Incidental Mutation 'R3945:Rpl37'
ID 307672
Institutional Source Beutler Lab
Gene Symbol Rpl37
Ensembl Gene ENSMUSG00000041841
Gene Name ribosomal protein L37
Synonyms 3110005M08Rik
MMRRC Submission 040926-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.961) question?
Stock # R3945 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 5146127-5148622 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 5147176 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Histidine at position 72 (R72H)
Ref Sequence ENSEMBL: ENSMUSP00000046506 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045356] [ENSMUST00000090488]
AlphaFold Q9D823
Predicted Effect probably benign
Transcript: ENSMUST00000045356
AA Change: R72H

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000046506
Gene: ENSMUSG00000041841
AA Change: R72H

DomainStartEndE-ValueType
Pfam:Ribosomal_L37e 2 54 3.9e-30 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000090488
SMART Domains Protein: ENSMUSP00000087974
Gene: ENSMUSG00000068706

DomainStartEndE-ValueType
Pfam:Mt_ATP-synt_D 3 159 8.7e-70 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000104549
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226758
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227111
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227463
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227635
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227674
Meta Mutation Damage Score 0.1925 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency 100% (54/54)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L37E family of ribosomal proteins. It is located in the cytoplasm. The protein contains a C2C2-type zinc finger-like motif. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930407I10Rik T C 15: 81,949,601 (GRCm39) L1166P probably damaging Het
Actn4 T C 7: 28,611,661 (GRCm39) probably null Het
Adamts17 A T 7: 66,770,687 (GRCm39) E905V probably benign Het
Adck5 A G 15: 76,479,400 (GRCm39) N485S probably damaging Het
Agr3 C A 12: 35,997,512 (GRCm39) probably benign Het
Ankrd12 G A 17: 66,283,098 (GRCm39) T1921I probably damaging Het
Ascl2 T C 7: 142,521,708 (GRCm39) S247G probably benign Het
Atp7b T C 8: 22,510,880 (GRCm39) E422G probably benign Het
Bltp2 T C 11: 78,180,790 (GRCm39) I2229T probably damaging Het
C630050I24Rik C T 8: 107,845,894 (GRCm39) R15* probably null Het
Cabin1 T G 10: 75,581,093 (GRCm39) Q411P probably damaging Het
Chrne T C 11: 70,507,869 (GRCm39) I277V possibly damaging Het
Coch A G 12: 51,648,595 (GRCm39) probably null Het
Corin A G 5: 72,515,767 (GRCm39) V429A probably damaging Het
Cpa3 A T 3: 20,279,281 (GRCm39) N219K probably damaging Het
Creb3l1 T C 2: 91,821,556 (GRCm39) E273G probably damaging Het
Csmd1 A C 8: 15,960,619 (GRCm39) probably null Het
Ddx59 A G 1: 136,362,356 (GRCm39) D527G probably damaging Het
Defa25 G A 8: 21,574,506 (GRCm39) V17I probably null Het
Efs A G 14: 55,158,108 (GRCm39) probably benign Het
Ern2 A G 7: 121,775,753 (GRCm39) M447T probably benign Het
Fgfr2 C T 7: 129,779,485 (GRCm39) E596K possibly damaging Het
Filip1 T C 9: 79,725,649 (GRCm39) K990R probably benign Het
Ipo8 T A 6: 148,719,615 (GRCm39) Q110L probably damaging Het
Kank4 T A 4: 98,659,517 (GRCm39) I854F probably damaging Het
Mst1 G A 9: 107,962,052 (GRCm39) C681Y probably damaging Het
Nr2c2 C T 6: 92,140,119 (GRCm39) R464W probably damaging Het
Or1s2 A G 19: 13,758,786 (GRCm39) E270G probably benign Het
Or4f4b C T 2: 111,314,032 (GRCm39) Q86* probably null Het
Pde11a T C 2: 75,906,275 (GRCm39) probably benign Het
Ptprq A G 10: 107,522,253 (GRCm39) probably benign Het
Rcbtb1 G A 14: 59,462,225 (GRCm39) probably null Het
Samd9l A T 6: 3,377,029 (GRCm39) S77R possibly damaging Het
Sin3b A G 8: 73,460,067 (GRCm39) D218G possibly damaging Het
Slc22a23 A G 13: 34,367,109 (GRCm39) I633T probably damaging Het
Spen T C 4: 141,204,664 (GRCm39) D1321G unknown Het
Ssh2 T C 11: 77,345,494 (GRCm39) S1160P possibly damaging Het
Synrg T A 11: 83,914,232 (GRCm39) D952E probably damaging Het
Tigd3 A G 19: 5,942,461 (GRCm39) F223S probably damaging Het
Trim66 G A 7: 109,071,475 (GRCm39) T608I possibly damaging Het
Trmt13 A G 3: 116,375,167 (GRCm39) F447S probably damaging Het
Trpc2 T C 7: 101,737,486 (GRCm39) I800T possibly damaging Het
Ugt3a1 A T 15: 9,370,184 (GRCm39) I443F possibly damaging Het
Vamp2 C A 11: 68,980,000 (GRCm39) P24Q unknown Het
Vmn1r113 A G 7: 20,521,637 (GRCm39) Y143C probably benign Het
Vmn1r14 T A 6: 57,211,254 (GRCm39) N277K probably benign Het
Vmn1r181 T A 7: 23,683,577 (GRCm39) V14E probably damaging Het
Wdfy4 A T 14: 32,688,352 (GRCm39) I3086N probably damaging Het
Zfp988 A C 4: 147,417,242 (GRCm39) K559Q probably benign Het
Other mutations in Rpl37
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1470:Rpl37 UTSW 15 5,148,096 (GRCm39) missense probably benign 0.00
R1470:Rpl37 UTSW 15 5,148,096 (GRCm39) missense probably benign 0.00
R1887:Rpl37 UTSW 15 5,148,072 (GRCm39) missense possibly damaging 0.62
R3754:Rpl37 UTSW 15 5,146,770 (GRCm39) missense possibly damaging 0.52
R4959:Rpl37 UTSW 15 5,147,128 (GRCm39) missense possibly damaging 0.61
R4973:Rpl37 UTSW 15 5,147,128 (GRCm39) missense possibly damaging 0.61
R6366:Rpl37 UTSW 15 5,147,990 (GRCm39) splice site probably null
R7037:Rpl37 UTSW 15 5,147,185 (GRCm39) missense probably null 0.00
R9154:Rpl37 UTSW 15 5,147,109 (GRCm39) missense probably benign 0.26
Z1176:Rpl37 UTSW 15 5,148,074 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- ACGCAACAACTTTGGAGGTTG -3'
(R):5'- GAACAGCTTAGCAGACTTGAGC -3'

Sequencing Primer
(F):5'- CAACAACTTTGGAGGTTGGTTTG -3'
(R):5'- CTTGAGCAAAGTCTGGAGGC -3'
Posted On 2015-04-17