Incidental Mutation 'R3930:Trim43a'
ID 308425
Institutional Source Beutler Lab
Gene Symbol Trim43a
Ensembl Gene ENSMUSG00000090693
Gene Name tripartite motif-containing 43A
Synonyms Gm6021
MMRRC Submission 040917-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.137) question?
Stock # R3930 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 88462944-88470872 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 88465131 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 153 (I153F)
Ref Sequence ENSEMBL: ENSMUSP00000127527 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000164661] [ENSMUST00000215498] [ENSMUST00000216686]
AlphaFold Q3TL54
Predicted Effect probably benign
Transcript: ENSMUST00000164661
AA Change: I153F

PolyPhen 2 Score 0.040 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000127527
Gene: ENSMUSG00000090693
AA Change: I153F

DomainStartEndE-ValueType
RING 16 56 9.6e-7 SMART
Blast:BBOX 88 129 1e-7 BLAST
PDB:2VOK|B 328 445 5e-14 PDB
Blast:SPRY 335 441 1e-19 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000215498
Predicted Effect probably benign
Transcript: ENSMUST00000216686
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.2%
Validation Efficiency 100% (58/58)
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4fm4 C T 4: 144,396,698 (GRCm39) E345K probably damaging Het
Bpifb1 A G 2: 154,057,242 (GRCm39) N400S possibly damaging Het
Cep250 G A 2: 155,834,552 (GRCm39) R2159K probably damaging Het
Crhr1 T A 11: 104,044,377 (GRCm39) S22T probably benign Het
Cyp4a10 G T 4: 115,381,980 (GRCm39) V221L probably benign Het
D1Pas1 G T 1: 186,700,477 (GRCm39) W135C probably damaging Het
Dcbld2 T C 16: 58,285,701 (GRCm39) L620P probably damaging Het
Dnah17 C T 11: 117,971,675 (GRCm39) probably benign Het
Dnm3 T C 1: 161,911,699 (GRCm39) D66G probably damaging Het
Fzd10 G A 5: 128,679,476 (GRCm39) V399M probably damaging Het
Gm10801 T A 2: 98,494,361 (GRCm39) I146N possibly damaging Het
Gm525 T A 11: 88,965,830 (GRCm39) probably null Het
Gpr37l1 T C 1: 135,089,100 (GRCm39) I322V probably benign Het
Grid2ip T G 5: 143,371,794 (GRCm39) S679R probably damaging Het
Gyg1 A T 3: 20,209,189 (GRCm39) S15T probably benign Het
Hace1 G A 10: 45,587,604 (GRCm39) C901Y probably benign Het
Hjurp GT GTT 1: 88,194,246 (GRCm39) probably null Het
Hp1bp3 C T 4: 137,949,018 (GRCm39) A27V probably benign Het
Hsf5 A G 11: 87,522,508 (GRCm39) Y367C probably damaging Het
Igf2r T C 17: 12,924,716 (GRCm39) I1034V probably benign Het
Itpr1 A G 6: 108,371,802 (GRCm39) T1159A probably benign Het
Kirrel1 C T 3: 86,996,458 (GRCm39) M380I probably null Het
Lrrc14 T C 15: 76,597,765 (GRCm39) V165A probably benign Het
Lrrc45 C T 11: 120,609,503 (GRCm39) A422V probably benign Het
Lrrk2 T A 15: 91,651,664 (GRCm39) probably null Het
Map3k4 T C 17: 12,454,880 (GRCm39) H1370R possibly damaging Het
Mpo A G 11: 87,691,866 (GRCm39) Y433C probably damaging Het
Nfkbil1 G T 17: 35,439,932 (GRCm39) Q194K probably benign Het
Nin C T 12: 70,125,016 (GRCm39) G102E probably damaging Het
Nmt1 T C 11: 102,943,059 (GRCm39) V138A probably benign Het
Optc T A 1: 133,828,920 (GRCm39) R176* probably null Het
Or10aa3 A T 1: 173,878,076 (GRCm39) I46F probably damaging Het
Or4c110 A G 2: 88,832,377 (GRCm39) F85S probably benign Het
Or52ae9 A C 7: 103,389,794 (GRCm39) Y218D probably damaging Het
Or6n2 T A 1: 173,897,147 (GRCm39) F94L probably damaging Het
Oxct1 T A 15: 4,066,601 (GRCm39) N72K possibly damaging Het
Plxna2 G A 1: 194,477,218 (GRCm39) A1243T probably benign Het
Rin1 G T 19: 5,103,002 (GRCm39) L430F probably benign Het
Ros1 A T 10: 52,070,944 (GRCm39) S37T possibly damaging Het
Rrp36 G T 17: 46,983,732 (GRCm39) Q27K probably damaging Het
Sez6 T C 11: 77,867,708 (GRCm39) I875T probably damaging Het
Sfrp5 T G 19: 42,190,257 (GRCm39) Y65S probably damaging Het
Slc25a54 T A 3: 109,023,820 (GRCm39) L472I probably benign Het
Slc35d3 T C 10: 19,724,605 (GRCm39) E417G probably damaging Het
Sumf2 A G 5: 129,878,820 (GRCm39) D52G probably benign Het
Sympk A G 7: 18,781,447 (GRCm39) N801S possibly damaging Het
Taf7l2 G T 10: 115,948,540 (GRCm39) Q329K possibly damaging Het
Tcstv2c G A 13: 120,616,368 (GRCm39) C69Y probably damaging Het
Tmem38b T C 4: 53,854,398 (GRCm39) F210S probably damaging Het
Tnks T A 8: 35,407,966 (GRCm39) H254L probably damaging Het
Trappc10 A T 10: 78,046,237 (GRCm39) V451E probably benign Het
Tulp1 T C 17: 28,572,683 (GRCm39) N213S probably damaging Het
Ubr1 T C 2: 120,746,951 (GRCm39) D830G probably benign Het
Uqcc3 C T 19: 8,858,069 (GRCm39) probably null Het
Vmn2r26 T A 6: 124,002,938 (GRCm39) M116K probably benign Het
Zscan12 A G 13: 21,552,800 (GRCm39) Q208R probably benign Het
Other mutations in Trim43a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02400:Trim43a APN 9 88,464,165 (GRCm39) missense probably benign 0.00
IGL02864:Trim43a APN 9 88,470,165 (GRCm39) missense probably benign 0.20
R0114:Trim43a UTSW 9 88,466,213 (GRCm39) missense probably damaging 1.00
R0436:Trim43a UTSW 9 88,470,240 (GRCm39) missense probably damaging 1.00
R0514:Trim43a UTSW 9 88,466,389 (GRCm39) nonsense probably null
R0682:Trim43a UTSW 9 88,464,199 (GRCm39) missense probably benign 0.08
R0709:Trim43a UTSW 9 88,464,199 (GRCm39) missense probably benign 0.08
R0727:Trim43a UTSW 9 88,464,199 (GRCm39) missense probably benign 0.08
R1237:Trim43a UTSW 9 88,465,042 (GRCm39) intron probably benign
R1239:Trim43a UTSW 9 88,465,042 (GRCm39) intron probably benign
R1445:Trim43a UTSW 9 88,465,042 (GRCm39) intron probably benign
R1448:Trim43a UTSW 9 88,464,146 (GRCm39) missense probably damaging 1.00
R1584:Trim43a UTSW 9 88,470,211 (GRCm39) missense probably damaging 1.00
R1925:Trim43a UTSW 9 88,464,371 (GRCm39) missense probably benign 0.08
R1992:Trim43a UTSW 9 88,466,312 (GRCm39) missense probably damaging 1.00
R2074:Trim43a UTSW 9 88,468,147 (GRCm39) missense possibly damaging 0.91
R3927:Trim43a UTSW 9 88,465,042 (GRCm39) intron probably benign
R4418:Trim43a UTSW 9 88,464,206 (GRCm39) missense probably damaging 1.00
R5488:Trim43a UTSW 9 88,464,229 (GRCm39) missense probably damaging 0.97
R5489:Trim43a UTSW 9 88,464,229 (GRCm39) missense probably damaging 0.97
R6498:Trim43a UTSW 9 88,464,395 (GRCm39) missense probably damaging 1.00
R6742:Trim43a UTSW 9 88,470,399 (GRCm39) missense possibly damaging 0.92
R7535:Trim43a UTSW 9 88,470,201 (GRCm39) missense probably damaging 0.99
R7539:Trim43a UTSW 9 88,465,096 (GRCm39) missense probably benign 0.08
R7580:Trim43a UTSW 9 88,465,042 (GRCm39) intron probably benign
R7943:Trim43a UTSW 9 88,464,238 (GRCm39) missense probably benign 0.16
R8073:Trim43a UTSW 9 88,464,490 (GRCm39) missense possibly damaging 0.71
R8983:Trim43a UTSW 9 88,464,404 (GRCm39) missense probably benign 0.23
R9030:Trim43a UTSW 9 88,465,042 (GRCm39) intron probably benign
R9646:Trim43a UTSW 9 88,466,392 (GRCm39) missense probably benign 0.08
Predicted Primers PCR Primer
(F):5'- AGCCCAGGGTGGTTGTATTC -3'
(R):5'- TGCTGTTTCACTAACATGCCTG -3'

Sequencing Primer
(F):5'- CCCAGGGTGGTTGTATTCTGTAATTC -3'
(R):5'- TCACTAACATGCCTGCAGTG -3'
Posted On 2015-04-17