Incidental Mutation 'R3943:Atf3'
ID 307524
Institutional Source Beutler Lab
Gene Symbol Atf3
Ensembl Gene ENSMUSG00000026628
Gene Name activating transcription factor 3
Synonyms LRG-21
MMRRC Submission 040924-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3943 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 190902493-190915530 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 190903713 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 171 (I171T)
Ref Sequence ENSEMBL: ENSMUSP00000141492 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027941] [ENSMUST00000195117]
AlphaFold Q60765
Predicted Effect possibly damaging
Transcript: ENSMUST00000027941
AA Change: I171T

PolyPhen 2 Score 0.807 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000027941
Gene: ENSMUSG00000026628
AA Change: I171T

DomainStartEndE-ValueType
BRLZ 84 148 6.45e-18 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131854
Predicted Effect possibly damaging
Transcript: ENSMUST00000195117
AA Change: I171T

PolyPhen 2 Score 0.807 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000141492
Gene: ENSMUSG00000026628
AA Change: I171T

DomainStartEndE-ValueType
BRLZ 84 148 6.45e-18 SMART
Meta Mutation Damage Score 0.1010 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency 98% (49/50)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011]
PHENOTYPE: Homozygous null mice display enhanced allergen-induced airway hyperresponsiveness, pulmonary eosinophilia, and chemokine and Th2 cytokine responses in lung tissue and lung-derived CD4+ lymphocytes. Primary pancreatic islets are partially protected from cytokine- or nitric oxide-induced apoptosis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adnp A G 2: 168,026,980 (GRCm39) I105T possibly damaging Het
Atp6v0a1 A G 11: 100,946,343 (GRCm39) I773V probably benign Het
Bltp2 T A 11: 78,160,350 (GRCm39) L603* probably null Het
Cad T A 5: 31,229,729 (GRCm39) probably null Het
Camkv T A 9: 107,825,182 (GRCm39) D366E possibly damaging Het
Dnah8 T A 17: 30,913,039 (GRCm39) probably benign Het
Dock7 A G 4: 98,880,668 (GRCm39) S932P probably damaging Het
Fam227a C T 15: 79,505,060 (GRCm39) probably benign Het
Fbp2 A G 13: 62,989,607 (GRCm39) F233S possibly damaging Het
Gnptab G T 10: 88,269,756 (GRCm39) V820L probably benign Het
Gpat4 G A 8: 23,670,171 (GRCm39) P286L probably damaging Het
Gpr158 C A 2: 21,373,370 (GRCm39) R102S possibly damaging Het
Gramd1b A T 9: 40,442,340 (GRCm39) M1K probably null Het
H2-T23 A G 17: 36,341,535 (GRCm39) V312A probably benign Het
Hltf A T 3: 20,146,908 (GRCm39) I494F probably damaging Het
Il16 G A 7: 83,301,223 (GRCm39) L300F probably damaging Het
Insyn1 AGAGGAGGAGGAGGAGG AGAGGAGGAGGAGG 9: 58,406,715 (GRCm39) probably benign Het
Kcnq1 T C 7: 142,979,825 (GRCm39) L657P probably damaging Het
Krt4 G A 15: 101,829,685 (GRCm39) T281M probably benign Het
Mia3 A G 1: 183,140,127 (GRCm39) F196S possibly damaging Het
Naip6 T C 13: 100,431,247 (GRCm39) T1197A probably benign Het
Nrxn2 T A 19: 6,523,365 (GRCm39) N204K probably damaging Het
Or7g27 T A 9: 19,250,371 (GRCm39) M205K probably benign Het
Rassf6 G T 5: 90,752,185 (GRCm39) Q258K possibly damaging Het
Rhpn1 T C 15: 75,583,655 (GRCm39) L380P probably damaging Het
Ribc2 A G 15: 85,019,451 (GRCm39) M78V probably benign Het
Shroom3 G T 5: 93,090,945 (GRCm39) V1151F probably damaging Het
Skint5 T A 4: 113,799,950 (GRCm39) H73L probably damaging Het
Smg6 G A 11: 74,820,367 (GRCm39) G213R probably damaging Het
Sspn T A 6: 145,880,083 (GRCm39) W62R probably damaging Het
Stard9 A G 2: 120,528,710 (GRCm39) S1656G probably benign Het
Svep1 T A 4: 58,084,807 (GRCm39) probably null Het
Tab1 T C 15: 80,037,941 (GRCm39) L258P probably damaging Het
Tmem59l A G 8: 70,939,951 (GRCm39) L6S unknown Het
Tnrc6c C T 11: 117,614,355 (GRCm39) R838W probably damaging Het
Trf T A 9: 103,100,151 (GRCm39) I271F probably benign Het
Trpm7 A T 2: 126,673,138 (GRCm39) N538K possibly damaging Het
Usp28 T A 9: 48,911,666 (GRCm39) L25I probably benign Het
Vmn2r14 A T 5: 109,363,930 (GRCm39) I662N probably damaging Het
Vmn2r42 A T 7: 8,197,779 (GRCm39) F280Y possibly damaging Het
Vps8 A T 16: 21,288,873 (GRCm39) N411Y probably damaging Het
Vwa2 T G 19: 56,897,747 (GRCm39) L684R probably damaging Het
Zfp712 T C 13: 67,189,396 (GRCm39) Q377R probably benign Het
Zfp947 C A 17: 22,364,801 (GRCm39) G291V probably damaging Het
Zpld2 T C 4: 133,927,656 (GRCm39) T366A probably benign Het
Other mutations in Atf3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01511:Atf3 APN 1 190,903,693 (GRCm39) missense probably benign 0.03
IGL02954:Atf3 APN 1 190,903,852 (GRCm39) missense probably damaging 1.00
IGL02971:Atf3 APN 1 190,909,640 (GRCm39) missense probably benign
R5001:Atf3 UTSW 1 190,909,472 (GRCm39) missense probably benign 0.01
R8815:Atf3 UTSW 1 190,909,564 (GRCm39) missense probably benign 0.10
R9377:Atf3 UTSW 1 190,909,510 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TTGGTGAGACAAAGGATGCTCC -3'
(R):5'- CCTCAGGAGTCAGAGAAACTGG -3'

Sequencing Primer
(F):5'- GGTCAATGCAGTAGGTCACCAC -3'
(R):5'- CTGGAGAGTGTGAATGCTGAGC -3'
Posted On 2015-04-17