Incidental Mutation 'R3943:Gpr158'
ID 307525
Institutional Source Beutler Lab
Gene Symbol Gpr158
Ensembl Gene ENSMUSG00000045967
Gene Name G protein-coupled receptor 158
Synonyms 5330427M13Rik
MMRRC Submission 040924-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3943 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 21372378-21835355 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 21373370 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Serine at position 102 (R102S)
Ref Sequence ENSEMBL: ENSMUSP00000049708 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055946]
AlphaFold Q8C419
Predicted Effect possibly damaging
Transcript: ENSMUST00000055946
AA Change: R102S

PolyPhen 2 Score 0.650 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000049708
Gene: ENSMUSG00000045967
AA Change: R102S

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
low complexity region 110 125 N/A INTRINSIC
SCOP:d1edmb_ 313 359 5e-4 SMART
Blast:EGF 318 365 2e-27 BLAST
Pfam:7tm_3 426 669 1.2e-35 PFAM
low complexity region 840 863 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133391
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155760
Meta Mutation Damage Score 0.1232 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency 98% (49/50)
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adnp A G 2: 168,026,980 (GRCm39) I105T possibly damaging Het
Atf3 A G 1: 190,903,713 (GRCm39) I171T possibly damaging Het
Atp6v0a1 A G 11: 100,946,343 (GRCm39) I773V probably benign Het
Bltp2 T A 11: 78,160,350 (GRCm39) L603* probably null Het
Cad T A 5: 31,229,729 (GRCm39) probably null Het
Camkv T A 9: 107,825,182 (GRCm39) D366E possibly damaging Het
Dnah8 T A 17: 30,913,039 (GRCm39) probably benign Het
Dock7 A G 4: 98,880,668 (GRCm39) S932P probably damaging Het
Fam227a C T 15: 79,505,060 (GRCm39) probably benign Het
Fbp2 A G 13: 62,989,607 (GRCm39) F233S possibly damaging Het
Gnptab G T 10: 88,269,756 (GRCm39) V820L probably benign Het
Gpat4 G A 8: 23,670,171 (GRCm39) P286L probably damaging Het
Gramd1b A T 9: 40,442,340 (GRCm39) M1K probably null Het
H2-T23 A G 17: 36,341,535 (GRCm39) V312A probably benign Het
Hltf A T 3: 20,146,908 (GRCm39) I494F probably damaging Het
Il16 G A 7: 83,301,223 (GRCm39) L300F probably damaging Het
Insyn1 AGAGGAGGAGGAGGAGG AGAGGAGGAGGAGG 9: 58,406,715 (GRCm39) probably benign Het
Kcnq1 T C 7: 142,979,825 (GRCm39) L657P probably damaging Het
Krt4 G A 15: 101,829,685 (GRCm39) T281M probably benign Het
Mia3 A G 1: 183,140,127 (GRCm39) F196S possibly damaging Het
Naip6 T C 13: 100,431,247 (GRCm39) T1197A probably benign Het
Nrxn2 T A 19: 6,523,365 (GRCm39) N204K probably damaging Het
Or7g27 T A 9: 19,250,371 (GRCm39) M205K probably benign Het
Rassf6 G T 5: 90,752,185 (GRCm39) Q258K possibly damaging Het
Rhpn1 T C 15: 75,583,655 (GRCm39) L380P probably damaging Het
Ribc2 A G 15: 85,019,451 (GRCm39) M78V probably benign Het
Shroom3 G T 5: 93,090,945 (GRCm39) V1151F probably damaging Het
Skint5 T A 4: 113,799,950 (GRCm39) H73L probably damaging Het
Smg6 G A 11: 74,820,367 (GRCm39) G213R probably damaging Het
Sspn T A 6: 145,880,083 (GRCm39) W62R probably damaging Het
Stard9 A G 2: 120,528,710 (GRCm39) S1656G probably benign Het
Svep1 T A 4: 58,084,807 (GRCm39) probably null Het
Tab1 T C 15: 80,037,941 (GRCm39) L258P probably damaging Het
Tmem59l A G 8: 70,939,951 (GRCm39) L6S unknown Het
Tnrc6c C T 11: 117,614,355 (GRCm39) R838W probably damaging Het
Trf T A 9: 103,100,151 (GRCm39) I271F probably benign Het
Trpm7 A T 2: 126,673,138 (GRCm39) N538K possibly damaging Het
Usp28 T A 9: 48,911,666 (GRCm39) L25I probably benign Het
Vmn2r14 A T 5: 109,363,930 (GRCm39) I662N probably damaging Het
Vmn2r42 A T 7: 8,197,779 (GRCm39) F280Y possibly damaging Het
Vps8 A T 16: 21,288,873 (GRCm39) N411Y probably damaging Het
Vwa2 T G 19: 56,897,747 (GRCm39) L684R probably damaging Het
Zfp712 T C 13: 67,189,396 (GRCm39) Q377R probably benign Het
Zfp947 C A 17: 22,364,801 (GRCm39) G291V probably damaging Het
Zpld2 T C 4: 133,927,656 (GRCm39) T366A probably benign Het
Other mutations in Gpr158
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00340:Gpr158 APN 2 21,373,494 (GRCm39) missense probably damaging 1.00
IGL00469:Gpr158 APN 2 21,751,606 (GRCm39) splice site probably benign
IGL00706:Gpr158 APN 2 21,751,584 (GRCm39) missense probably damaging 1.00
IGL00780:Gpr158 APN 2 21,831,629 (GRCm39) nonsense probably null
IGL00885:Gpr158 APN 2 21,653,832 (GRCm39) missense probably damaging 1.00
IGL01339:Gpr158 APN 2 21,373,842 (GRCm39) missense possibly damaging 0.73
IGL01368:Gpr158 APN 2 21,831,909 (GRCm39) missense probably damaging 1.00
IGL02141:Gpr158 APN 2 21,788,101 (GRCm39) missense probably damaging 0.99
IGL02455:Gpr158 APN 2 21,373,511 (GRCm39) missense probably benign 0.00
IGL02554:Gpr158 APN 2 21,831,407 (GRCm39) missense probably benign
IGL02681:Gpr158 APN 2 21,820,441 (GRCm39) missense probably damaging 1.00
IGL02752:Gpr158 APN 2 21,831,638 (GRCm39) missense possibly damaging 0.95
IGL02756:Gpr158 APN 2 21,831,890 (GRCm39) missense possibly damaging 0.47
IGL03181:Gpr158 APN 2 21,787,972 (GRCm39) missense probably benign 0.02
IGL03258:Gpr158 APN 2 21,830,085 (GRCm39) missense probably damaging 1.00
IGL03386:Gpr158 APN 2 21,831,057 (GRCm39) missense probably damaging 1.00
PIT4810001:Gpr158 UTSW 2 21,831,682 (GRCm39) missense probably benign 0.01
R0071:Gpr158 UTSW 2 21,815,479 (GRCm39) missense probably benign 0.08
R0081:Gpr158 UTSW 2 21,831,528 (GRCm39) missense probably damaging 1.00
R0528:Gpr158 UTSW 2 21,830,019 (GRCm39) missense probably damaging 1.00
R0560:Gpr158 UTSW 2 21,830,085 (GRCm39) missense probably damaging 1.00
R0603:Gpr158 UTSW 2 21,820,480 (GRCm39) missense possibly damaging 0.67
R1560:Gpr158 UTSW 2 21,831,125 (GRCm39) missense probably damaging 1.00
R1561:Gpr158 UTSW 2 21,820,505 (GRCm39) splice site probably null
R1609:Gpr158 UTSW 2 21,788,104 (GRCm39) missense possibly damaging 0.61
R1741:Gpr158 UTSW 2 21,832,359 (GRCm39) missense probably benign 0.00
R1827:Gpr158 UTSW 2 21,832,129 (GRCm39) missense probably benign
R1854:Gpr158 UTSW 2 21,373,935 (GRCm39) missense probably damaging 1.00
R1871:Gpr158 UTSW 2 21,820,426 (GRCm39) missense probably damaging 1.00
R2151:Gpr158 UTSW 2 21,832,325 (GRCm39) missense possibly damaging 0.82
R2273:Gpr158 UTSW 2 21,831,674 (GRCm39) missense probably benign
R2275:Gpr158 UTSW 2 21,831,674 (GRCm39) missense probably benign
R3004:Gpr158 UTSW 2 21,831,810 (GRCm39) missense probably damaging 0.99
R3151:Gpr158 UTSW 2 21,581,771 (GRCm39) missense possibly damaging 0.68
R4238:Gpr158 UTSW 2 21,373,362 (GRCm39) missense probably damaging 1.00
R4379:Gpr158 UTSW 2 21,830,025 (GRCm39) missense probably damaging 1.00
R4381:Gpr158 UTSW 2 21,832,403 (GRCm39) missense probably damaging 1.00
R4464:Gpr158 UTSW 2 21,831,810 (GRCm39) missense probably damaging 0.99
R4467:Gpr158 UTSW 2 21,831,810 (GRCm39) missense probably damaging 0.99
R4496:Gpr158 UTSW 2 21,831,810 (GRCm39) missense probably damaging 0.99
R4506:Gpr158 UTSW 2 21,831,810 (GRCm39) missense probably damaging 0.99
R4530:Gpr158 UTSW 2 21,373,811 (GRCm39) missense probably benign 0.03
R4646:Gpr158 UTSW 2 21,831,864 (GRCm39) missense probably benign
R4798:Gpr158 UTSW 2 21,787,993 (GRCm39) missense probably damaging 1.00
R4882:Gpr158 UTSW 2 21,830,059 (GRCm39) missense probably damaging 0.98
R4943:Gpr158 UTSW 2 21,831,968 (GRCm39) missense probably damaging 1.00
R5334:Gpr158 UTSW 2 21,832,316 (GRCm39) missense probably benign 0.01
R5560:Gpr158 UTSW 2 21,831,101 (GRCm39) missense possibly damaging 0.67
R5600:Gpr158 UTSW 2 21,832,046 (GRCm39) missense probably benign
R5637:Gpr158 UTSW 2 21,788,083 (GRCm39) missense probably benign 0.00
R5701:Gpr158 UTSW 2 21,751,520 (GRCm39) missense probably damaging 1.00
R5744:Gpr158 UTSW 2 21,373,331 (GRCm39) missense probably damaging 1.00
R5911:Gpr158 UTSW 2 21,373,932 (GRCm39) missense possibly damaging 0.95
R5991:Gpr158 UTSW 2 21,373,319 (GRCm39) missense probably damaging 0.99
R6200:Gpr158 UTSW 2 21,404,227 (GRCm39) missense probably damaging 0.97
R6306:Gpr158 UTSW 2 21,820,422 (GRCm39) missense possibly damaging 0.84
R6324:Gpr158 UTSW 2 21,815,365 (GRCm39) missense probably damaging 1.00
R6384:Gpr158 UTSW 2 21,831,099 (GRCm39) missense probably damaging 1.00
R6698:Gpr158 UTSW 2 21,831,921 (GRCm39) missense probably damaging 1.00
R6997:Gpr158 UTSW 2 21,653,802 (GRCm39) missense possibly damaging 0.46
R7086:Gpr158 UTSW 2 21,831,386 (GRCm39) missense probably benign 0.01
R7175:Gpr158 UTSW 2 21,373,113 (GRCm39) missense probably benign 0.13
R7197:Gpr158 UTSW 2 21,815,412 (GRCm39) missense probably damaging 0.99
R7293:Gpr158 UTSW 2 21,581,750 (GRCm39) missense possibly damaging 0.47
R7427:Gpr158 UTSW 2 21,832,129 (GRCm39) missense probably benign
R7515:Gpr158 UTSW 2 21,373,092 (GRCm39) missense probably damaging 1.00
R7730:Gpr158 UTSW 2 21,831,158 (GRCm39) missense probably damaging 1.00
R8122:Gpr158 UTSW 2 21,831,674 (GRCm39) missense probably benign
R8311:Gpr158 UTSW 2 21,373,701 (GRCm39) missense probably benign 0.00
R8754:Gpr158 UTSW 2 21,581,693 (GRCm39) missense probably benign 0.00
R8782:Gpr158 UTSW 2 21,404,149 (GRCm39) missense probably damaging 1.00
R8792:Gpr158 UTSW 2 21,558,137 (GRCm39) missense probably damaging 1.00
R8842:Gpr158 UTSW 2 21,581,751 (GRCm39) missense possibly damaging 0.88
R9009:Gpr158 UTSW 2 21,581,760 (GRCm39) missense probably damaging 1.00
R9102:Gpr158 UTSW 2 21,830,078 (GRCm39) missense probably damaging 1.00
R9150:Gpr158 UTSW 2 21,831,251 (GRCm39) missense probably benign 0.17
R9254:Gpr158 UTSW 2 21,373,042 (GRCm39) start gained probably benign
R9317:Gpr158 UTSW 2 21,832,037 (GRCm39) missense probably benign
R9379:Gpr158 UTSW 2 21,373,042 (GRCm39) start gained probably benign
R9428:Gpr158 UTSW 2 21,787,972 (GRCm39) missense probably benign
R9497:Gpr158 UTSW 2 21,831,825 (GRCm39) missense probably benign 0.00
R9667:Gpr158 UTSW 2 21,830,054 (GRCm39) missense probably damaging 0.99
R9681:Gpr158 UTSW 2 21,831,315 (GRCm39) missense probably damaging 0.99
X0062:Gpr158 UTSW 2 21,831,180 (GRCm39) missense probably damaging 1.00
Z1176:Gpr158 UTSW 2 21,815,501 (GRCm39) critical splice donor site probably null
Z1177:Gpr158 UTSW 2 21,832,083 (GRCm39) missense possibly damaging 0.46
Predicted Primers PCR Primer
(F):5'- ATGCTAGACAGATGGGAGCC -3'
(R):5'- TGGTACCACTGCAGGTCATC -3'

Sequencing Primer
(F):5'- CTGCTCGCTCATCTGGGATTG -3'
(R):5'- AGGTCATCCTGCACGGTCTG -3'
Posted On 2015-04-17