

Q8VCM3

Predicted Effect

probably benign
Transcript: ENSMUST00000021714

SMART Domains

Protein: ENSMUSP00000021714
Gene: ENSMUSG00000021286

Domain	Start	End	E-Value	Type
FYVE	36	105	7.11e-16	SMART
Pfam:ZFYVE21_C	108	233	1.1e-56	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000054815

SMART Domains

Protein: ENSMUSP00000062464
Gene: ENSMUSG00000021285

Domain	Start	End	E-Value	Type
PDB:2UWQ\|A	1	83	8e-35	PDB
Blast:RA	5	84	3e-47	BLAST
coiled coil region	123	305	N/A	INTRINSIC
low complexity region	437	476	N/A	INTRINSIC
low complexity region	523	539	N/A	INTRINSIC
low complexity region	610	625	N/A	INTRINSIC
PDB:4IRV\|H	695	741	1e-12	PDB
ANK	917	946	4.16e-7	SMART
ANK	950	979	4.63e-5	SMART
SH3	1019	1077	1.79e-18	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000220486

Predicted Effect

probably benign
Transcript: ENSMUST00000220616

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000221313

Predicted Effect

probably benign
Transcript: ENSMUST00000221375

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000221488

Predicted Effect

probably benign
Transcript: ENSMUST00000222843

Predicted Effect

probably benign
Transcript: ENSMUST00000223211

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akap9	G	A	5: 4,051,550 (GRCm39)	S1439N	probably benign	Het
Bcl9l	A	G	9: 44,419,539 (GRCm39)	T1069A	possibly damaging	Het
Btaf1	T	G	19: 36,988,652 (GRCm39)		probably benign	Het
Cdc40	A	T	10: 40,719,124 (GRCm39)	V335E	probably damaging	Het
Cenpj	A	T	14: 56,802,420 (GRCm39)	N48K	possibly damaging	Het
Cfh	A	G	1: 140,016,420 (GRCm39)	W635R	probably damaging	Het
Clca3a1	A	G	3: 144,714,719 (GRCm39)	S633P	possibly damaging	Het
Cnot6	T	C	11: 49,575,947 (GRCm39)	M176V	probably benign	Het
Cryz	G	T	3: 154,324,163 (GRCm39)	E51*	probably null	Het
Dcc	A	G	18: 71,589,954 (GRCm39)	Y681H	probably benign	Het
Dmxl1	T	A	18: 50,045,792 (GRCm39)	N2412K	probably benign	Het
Gpr137b	C	T	13: 13,539,650 (GRCm39)	W258*	probably null	Het
Hnf1b	A	G	11: 83,773,526 (GRCm39)	T242A	probably benign	Het
Hsd11b1	A	T	1: 192,905,952 (GRCm39)	C213*	probably null	Het
Igsf11	A	T	16: 38,829,279 (GRCm39)	T117S	probably damaging	Het
Inpp5b	T	C	4: 124,677,787 (GRCm39)	Y416H	probably damaging	Het
Kcnq3	C	A	15: 65,876,575 (GRCm39)	V523F	probably damaging	Het
Krtap9-5	T	C	11: 99,839,291 (GRCm39)		probably benign	Het
Lrig3	T	C	10: 125,832,984 (GRCm39)	L286S	probably damaging	Het
Myo18b	C	T	5: 113,022,873 (GRCm39)		probably benign	Het
Nup58	A	G	14: 60,466,365 (GRCm39)		probably benign	Het
Or51b6b	T	A	7: 103,310,274 (GRCm39)	Y61F	probably damaging	Het
Or5b94	T	C	19: 12,651,605 (GRCm39)	L12P	probably damaging	Het
Or5h18	A	G	16: 58,847,994 (GRCm39)	I92T	possibly damaging	Het
Or8k16	G	A	2: 85,520,007 (GRCm39)	C78Y	probably benign	Het
Pyroxd2	T	C	19: 42,719,877 (GRCm39)	D443G	possibly damaging	Het
Ttc28	A	G	5: 111,373,606 (GRCm39)	D1014G	probably benign	Het
Tubgcp5	T	A	7: 55,456,343 (GRCm39)	S312T	possibly damaging	Het
Uckl1	T	C	2: 181,211,410 (GRCm39)	D473G	probably benign	Het
Vmn2r76	G	T	7: 85,877,925 (GRCm39)	H491N	probably benign	Het
Wwc2	G	A	8: 48,299,193 (GRCm39)	R1039W	unknown	Het
Zc3h14	T	A	12: 98,725,102 (GRCm39)	S255T	probably benign	Het
Zfp369	T	C	13: 65,445,074 (GRCm39)	V739A	probably benign	Het
Znhit6	A	G	3: 145,300,351 (GRCm39)		probably benign	Het

Other mutations in Zfyve21

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01618:Zfyve21	APN	12	111,794,247 (GRCm39)	splice site	probably benign
IGL02729:Zfyve21	APN	12	111,791,485 (GRCm39)	missense	probably benign	0.01
R0513:Zfyve21	UTSW	12	111,789,698 (GRCm39)	missense	possibly damaging	0.65
R1813:Zfyve21	UTSW	12	111,791,328 (GRCm39)	missense	probably damaging	0.99
R6351:Zfyve21	UTSW	12	111,794,028 (GRCm39)	missense	probably benign	0.01
R7355:Zfyve21	UTSW	12	111,791,485 (GRCm39)	missense	possibly damaging	0.94
R7514:Zfyve21	UTSW	12	111,790,249 (GRCm39)	missense	probably damaging	1.00
R8314:Zfyve21	UTSW	12	111,789,715 (GRCm39)	missense	probably benign	0.07
T0975:Zfyve21	UTSW	12	111,794,067 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16