Incidental Mutation 'R3951:Olfr1128'
ID307920
Institutional Source Beutler Lab
Gene Symbol Olfr1128
Ensembl Gene ENSMUSG00000075156
Gene Nameolfactory receptor 1128
SynonymsGA_x6K02T2Q125-49048592-49047657, MOR176-3
MMRRC Submission 040828-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.067) question?
Stock #R3951 (G1)
Quality Score225
Status Validated
Chromosome2
Chromosomal Location87544607-87545542 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 87545065 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 160 (T160A)
Ref Sequence ENSEMBL: ENSMUSP00000099684 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102624]
Predicted Effect probably damaging
Transcript: ENSMUST00000102624
AA Change: T160A

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000099684
Gene: ENSMUSG00000075156
AA Change: T160A

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 5.3e-46 PFAM
Pfam:7tm_1 41 290 3.2e-16 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000120590
Meta Mutation Damage Score 0.0248 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.9%
Validation Efficiency 100% (55/55)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017N19Rik T C 10: 100,615,296 probably benign Het
4932414N04Rik T C 2: 68,664,403 probably null Het
Akr1c18 C T 13: 4,135,285 V283I probably benign Het
Atp2b2 T A 6: 113,760,831 M861L possibly damaging Het
Cdh23 T C 10: 60,657,326 Y3C probably benign Het
Clspn A G 4: 126,576,379 E814G probably damaging Het
Csgalnact1 T C 8: 68,461,262 Q97R probably benign Het
Dera A G 6: 137,837,120 Y100C probably damaging Het
Ect2 A T 3: 27,130,120 D517E probably benign Het
Epha4 A T 1: 77,399,716 Y509N probably damaging Het
Fat2 T C 11: 55,296,382 T1213A probably benign Het
Fkbp8 T A 8: 70,532,661 L275Q probably damaging Het
Gabrb2 A G 11: 42,626,881 Y510C probably damaging Het
Gda T C 19: 21,472,445 T16A probably benign Het
Ggcx G A 6: 72,426,558 G363R probably benign Het
Gm527 T G 12: 64,923,502 probably benign Het
Hoxb2 A G 11: 96,353,175 E204G probably damaging Het
Hsd17b11 G A 5: 103,992,937 probably benign Het
Kat14 T C 2: 144,407,329 probably benign Het
Kif16b C T 2: 142,707,359 V1079I probably benign Het
Klhl29 T A 12: 5,140,660 S112C probably damaging Het
Lpcat2 G T 8: 92,864,903 M58I probably benign Het
Lrrc8d G T 5: 105,814,276 V851F probably benign Het
Ltbp3 T C 19: 5,756,001 V929A probably damaging Het
Map3k20 T G 2: 72,438,300 I550M probably damaging Het
Map3k9 T C 12: 81,722,521 M941V probably benign Het
Myom2 A T 8: 15,084,556 Y453F probably benign Het
Ncapd2 T C 6: 125,186,784 K78E probably damaging Het
Ncor2 G T 5: 125,032,256 D1496E possibly damaging Het
Ndnf T C 6: 65,703,141 Y135H possibly damaging Het
Ndst1 T C 18: 60,697,139 N633S probably benign Het
Nmur2 G C 11: 56,040,225 P220R probably damaging Het
Nsd1 G C 13: 55,268,454 E1438Q probably benign Het
Olfr1043 G T 2: 86,162,618 C110* probably null Het
Olfr1413 T A 1: 92,573,789 M206K possibly damaging Het
Olfr229 A T 9: 39,910,725 R307S probably benign Het
Pom121l2 T G 13: 21,982,128 S190A probably damaging Het
Prpmp5 G A 6: 132,312,694 P56S unknown Het
Rtn4ip1 T A 10: 43,909,897 probably null Het
Scarb1 A C 5: 125,287,411 C85G probably damaging Het
Sh2d4b A G 14: 40,872,546 I159T probably damaging Het
Sntg1 C T 1: 8,782,901 probably benign Het
Sos1 G A 17: 80,424,181 T630I probably damaging Het
Spata7 T A 12: 98,669,473 D517E probably damaging Het
Tcaf1 T C 6: 42,679,059 T328A probably benign Het
Ticrr T C 7: 79,682,069 L776S probably damaging Het
Trpc2 T A 7: 102,093,574 M597K probably damaging Het
Ttc37 T G 13: 76,130,219 L551V probably damaging Het
Tubb3 C A 8: 123,421,264 T312N probably damaging Het
Ubr4 G A 4: 139,393,094 V277M probably damaging Het
Uhrf2 G A 19: 30,079,861 R473Q probably damaging Het
Vmn2r43 T A 7: 8,255,320 H298L probably benign Het
Other mutations in Olfr1128
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02122:Olfr1128 APN 2 87545103 missense probably benign 0.00
IGL02638:Olfr1128 APN 2 87544749 missense probably damaging 1.00
IGL02749:Olfr1128 APN 2 87544657 missense probably damaging 1.00
R1650:Olfr1128 UTSW 2 87545428 missense probably benign 0.01
R1789:Olfr1128 UTSW 2 87544983 missense probably damaging 1.00
R2100:Olfr1128 UTSW 2 87544825 missense probably damaging 1.00
R2163:Olfr1128 UTSW 2 87544894 missense probably damaging 1.00
R3950:Olfr1128 UTSW 2 87545065 missense probably damaging 1.00
R3952:Olfr1128 UTSW 2 87545065 missense probably damaging 1.00
R6185:Olfr1128 UTSW 2 87544743 missense possibly damaging 0.87
Predicted Primers PCR Primer
(F):5'- CAGATGGTCGCAATGATGTAGC -3'
(R):5'- GGATTCCTTGCAATTTATGTGCTC -3'

Sequencing Primer
(F):5'- TGGTCGCAATGATGTAGCAGTAG -3'
(R):5'- CTTGCAATTTATGTGCTCTTCAGATG -3'
Posted On2015-04-17