Incidental Mutation 'R3918:Mras'
ID 307505
Institutional Source Beutler Lab
Gene Symbol Mras
Ensembl Gene ENSMUSG00000032470
Gene Name muscle and microspikes RAS
Synonyms 2900078C09Rik
MMRRC Submission 040816-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.203) question?
Stock # R3918 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 99267473-99319434 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 99293473 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 56 (I56F)
Ref Sequence ENSEMBL: ENSMUSP00000121307 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035045] [ENSMUST00000119472] [ENSMUST00000122384] [ENSMUST00000123771]
AlphaFold O08989
Predicted Effect probably damaging
Transcript: ENSMUST00000035045
AA Change: I56F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000035045
Gene: ENSMUSG00000032470
AA Change: I56F

DomainStartEndE-ValueType
RAS 11 178 4.26e-114 SMART
low complexity region 182 191 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000119472
AA Change: I56F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000112407
Gene: ENSMUSG00000032470
AA Change: I56F

DomainStartEndE-ValueType
RAS 11 178 4.26e-114 SMART
low complexity region 182 191 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000122384
AA Change: I56F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000113275
Gene: ENSMUSG00000032470
AA Change: I56F

DomainStartEndE-ValueType
RAS 11 178 4.26e-114 SMART
low complexity region 182 191 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000123771
AA Change: I56F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000121307
Gene: ENSMUSG00000032470
AA Change: I56F

DomainStartEndE-ValueType
RAS 11 130 1.06e-68 SMART
Meta Mutation Damage Score 0.5846 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
PHENOTYPE: Mice homozygous for an insertional mutation that inactivates the gene exhibit a decreased mean percentage of peripheral blood B cells but no other evidence of morphological or neurological defects; mutant astrocytes display normal responsiveness to different trophic factors. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aars1 T C 8: 111,766,774 (GRCm39) I52T probably damaging Het
Adhfe1 G A 1: 9,646,441 (GRCm39) R447H probably damaging Het
Ak7 A G 12: 105,676,515 (GRCm39) K72E probably benign Het
Best2 T G 8: 85,736,353 (GRCm39) D270A probably damaging Het
Brinp3 C A 1: 146,627,599 (GRCm39) D277E probably damaging Het
Col18a1 T C 10: 76,889,192 (GRCm39) M1721V probably benign Het
Ctnnal1 T C 4: 56,865,000 (GRCm39) T39A possibly damaging Het
Dnah9 T A 11: 65,761,800 (GRCm39) M3897L possibly damaging Het
Dysf G A 6: 84,163,491 (GRCm39) probably null Het
Egf T C 3: 129,490,509 (GRCm39) I395V probably null Het
Fbln5 C T 12: 101,717,050 (GRCm39) G446D probably damaging Het
Gprc6a CAAA CA 10: 51,491,776 (GRCm39) probably null Het
Hmcn1 G C 1: 150,566,361 (GRCm39) T2214S probably benign Het
Lef1 A G 3: 130,905,290 (GRCm39) N57S probably damaging Het
Lpin1 A G 12: 16,621,190 (GRCm39) S266P probably benign Het
Marveld2 T C 13: 100,748,401 (GRCm39) Q226R probably benign Het
Mest G A 6: 30,742,749 (GRCm39) S132N probably benign Het
Myh13 G A 11: 67,220,064 (GRCm39) E138K probably benign Het
Nsun2 A G 13: 69,778,799 (GRCm39) T516A probably damaging Het
Ola1 A G 2: 72,972,683 (GRCm39) V200A probably benign Het
Or5ak24 A T 2: 85,261,074 (GRCm39) V33D possibly damaging Het
Patj C A 4: 98,344,455 (GRCm39) P20H probably damaging Het
Pcdhb12 T A 18: 37,570,101 (GRCm39) W416R probably benign Het
Pcdhga9 G A 18: 37,871,995 (GRCm39) R608H probably benign Het
Pola1 C A X: 92,505,078 (GRCm39) R1313L probably benign Het
Ppp1r36 G A 12: 76,464,431 (GRCm39) V10I probably benign Het
Rnf150 C T 8: 83,591,090 (GRCm39) T151I probably benign Het
Tank G T 2: 61,474,130 (GRCm39) probably null Het
Tmprss4 C T 9: 45,091,964 (GRCm39) V174M probably benign Het
Trappc13 T C 13: 104,297,590 (GRCm39) T105A probably damaging Het
Tut7 A G 13: 59,929,838 (GRCm39) S1066P probably damaging Het
Txndc9 G A 1: 38,033,131 (GRCm39) Q84* probably null Het
Ubr3 A T 2: 69,846,474 (GRCm39) probably null Het
Wfs1 C A 5: 37,125,968 (GRCm39) V308L probably benign Het
Zfp51 A G 17: 21,683,702 (GRCm39) K106E probably benign Het
Other mutations in Mras
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01759:Mras APN 9 99,293,548 (GRCm39) missense probably damaging 1.00
R3919:Mras UTSW 9 99,293,473 (GRCm39) missense probably damaging 1.00
R3981:Mras UTSW 9 99,293,469 (GRCm39) missense probably damaging 1.00
R4950:Mras UTSW 9 99,276,537 (GRCm39) missense probably damaging 1.00
R5375:Mras UTSW 9 99,276,669 (GRCm39) missense probably damaging 1.00
R5501:Mras UTSW 9 99,293,599 (GRCm39) missense probably damaging 1.00
R5624:Mras UTSW 9 99,293,538 (GRCm39) missense probably damaging 0.99
R6349:Mras UTSW 9 99,276,669 (GRCm39) missense probably damaging 1.00
R6350:Mras UTSW 9 99,293,560 (GRCm39) missense probably damaging 1.00
R7453:Mras UTSW 9 99,271,793 (GRCm39) missense probably benign 0.01
R8351:Mras UTSW 9 99,293,548 (GRCm39) missense probably damaging 1.00
R8451:Mras UTSW 9 99,293,548 (GRCm39) missense probably damaging 1.00
R9622:Mras UTSW 9 99,275,054 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CCACTTTCGTTGCCACTAAG -3'
(R):5'- TGACTACCAGAAACATGGCG -3'

Sequencing Primer
(F):5'- CGTTGCCACTAAGATCATTAAGCAG -3'
(R):5'- GACCAGCGCTGTTCCAAGTG -3'
Posted On 2015-04-17