Incidental Mutation 'R3946:Vmn2r25'
| ID |
307708 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r25
|
| Ensembl Gene |
ENSMUSG00000094672 |
| Gene Name |
vomeronasal 2, receptor 25 |
| Synonyms |
EG545874 |
| MMRRC Submission |
040827-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.140)
|
| Stock # |
R3946 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
123799773-123830149 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 123817057 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Histidine
at position 175
(Y175H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124342
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000162046]
|
| AlphaFold |
W4VSP2 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000162046
AA Change: Y175H
PolyPhen 2
Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000124342
Gene: ENSMUSG00000094672
AA Change: Y175H
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
473 |
6e-31 |
PFAM |
|
Pfam:NCD3G
|
519 |
572 |
5.8e-25 |
PFAM |
|
Pfam:7tm_3
|
603 |
840 |
4.8e-55 |
PFAM |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.0%
- 20x: 94.1%
|
| Validation Efficiency |
98% (60/61) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 61 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abi2 |
A |
G |
1: 60,492,913 (GRCm39) |
Q328R |
probably damaging |
Het |
| Agr3 |
C |
A |
12: 35,997,512 (GRCm39) |
|
probably benign |
Het |
| Brca2 |
T |
A |
5: 150,460,169 (GRCm39) |
S481R |
probably damaging |
Het |
| Cabin1 |
T |
G |
10: 75,581,093 (GRCm39) |
Q411P |
probably damaging |
Het |
| Calr3 |
A |
G |
8: 73,197,464 (GRCm39) |
Y22H |
probably damaging |
Het |
| Caprin1 |
T |
A |
2: 103,627,111 (GRCm39) |
I59F |
probably damaging |
Het |
| Cdk5rap1 |
T |
C |
2: 154,190,636 (GRCm39) |
T442A |
probably damaging |
Het |
| Chn2 |
T |
C |
6: 54,246,411 (GRCm39) |
|
probably benign |
Het |
| Cic |
C |
A |
7: 24,971,771 (GRCm39) |
R501S |
possibly damaging |
Het |
| Coch |
A |
G |
12: 51,648,595 (GRCm39) |
|
probably null |
Het |
| Defa25 |
G |
A |
8: 21,574,506 (GRCm39) |
V17I |
probably null |
Het |
| Dglucy |
T |
C |
12: 100,804,959 (GRCm39) |
|
probably null |
Het |
| Dtx1 |
T |
G |
5: 120,819,351 (GRCm39) |
T616P |
possibly damaging |
Het |
| Eef1g |
T |
C |
19: 8,947,341 (GRCm39) |
L171P |
probably benign |
Het |
| Fam135a |
A |
G |
1: 24,069,475 (GRCm39) |
S465P |
probably damaging |
Het |
| Gm14412 |
A |
T |
2: 177,006,478 (GRCm39) |
C472* |
probably null |
Het |
| Gm7104 |
T |
C |
12: 88,252,812 (GRCm39) |
|
noncoding transcript |
Het |
| Got2 |
A |
G |
8: 96,614,858 (GRCm39) |
S26P |
probably benign |
Het |
| H2-M11 |
A |
G |
17: 36,860,123 (GRCm39) |
I329M |
probably damaging |
Het |
| Hmcn2 |
T |
A |
2: 31,272,406 (GRCm39) |
D1295E |
possibly damaging |
Het |
| Hoxd12 |
G |
T |
2: 74,505,771 (GRCm39) |
R114L |
probably damaging |
Het |
| Ilkap |
A |
C |
1: 91,314,972 (GRCm39) |
D124E |
probably damaging |
Het |
| Maco1 |
A |
G |
4: 134,531,792 (GRCm39) |
Y626H |
probably damaging |
Het |
| Med6 |
T |
C |
12: 81,628,625 (GRCm39) |
Y88C |
probably damaging |
Het |
| Mep1a |
A |
T |
17: 43,785,932 (GRCm39) |
L719* |
probably null |
Het |
| Mmp23 |
T |
C |
4: 155,736,480 (GRCm39) |
Y187C |
probably damaging |
Het |
| Myo1g |
A |
G |
11: 6,470,760 (GRCm39) |
M32T |
possibly damaging |
Het |
| Ncstn |
T |
C |
1: 171,895,061 (GRCm39) |
E614G |
probably benign |
Het |
| Nr2c2 |
C |
T |
6: 92,140,119 (GRCm39) |
R464W |
probably damaging |
Het |
| Or4f15 |
G |
A |
2: 111,813,642 (GRCm39) |
T259M |
possibly damaging |
Het |
| Otub2 |
T |
A |
12: 103,359,085 (GRCm39) |
L58* |
probably null |
Het |
| Pcdhga12 |
G |
A |
18: 37,900,682 (GRCm39) |
V505I |
probably benign |
Het |
| Pcdhga9 |
T |
A |
18: 37,870,897 (GRCm39) |
V242D |
probably damaging |
Het |
| Pex1 |
C |
T |
5: 3,676,084 (GRCm39) |
L891F |
probably damaging |
Het |
| Pgm2 |
C |
T |
5: 64,269,404 (GRCm39) |
T497I |
probably benign |
Het |
| Pikfyve |
T |
C |
1: 65,235,840 (GRCm39) |
F171L |
probably damaging |
Het |
| Pilrb1 |
T |
G |
5: 137,855,654 (GRCm39) |
K79T |
probably benign |
Het |
| Pin1 |
C |
T |
9: 20,566,660 (GRCm39) |
R21W |
probably damaging |
Het |
| Prxl2c |
T |
C |
13: 64,456,912 (GRCm39) |
I104V |
probably damaging |
Het |
| Ptprq |
A |
G |
10: 107,522,253 (GRCm39) |
|
probably benign |
Het |
| Rad17 |
G |
A |
13: 100,759,371 (GRCm39) |
A552V |
possibly damaging |
Het |
| Rbbp8 |
A |
G |
18: 11,851,925 (GRCm39) |
T249A |
probably benign |
Het |
| Rtkn |
A |
T |
6: 83,112,957 (GRCm39) |
I10F |
probably benign |
Het |
| Scube2 |
T |
A |
7: 109,456,797 (GRCm39) |
I103F |
possibly damaging |
Het |
| Sec23b |
A |
G |
2: 144,423,893 (GRCm39) |
H514R |
probably benign |
Het |
| Serbp1 |
T |
A |
6: 67,249,204 (GRCm39) |
D223E |
probably benign |
Het |
| Slc14a1 |
C |
A |
18: 78,154,607 (GRCm39) |
V260L |
probably benign |
Het |
| Slc22a23 |
A |
G |
13: 34,367,109 (GRCm39) |
I633T |
probably damaging |
Het |
| Stk19 |
A |
T |
17: 35,043,723 (GRCm39) |
|
probably benign |
Het |
| Svs5 |
T |
C |
2: 164,079,047 (GRCm39) |
M287V |
probably benign |
Het |
| Syne3 |
T |
A |
12: 104,924,325 (GRCm39) |
Q358L |
probably damaging |
Het |
| Synj1 |
A |
G |
16: 90,806,984 (GRCm39) |
F58L |
possibly damaging |
Het |
| Tg |
T |
C |
15: 66,545,872 (GRCm39) |
V198A |
probably damaging |
Het |
| Tle4 |
A |
T |
19: 14,574,752 (GRCm39) |
Y9N |
probably damaging |
Het |
| Tmx3 |
G |
A |
18: 90,542,459 (GRCm39) |
A186T |
possibly damaging |
Het |
| Traf3 |
G |
A |
12: 111,221,679 (GRCm39) |
S280N |
possibly damaging |
Het |
| Trmt13 |
A |
G |
3: 116,375,167 (GRCm39) |
F447S |
probably damaging |
Het |
| Trp53bp1 |
T |
A |
2: 121,059,107 (GRCm39) |
H918L |
probably damaging |
Het |
| Ush2a |
T |
G |
1: 188,460,701 (GRCm39) |
V2654G |
probably benign |
Het |
| Vinac1 |
A |
G |
2: 128,881,521 (GRCm39) |
L135P |
probably damaging |
Het |
| Zfp335 |
T |
C |
2: 164,734,109 (GRCm39) |
D1330G |
probably damaging |
Het |
|
| Other mutations in Vmn2r25 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00087:Vmn2r25
|
APN |
6 |
123,830,130 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL01781:Vmn2r25
|
APN |
6 |
123,816,324 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL01843:Vmn2r25
|
APN |
6 |
123,829,962 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
IGL02023:Vmn2r25
|
APN |
6 |
123,816,388 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02502:Vmn2r25
|
APN |
6 |
123,816,392 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02709:Vmn2r25
|
APN |
6 |
123,816,723 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL03053:Vmn2r25
|
APN |
6 |
123,800,077 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4468001:Vmn2r25
|
UTSW |
6 |
123,816,557 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4812001:Vmn2r25
|
UTSW |
6 |
123,800,447 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0054:Vmn2r25
|
UTSW |
6 |
123,829,984 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0312:Vmn2r25
|
UTSW |
6 |
123,805,539 (GRCm39) |
splice site |
probably benign |
|
|
R0366:Vmn2r25
|
UTSW |
6 |
123,800,581 (GRCm39) |
nonsense |
probably null |
|
|
R0390:Vmn2r25
|
UTSW |
6 |
123,800,140 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0466:Vmn2r25
|
UTSW |
6 |
123,829,008 (GRCm39) |
missense |
probably benign |
0.16 |
|
R0541:Vmn2r25
|
UTSW |
6 |
123,816,786 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0612:Vmn2r25
|
UTSW |
6 |
123,816,481 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0865:Vmn2r25
|
UTSW |
6 |
123,829,976 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1219:Vmn2r25
|
UTSW |
6 |
123,816,282 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1240:Vmn2r25
|
UTSW |
6 |
123,828,864 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1701:Vmn2r25
|
UTSW |
6 |
123,828,754 (GRCm39) |
splice site |
probably null |
|
|
R1780:Vmn2r25
|
UTSW |
6 |
123,805,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1809:Vmn2r25
|
UTSW |
6 |
123,802,337 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1833:Vmn2r25
|
UTSW |
6 |
123,816,643 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1964:Vmn2r25
|
UTSW |
6 |
123,800,254 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2154:Vmn2r25
|
UTSW |
6 |
123,816,805 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2164:Vmn2r25
|
UTSW |
6 |
123,816,518 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R3799:Vmn2r25
|
UTSW |
6 |
123,830,143 (GRCm39) |
missense |
probably benign |
0.12 |
|
R3836:Vmn2r25
|
UTSW |
6 |
123,830,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4282:Vmn2r25
|
UTSW |
6 |
123,800,606 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4367:Vmn2r25
|
UTSW |
6 |
123,805,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4438:Vmn2r25
|
UTSW |
6 |
123,816,756 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4488:Vmn2r25
|
UTSW |
6 |
123,799,819 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4580:Vmn2r25
|
UTSW |
6 |
123,799,982 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4631:Vmn2r25
|
UTSW |
6 |
123,829,962 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4765:Vmn2r25
|
UTSW |
6 |
123,800,182 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4908:Vmn2r25
|
UTSW |
6 |
123,805,406 (GRCm39) |
missense |
probably benign |
|
|
R5207:Vmn2r25
|
UTSW |
6 |
123,817,062 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5254:Vmn2r25
|
UTSW |
6 |
123,802,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5444:Vmn2r25
|
UTSW |
6 |
123,805,451 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5586:Vmn2r25
|
UTSW |
6 |
123,802,255 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5607:Vmn2r25
|
UTSW |
6 |
123,805,318 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R5985:Vmn2r25
|
UTSW |
6 |
123,800,587 (GRCm39) |
missense |
probably benign |
|
|
R6046:Vmn2r25
|
UTSW |
6 |
123,799,876 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6057:Vmn2r25
|
UTSW |
6 |
123,799,900 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6569:Vmn2r25
|
UTSW |
6 |
123,828,941 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6826:Vmn2r25
|
UTSW |
6 |
123,800,071 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7054:Vmn2r25
|
UTSW |
6 |
123,800,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7120:Vmn2r25
|
UTSW |
6 |
123,805,394 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R7177:Vmn2r25
|
UTSW |
6 |
123,816,882 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7287:Vmn2r25
|
UTSW |
6 |
123,829,040 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7397:Vmn2r25
|
UTSW |
6 |
123,800,498 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7486:Vmn2r25
|
UTSW |
6 |
123,800,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7699:Vmn2r25
|
UTSW |
6 |
123,816,882 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7700:Vmn2r25
|
UTSW |
6 |
123,816,882 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7759:Vmn2r25
|
UTSW |
6 |
123,800,339 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7802:Vmn2r25
|
UTSW |
6 |
123,828,791 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7850:Vmn2r25
|
UTSW |
6 |
123,805,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8064:Vmn2r25
|
UTSW |
6 |
123,800,581 (GRCm39) |
nonsense |
probably null |
|
|
R8170:Vmn2r25
|
UTSW |
6 |
123,829,976 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8340:Vmn2r25
|
UTSW |
6 |
123,829,972 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8346:Vmn2r25
|
UTSW |
6 |
123,802,350 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8395:Vmn2r25
|
UTSW |
6 |
123,799,982 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8889:Vmn2r25
|
UTSW |
6 |
123,800,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9094:Vmn2r25
|
UTSW |
6 |
123,805,391 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9204:Vmn2r25
|
UTSW |
6 |
123,830,092 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9253:Vmn2r25
|
UTSW |
6 |
123,816,960 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9392:Vmn2r25
|
UTSW |
6 |
123,816,937 (GRCm39) |
missense |
probably benign |
|
|
R9520:Vmn2r25
|
UTSW |
6 |
123,830,066 (GRCm39) |
nonsense |
probably null |
|
|
R9525:Vmn2r25
|
UTSW |
6 |
123,800,164 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9622:Vmn2r25
|
UTSW |
6 |
123,816,579 (GRCm39) |
missense |
probably damaging |
0.99 |
|
X0020:Vmn2r25
|
UTSW |
6 |
123,816,359 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
Z1176:Vmn2r25
|
UTSW |
6 |
123,799,856 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCCCTAAGATAGAGTTCTCCCC -3'
(R):5'- AGGAAATAGATACTCTCTGACTGTG -3'
Sequencing Primer
(F):5'- AGATAGAGTTCTCCCCTCATATCATC -3'
(R):5'- ACTCTCTGACTGTGTTTTGTATGTTC -3'
|
| Posted On |
2015-04-17 |
Incidental Mutation