Incidental Mutation 'R3917:Or8b37'
ID 307353
Institutional Source Beutler Lab
Gene Symbol Or8b37
Ensembl Gene ENSMUSG00000095893
Gene Name olfactory receptor family 8 subfamily B member 37
Synonyms GA_x6K02T2PVTD-31726544-31727473, MOR162-9P, MOR162-11P, Olfr1550-ps1, MOR162-13, Olfr884, MOR162-11P
MMRRC Submission 040914-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # R3917 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 37957851-37961433 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 37958841 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 108 (I108F)
Ref Sequence ENSEMBL: ENSMUSP00000138035 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077732] [ENSMUST00000181088]
AlphaFold Q7TRE1
Predicted Effect probably damaging
Transcript: ENSMUST00000077732
AA Change: I108F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000076912
Gene: ENSMUSG00000095893
AA Change: I108F

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 8e-51 PFAM
Pfam:7TM_GPCR_Srsx 35 300 1.5e-6 PFAM
Pfam:7tm_1 41 288 5.1e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000181088
AA Change: I108F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000138035
Gene: ENSMUSG00000095893
AA Change: I108F

DomainStartEndE-ValueType
low complexity region 14 33 N/A INTRINSIC
Pfam:7TM_GPCR_Srsx 35 300 1.5e-6 PFAM
Pfam:7tm_1 41 288 4.6e-30 PFAM
Pfam:7tm_4 138 281 3.9e-45 PFAM
Meta Mutation Damage Score 0.5137 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency 97% (74/76)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acad12 A G 5: 121,737,277 (GRCm39) V498A probably damaging Het
Adam19 A G 11: 45,951,762 (GRCm39) E37G probably benign Het
Apol11b A G 15: 77,519,504 (GRCm39) I192T probably benign Het
Appl1 A T 14: 26,650,561 (GRCm39) F537Y probably damaging Het
Atad5 A C 11: 79,994,120 (GRCm39) K785N probably null Het
Atp1b2 A G 11: 69,493,901 (GRCm39) V93A probably damaging Het
Bcam T C 7: 19,499,375 (GRCm39) Y216C probably damaging Het
Brca2 A G 5: 150,464,292 (GRCm39) E1352G probably damaging Het
C030005K15Rik A C 10: 97,561,453 (GRCm39) S93A unknown Het
Cadps C T 14: 12,457,702 (GRCm38) A1060T probably benign Het
Ccdc88c A G 12: 100,907,366 (GRCm39) probably null Het
Ccdc89 A G 7: 90,076,033 (GRCm39) D81G probably damaging Het
Ccnt1 A G 15: 98,441,940 (GRCm39) S443P probably benign Het
Cd109 CATTTATTTATTTATTTATTTATTTATTTATTTAT CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT 9: 78,619,782 (GRCm39) probably benign Het
Cdc42bpa T C 1: 179,933,719 (GRCm39) probably null Het
Cdk11b T C 4: 155,711,258 (GRCm39) S47P probably damaging Het
Cfap43 T C 19: 47,886,189 (GRCm39) D142G probably benign Het
Cntnap4 C G 8: 113,602,165 (GRCm39) P1190A probably benign Het
Colgalt2 T A 1: 152,384,362 (GRCm39) Y567* probably null Het
Dner CGCTGCTGCTGCTGCTGCTGCTGCTGC CGCTGCTGCTGCTGCTGCTGCTGC 1: 84,563,270 (GRCm39) probably benign Het
Dock7 T C 4: 98,904,922 (GRCm39) Y651C probably damaging Het
Fzd3 A T 14: 65,473,379 (GRCm39) F130I probably damaging Het
Gabarapl2 T A 8: 112,679,028 (GRCm39) F115L probably benign Het
Gm1043 G A 5: 37,350,285 (GRCm39) probably benign Het
Gm12185 A G 11: 48,806,760 (GRCm39) F144L probably benign Het
Gm21961 A T 15: 64,886,733 (GRCm39) D7E unknown Het
Gtf3a A G 5: 146,892,244 (GRCm39) K332E probably benign Het
Haao A G 17: 84,146,228 (GRCm39) probably null Het
Habp2 T A 19: 56,299,611 (GRCm39) C170S probably damaging Het
Heatr3 T G 8: 88,876,999 (GRCm39) probably null Het
Herc1 T G 9: 66,341,748 (GRCm39) C1846G possibly damaging Het
Hivep3 T C 4: 119,956,624 (GRCm39) S1647P probably benign Het
Hnrnpul1 C T 7: 25,426,300 (GRCm39) R517Q probably damaging Het
Hspg2 A G 4: 137,286,625 (GRCm39) E3648G probably damaging Het
Jaml T C 9: 45,012,449 (GRCm39) probably benign Het
Jund C T 8: 71,151,673 (GRCm39) probably benign Het
Klra14-ps T C 6: 130,134,595 (GRCm39) noncoding transcript Het
Krt88 G A 15: 101,350,809 (GRCm39) probably null Het
Lrp5 G A 19: 3,662,330 (GRCm39) R173C probably damaging Het
Lyzl4 T A 9: 121,412,101 (GRCm39) D105V probably damaging Het
Mst1 A G 9: 107,961,494 (GRCm39) I575V probably benign Het
Myd88 T C 9: 119,170,464 (GRCm39) probably benign Het
Myo1d A T 11: 80,557,404 (GRCm39) V512E probably damaging Het
Ndufv1 A G 19: 4,060,002 (GRCm39) Y33H probably damaging Het
Nwd1 T A 8: 73,394,439 (GRCm39) C608* probably null Het
Or10al2 T A 17: 37,983,684 (GRCm39) F257I probably damaging Het
Patj A T 4: 98,480,245 (GRCm39) K1317* probably null Het
Pld5 A G 1: 175,791,504 (GRCm39) S501P probably benign Het
Pnpo A G 11: 96,830,583 (GRCm39) V146A probably damaging Het
Ppdpf A G 2: 180,829,521 (GRCm39) Y16C probably benign Het
Ppp1r27 A G 11: 120,441,785 (GRCm39) V32A possibly damaging Het
Rbm28 T C 6: 29,154,788 (GRCm39) D294G probably benign Het
Sdk1 T A 5: 142,036,999 (GRCm39) D817E probably damaging Het
Shank3 A G 15: 89,387,587 (GRCm39) D252G possibly damaging Het
Slc29a1 A T 17: 45,899,899 (GRCm39) probably null Het
Slc35a5 G C 16: 44,978,521 (GRCm39) probably benign Het
Slc6a5 T C 7: 49,561,617 (GRCm39) S50P probably damaging Het
Slfn8 A T 11: 82,907,819 (GRCm39) Y241* probably null Het
Slu7 G T 11: 43,331,511 (GRCm39) probably null Het
Smad2 T A 18: 76,421,008 (GRCm39) D82E probably benign Het
Spx A C 6: 142,359,757 (GRCm39) E33A probably damaging Het
Tdp1 A G 12: 99,860,976 (GRCm39) Y205C probably damaging Het
Tekt1 A G 11: 72,236,574 (GRCm39) I296T possibly damaging Het
Tgm1 G A 14: 55,950,214 (GRCm39) probably benign Het
Tnks A G 8: 35,320,515 (GRCm39) S719P probably damaging Het
Trip6 A G 5: 137,311,941 (GRCm39) C47R probably benign Het
Trpv3 A G 11: 73,174,560 (GRCm39) D309G possibly damaging Het
Tti2 A G 8: 31,643,547 (GRCm39) K221E possibly damaging Het
Ugcg C T 4: 59,207,798 (GRCm39) P46S probably benign Het
Vmn1r57 A T 7: 5,223,630 (GRCm39) N52Y probably damaging Het
Vmn2r94 A G 17: 18,464,620 (GRCm39) F557L probably benign Het
Zbed5 T C 5: 129,931,118 (GRCm39) Y356H possibly damaging Het
Zfp1005 T A 2: 150,108,039 (GRCm39) probably benign Het
Zic4 C A 9: 91,266,394 (GRCm39) probably benign Het
Other mutations in Or8b37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00870:Or8b37 APN 9 37,959,036 (GRCm39) missense probably damaging 1.00
IGL02612:Or8b37 APN 9 37,958,662 (GRCm39) missense probably damaging 1.00
IGL02802:Or8b37 UTSW 9 37,959,345 (GRCm39) missense probably damaging 0.99
R0015:Or8b37 UTSW 9 37,958,963 (GRCm39) nonsense probably null
R0142:Or8b37 UTSW 9 37,959,406 (GRCm39) missense probably benign 0.37
R0559:Or8b37 UTSW 9 37,959,123 (GRCm39) missense probably benign 0.16
R0561:Or8b37 UTSW 9 37,959,123 (GRCm39) missense probably benign 0.16
R0715:Or8b37 UTSW 9 37,959,123 (GRCm39) missense probably benign 0.16
R0723:Or8b37 UTSW 9 37,959,123 (GRCm39) missense probably benign 0.16
R0729:Or8b37 UTSW 9 37,959,123 (GRCm39) missense probably benign 0.16
R1350:Or8b37 UTSW 9 37,959,111 (GRCm39) missense probably benign 0.02
R1869:Or8b37 UTSW 9 37,959,498 (GRCm39) splice site probably null
R4131:Or8b37 UTSW 9 37,959,170 (GRCm39) nonsense probably null
R4764:Or8b37 UTSW 9 37,959,436 (GRCm39) missense probably benign
R5857:Or8b37 UTSW 9 37,959,049 (GRCm39) missense probably benign 0.18
R5976:Or8b37 UTSW 9 37,958,997 (GRCm39) missense possibly damaging 0.80
R6329:Or8b37 UTSW 9 37,959,121 (GRCm39) missense probably benign 0.02
R7344:Or8b37 UTSW 9 37,959,253 (GRCm39) missense probably benign
R8289:Or8b37 UTSW 9 37,959,000 (GRCm39) missense probably benign 0.02
R8485:Or8b37 UTSW 9 37,959,253 (GRCm39) missense probably benign 0.00
R8973:Or8b37 UTSW 9 37,958,839 (GRCm39) missense possibly damaging 0.95
R9026:Or8b37 UTSW 9 37,958,885 (GRCm39) nonsense probably null
R9378:Or8b37 UTSW 9 37,958,775 (GRCm39) missense possibly damaging 0.67
R9395:Or8b37 UTSW 9 37,959,136 (GRCm39) missense probably damaging 0.99
R9655:Or8b37 UTSW 9 37,959,387 (GRCm39) missense probably benign 0.00
R9731:Or8b37 UTSW 9 37,958,892 (GRCm39) missense probably damaging 1.00
RF009:Or8b37 UTSW 9 37,959,043 (GRCm39) missense probably damaging 1.00
X0052:Or8b37 UTSW 9 37,958,995 (GRCm39) missense possibly damaging 0.53
Z1177:Or8b37 UTSW 9 37,959,111 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- CTTGGGAATCTATGTGGTCTCC -3'
(R):5'- GGTGAGTCTCAGCATGCAAAC -3'

Sequencing Primer
(F):5'- GTTCTGATTGTGTTGAATCCTCAC -3'
(R):5'- GTCTCAGCATGCAAACTATGTGG -3'
Posted On 2015-04-17